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Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine

Chia sẻ: ViJiraiya2711 ViJiraiya2711 | Ngày: | Loại File: PDF | Số trang:11

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Dihydrofolate reductase (DHFR) is an important enzyme for de novo synthesis of nucleotides in Plasmodium falciparum and it is essential for cell proliferation. DHFR is a well known antimalarial target for drugs like cycloguanil and pyrimethamine which target its inhibition for their pharmacological actions.

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Nội dung Text: Design, synthesis and biological evaluation of antimalarial activity of new derivatives of 2,4,6-s-triazine

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