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Anti-proliferative
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Peroxisome proliferator-activated receptor gamma (PPARG) is a member of the nuclear receptor family. It is involved in the regulation of adipogenesis, lipid metabolism, insulin sensitivity, vascular homeostasis and inflammation.
12p
vikoch
27-06-2024
1
1
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Several novel of polymethoxyquercetin Mannich base derivatives (2-7) were synthesized through O-methylation and based on Mannich reaction with various secondary amines and formaldehyde, starting from abundant and inexpensive natural sources quercetin.
8p
vimarillynhewson
02-01-2024
1
1
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Ebook "Sesquiterpene lactones: Advances in their chemistry and biological aspects" addresses chemical and biological aspects related to sesquiterpene lactones (STLs). Experts in different fields have been invited to contribute on this class of compound's chemistry, isolation and identification, biological activities (antibacterial, antifungal, antiviral, antitrypanosomal, antileishmanial,antiplasmodial, antiproliferative and antiinflammatory), synthesis, biosynthesis, derivatization and QSAR analysis.
379p
lamquandat
28-12-2023
7
2
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Breast cancer is the most common malignancy globally, and is considered a major cause of cancer-related death. Tremendous effort is exerted to identify an optimal anticancer drug with limited side effects. The quinoline derivative RIMHS-Qi-23 had a wide-spectrum antiproliferative activity against various types of cancer cells.
12p
vialfrednobel
23-12-2023
3
3
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In this study, the synthesis of dimeric disulfide-Schiff bases was carried out using two methods. The structures of the obtained Schiff bases were elucidated by various spectroscopic methods as well as elemental analysis. The Schiff base derivative compounds (3a-6) were screened for in vitro antibacterial activity against multidrug-resistant microorganisms using microdilution method. All the tested compounds showed varying inhibition zones against the pathogens.
22p
lyhuyenthu
31-01-2023
9
2
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The 2-methylpyridine, 2-diethylaminoethyl, and isopentyl linked a series of symmetric and unsymmetric benzimidazolium salts 2a-e were prepared and used in the synthesis of silver-N-heterocyclic carbene (NHC) complexes (3a-e). We examined the effect of the structural difference of complexes on anticancer activity via different arenes and metal centers. Antiproliferative activity of 5a-h and 3a was tested against human cervix adenocarcinoma (HeLa) and rat glioblastoma (C6) cell lines by ELISA assay.
26p
lyhuyenthu
31-01-2023
4
2
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Royal jelly (RJ) is reflecting the flora around the apiaries as a result of the foraging activity of honeybees and therefore, pollen analysis could be used to verify its botanical/geographical origin. Colon cancer treatment by means of chemotherapeutics agents reflects a substantial problem for the organism due to high toxicity to other viable cells of the body. To explore a chemopreventive approach to enhancing colon cancer treatment efficacy, the antioxidant and antiproliferative effects of RJ in HT-29 colon cancer cells were assessed.
11p
lyhuyenthu
31-01-2023
7
1
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The 2-benzoylbenzoxazole derivatives were known for their significant biological activities such as antiproliferative activity, inhibition of FAAH enzyme (fatty acid amide hydrolase). In this study, we report a simple and efficient method for the synthesis of such compounds by the direct reaction of o-aminophenol with acetophenone catalyzed by sulfur in DMSO.
8p
vimclaren
12-10-2022
7
2
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Since colon cancer stem cells (CSCs) play an important role in chemoresistance and in tumor recurrence and metastasis, targeting of CSCs has emerged as a sophisticated strategy for cancer therapy. α-mangostin (αM) has been confirmed to have antiproliferative and apoptotic effects on cancer cells.
12p
viangelamerkel
27-07-2022
2
2
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The antiproliferative and cytotoxic activities of C1 and C2 were significantly lower than those of free anions, indicating that the extreme cytotoxicity of free anions decreased to safe levels in C1 and C2. In conclusion, the results show that these novel compounds possess anticancer activities. The use of metals in medicine dates back to antiquity, with various complexes being used to treat different ailments. Even today, metal complexes and their application in medicine have been studied extensively.
18p
langthannam
29-12-2021
7
0
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Novel 1-substituted 3-(p-isopropylphenyl)-5-phenylformazans (3a–g) were synthesized and characterized by elemental analysis, 1H NMR, and FT-IR techniques and UV-visible spectroscopy. Antiproliferative activities of 3a–g against HeLa and C6 cells were determined using the BrdU cell proliferation ELISA assay. 5-Florouracil was used as the positive control. The effects of substituents (–H, –CH3, and –I) and their positions (ortho, meta, and para) on the antiproliferative activities were evaluated.
9p
tudichquannguyet
29-11-2021
8
1
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In this research, a new series of (E) -3-(4-substitutedphenyl)-1-(4’-morpholinophenyl)prop-2-en-1-one derivatives 1–7 was synthesized, aiming to develop effective antiproliferative agents. The antiproliferative activities of compounds 1–7 were examined against HeLa and C6 cell lines at eight different concentrations using the BrdU ELISA assay. The activity results were compared with reference anticancer drug 5-fluorouracil (5-FU). Compound 1 had almost the same antiproliferative activity as 5-FU.
19p
tudichquannguyet
29-11-2021
6
0
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New azo dyes bearing 2-pyridone and benzimidazole moieties were prepared using diazotization of 4-(1Hbenzo[d]imidazol-2-yl)aniline and coupling of the obtained diazonium salt with substituted 3-cyano-2-pyridones. Obtained compounds were characterized via UV-Vis, FT-IR, and 1H and 13C NMR spectroscopy as well as by elemental analysis data. The UV-Vis spectra of the synthesized dyes were measured in thirteen solvents of different properties at room temperature. Solvatochromism and tautomerism of novel azo dyes were discussed.
12p
tudichquannguyet
29-11-2021
11
0
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protect endangered tissueBenzoxazoles are DNA base bioisosteres and studies suggest that their derivatives have antiproliferative activities. Based on their antiproliferative activities they have been mostly studied as new generation anticancer drugs. In our study we exploited their antiproliferative effect, aiming to delineate bisbenzoxazole derivatives’ (RHE 231 and RHE 238) potential antiinflammatory effect on mouse macrophages that are activated in vitro through danger signal LPS stimulation. RAW 267.
15p
tudichquannguyet
29-11-2021
10
1
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The experiment was conducted in order to investigate the antitumor, antiproliferative and antiangiogenic activity of citrus bioflavonoid, the hesperidin (HES), on N-methlyN-nitrosourea (MNU) induced mammary tumors in Sprague-Dawley (SD) rats with reference to histopathology and immunohistochemical expressions of PCNA, Ki-67 and VEGF markers.
12p
chauchaungayxua12
29-07-2021
18
1
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Objectives of the dissertation: Structured design of coxib - combretastatin hybrid compounds. Synthesize coxib - combretastatin hybrid compounds. Screening for anti-cancer and anti-inflammatory activities of hybrid compounds. Identifying anti-inflammatory and anti-cancer mechanisms of hybrid compounds. Docking of a hybrid coxib - combretastatin compound with two purpose effect COX2 and tubulin.
27p
extraenglish
24-05-2021
8
3
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Objectives of the dissertation: Structured design of coxib - combretastatin hybrid compounds; synthesize coxib - combretastatin hybrid compounds; screening for anti-cancer and anti-inflammatory activities of hybrid compounds; icreening for anti-cancer and anti-inflammatory activities of hybrid compounds.
27p
capheviahe27
23-02-2021
13
3
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Somatostatin analogues (SSAs) are indicated to relieve carcinoid syndrome but seem to have antiproliferative effects on neuroendocrine tumours (NETs). This is the first prospective study investigating tumour stabilisation with the long-acting SSA lanreotide Autogel in patients with progressive NETs.
9p
vijennie2711
29-09-2020
16
2
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Prognosis of adult patients suffering from acute lymphoblastic leukemia (ALL) is still unsatisfactory. Targeted therapy via inhibition of deregulated signaling pathways appears to be a promising therapeutic option for the treatment of ALL.
9p
virose2711
25-09-2020
10
0
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Cancer stem cells (CSCs) are considered the cell subpopulation responsible for breast cancer (BC) initiation, growth, and relapse. CSCs are identified as self-renewing and tumor-initiating cells, conferring resistance to chemo- and radio-therapy to several neoplasias. Nowadays, th (about 10mM)e pharmacological targeting of CSCs is considered an ineludible therapeutic goal.
17p
vialabama2711
21-09-2020
11
0
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