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Antimalarial activity
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Pyrimidine derivatives are well known due to their remarkable pharmacological potential in various fields of science, and they are also present in some natural substances like DNA and RNA. These scaffolds manifest diversified biological activities such as antimicrobial, antiinflammatory, anti-HIV, antitubercular, antitumor, antineoplastic, and antimalarial. A pyrimidine ring is constructed when chalcones, amidines, guanidine, nitriles, isocyanates, urea, thiourea, and aminopyrazoles undergo condensation, coupling, or cyclization reactions.
38p
tudichquannguyet
29-11-2021
11
1
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The aim of this research is determining the chemical compound of lichen Usnea sp extract and its potential as anti malariai medication. Extracts are obtained by fractional extraction with maceration method using organic solvent. Phytochemical test with chemical reagent and antimalarial potential test through observation of ant plasmodium activity strains of plasmodium falciparum (FCR-3) measured on IC50.
8p
caygaocaolon8
07-11-2020
5
1
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Evaluate the anti-tumor activity of ozonide antimalarials using a chemoresistant neuroblastoma cell line, BE (2)-c. Methods: The activity of 12 ozonides, artemisinin, and two semisynthetic artemisinins were tested for activity against two neuroblastoma cell-lines (BE (2)-c and IMR-32) and the Ewing’s Sarcoma cell line A673 in an MTT viability assay.
10p
vimale2711
25-08-2020
12
2
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The increased multidrug resistance among antimalarial drugs produces the urgency of potent anti malarial to combat resistant malaria and the malaria burden worldwide. The protein which may prevent the growth or transmission of malaria parasite may be the great target for rational drug designing.
13p
vijiraiya2711
27-05-2020
7
1
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Heterocyclic compounds are inevitable in a numerous part of life sciences. These molecules perform various noteworthy functions in nature, medication and innovation.
21p
vijiraiya2711
27-05-2020
10
1
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Dihydrofolate reductase (DHFR) is an important enzyme for de novo synthesis of nucleotides in Plasmodium falciparum and it is essential for cell proliferation. DHFR is a well known antimalarial target for drugs like cycloguanil and pyrimethamine which target its inhibition for their pharmacological actions.
11p
vijiraiya2711
27-05-2020
32
1
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Replacement of chloride ions in cyanuric chloride give several variants of 1,3,5-triazine derivatives which were investigated as biologically active small molecules. These compounds exhibit antimalarial, antimicrobial, anti-cancer and anti-viral activities, among other beneficial properties.
12p
vijiraiya2711
27-05-2020
14
1
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The antimalarial activity of plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), a naturally occurring naphthoquinone widely distributed in the Plumbaginaceae family has previously been demonstrated in vitro (good activity) and in vivo (weak activity).
10p
vienzym2711
30-03-2020
12
0
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Schiff bases are aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of biological activities. This short review compiles examples of the most promising antimalarial, antibacterial, antifungal, and antiviral Schiff bases. An overview of synthetic methodologies used for the preparation of Schiff bases is also described.
8p
kethamoi1
20-11-2019
10
0
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Different crude methanolic and chloroform extracts of Withania somnifera leaves, and column fractions of the methanolic extract, were tested in vivo for antimalarial activity on Swiss albino male mice.
4p
vivant2711
01-02-2019
20
1
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The lupane triterpenoid lupeol is found in a variety of plants. Its biological activities have attracted a great deal of interests. A number of studies on the antiinflammatory, antimycobacterial, antimalarial and anticancer activities of this compound and its derivatives have been reported. Based on our knowledge, there have not been any reports on the antimicrobial activity of lupeol and its derivatives.
5p
uocvong04
24-09-2015
58
2
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Gossypol, a yellow pigment, isolated from cotton seeds, exhibits many interesting biological activities: antitumor, antimalarial, anti-HIV [1]. But gossypol is toxic and this toxicity may be related to the two-functional aldehyde groups [2]. Many authors prepared the Schiff’s’ base adducts of gossypol from 1985 to 2002, but these authors did not pay attention to the factor that these adducts may present under or the imine form or the enamine one.
5p
uocvong04
24-09-2015
36
4
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Plasmodium falciparum malaria remains a serious endemic disease in many parts of the world. It is estimated that 120 million cases occur worldwide each year, causing over one million deaths. The problem has been compounded by the emergence of strains of P. falciparum resistant to virtually all antimalarial agents. Resistance to chloroquine has now spread to almost all areas where malaria is endemic. Chloroquine-resistant strains are typically cross resistant to all drugs of relative chemical structure, and therefore the need for finding new molecules with novel modes of action is urgent.
4p
uocvong04
24-09-2015
34
4
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Thioredoxins are a group of small redox-active proteins involved in cellular redox regulatory processes as well as antioxidant defense. Thioredoxin, glutaredoxin, and try-paredoxin are members of the thioredoxin superfamily and share structural and functional characteristics. In the mal-arial parasite, Plasmodium falciparum, a functional thio-redoxin and glutathione system have been demonstrated and are considered to be attractive targets for antimalarial drug development.
8p
tumor12
20-04-2013
40
2
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Malaria remains a major health problem especially in trop-ical and subtropical regions of the world, and therefore developing new antimalarial drugs constitutes an urgent challenge. Lipid metabolism has been attracting a lot of attention as an application for malarial chemotherapeutic purposes in recent years. However, little is known about glycosphingolipid biosynthesis inPlasmodium falciparum. In this report we describe for the first time the presence of an active glucosylceramide synthase in the intraerythrocytic stages of the parasite....
11p
dell39
03-04-2013
28
3
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Most drugs against malaria that are available or under development target a single process of the parasite infective cycle, favouring the appearance of resistant mutants which are easily spread in areas under chemotherapeutic treatments.
11p
cosis54
04-01-2013
30
3
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