Antimicrobial agents

This study aimed to quantify the phenolic contents and the antioxidant capacities of leaf extract powders from three Myrtaceae plants, namely Cleistocalyx operculatus (Vietnamese name: Vối), Psidium guajava (Ổi), and Rhodomyrtus tomentosa (Sim), investigate their inhibitive activities on the growth of bacteria isolated from spoiled shrimps, and evaluate their values as preservative agents in the cold storage of Pacific whiteleg shrimps (Penaeus vannamei).

15p vibecca 01-10-2024 3 2   Download

In this study, we assessed the status of antibiotic resistance of H. pylori isolates to antimicrobial agents at Hospital of Hue University of Medicine and Pharmacy in Central Vietnam and identified the underlying molecular mechanisms related to tetracycline and amoxicillin resistance.

8p viharuno 03-01-2025 4 2   Download

Trong bài giảng này gồm có một số nội dung như: Selecting a food antimicrobial agent, benzoic acid and Benzoates, dimethyl dicarbonate, propionic acid and propionates,... Mời các bạn cùng tham khảo để nắm bắt các nội dung chi tiết.

60p namthangtinhlang_04 15-11-2015 174 42   Download

This history of antimicrobials is marked with impressive discoveries, the majority of which have their origin in natural products. However in this work, the antimicrobial activity of β- nitrostyrenes and related compounds of synthetic origin is reviewed and investigated with a particular focus on the influence of fluorine functionality. Various fluorinated β-methyl-β-nitrostyrene compounds were prepared, their minimum inhibition concentration in cultures of Gram positive, Gram negative and a fungus and their lipophilicity was determined.

133p runthenight05 01-03-2023 10 3   Download

The structure activity relationship (SAR) study revealed that incorporation of 4-O-lauroyl group in rhamnopyranoside frame work along with 2,3-di-O-acyl group increased the antifungal potentiality of the rhamnopyranosides.

10p tocectocec 25-05-2020 11 2   Download

Antimicrobial resistance is an emerging challenge for health personnel and researchers. In such scenario, alternative strategies targeting novel ways to kill or inhibit growth of microbes are need of the hour. Antimicrobial peptide can be a promising candidate to deal with this crisis. Extracellular matrix protein vitronectin (Vn) is recently being established as a bactericidal agent against certain microbes. Caprine Vn has got few structural alterations as compare to human Vn.

7p nguaconbaynhay5 16-05-2020 16 2   Download

Xanthomonas campestrispv.vitians is a Gram-negative plant-associated bacterium that acts as causative agent of bacterial leaf spot and headrot in lettuce. The lipopolysac-charide of this bacterium is suspected to be an important molecule for adhesion to and infection of the plants. The lipopolysaccharide has been isolated from the phenol phase and the O-specific chain characterized by compositional analysis, high fieldNMRandMALDI-TOFMS.

9p research12 23-04-2013 45 2   Download

Imidazolium trans-imidazoledimethyl sulfoxide-tetrachlo-roruthenate (NAMI-A) is a novel ruthenium-containing experimental antimetastatic agent. Compelling evidence ascribes apivotal role toendothelial cells in theorchestration of tumor angiogenesis and metastatic growth, suggesting antiangiogenic therapy as an attractive approach for anticancer treatment.

10p tumor12 22-04-2013 46 2   Download

A large number of bioactive peptides have been isolated from amphibian skin secretions. These peptides have a variety of actions including antibiotic and anticancer acti-vities and the inhibition of neuronal nitric oxide synthase. We have investigated the structure–activity relationship of citropin 1.1, a broad-spectrum antibiotic and anticancer agent that also causes inhibition of neuronal nitric oxide synthase, by making a number of synthetically modified analogues.

13p tumor12 20-04-2013 37 3   Download

Transmissible spongiform encephalopathies (TSE) are fatal neuro-degenerative diseases of humans and animals. The underlying infectious agent, the prion, accumulates not only in the central ner-vous system (CNS) but also in secondary lymphoid organs. I will revisit the role of the immune system in peripheral prion pathogen-esis, while focusing on the mechanisms by which extraneural and extralymphatic prion infectivity develops.

64p fptmusic 11-04-2013 37 4   Download

The enzymatic nitration of tryptophan derivatives by oxi-dation of nitrite has been studied using lactoperoxidase and horseradish peroxidase, and compared with the chemical nitration produced by nitrogen dioxide and peroxynitrite. HPLC, mass spectra and NMR analysis of the mixture of products clearly show that nitrationoccurs at position 4-, 6-, 7-, andN 1 of the indole ring, and nitrosation at positionN 1 . Kinetic studies performed on peroxidase/NO2 – /H2O2 sys-tems showed substrate saturation behavior with all the tryptophan derivatives employed. ...

12p dell39 03-04-2013 43 4   Download

Type IIa bacteriocins, which are isolated from lactic acid bacteria that are useful for food preservation, are potent antimicrobial peptides with considerable potential as therapeutic agents for gastrointestinal infections in mam-mals. They are ribosomally synthesized as precursors with an N-terminal leader, typically 18–24 amino acid residues in length, which is cleaved during export from the produ-cing cell.

9p dell39 03-04-2013 47 5   Download

Chronic hepatitis C virus (HCV) infection is a clinically important liver disease with limited therapeutic options in a significant proportion of patients. Therefore, novel efficient therapeutic agents are needed. Because the 5¢- and 3¢-untranslated regions (UTRs) of HCV are highly conserved and functionally important for HCV replication, they are attractive targets for RNA-cleaving ribozymes or small interfering RNAs (siRNAs).

13p dell39 27-03-2013 52 5   Download

Cationic antimicrobial peptides are naturally occurring antibiotics that are actively being explored as a new class of anti-infective agents. We recently identified three cathelicidin antimicrobial peptides from chicken, which have potent and broad-spectrum antibacterial activitiesin vitro (Xiao Y, Cai Y, Bommineni YR, Fernando SC, Prakash O, Gilliland SE & Zhang G (2006)J Biol Chem281, 2858–2867).

13p inspiron33 26-03-2013 52 4   Download

Surfactant-like membranes containing the 21-residue peptide KLLLL-KLLLLKLLLLKLLLLK (KL4 ), have been clinically tested as a therapeu-tic agent for respiratory distress syndrome in premature infants. The aims of this study were to investigate the interactions between the KL4 peptide and lipid bilayers, and the role of both the lipid composition and KL4 structure on the surface adsorption activity of KL4 -containing membranes.

13p inspiron33 26-03-2013 41 4   Download

Shikimate dehydrogenase (SDH) is the fourth enzyme involved in the shiki-mate pathway. It catalyzes the NADPH-dependent reduction of 3-dehy-droshikimate to shikimate, and has been developed as a promising target for the discovery of antimicrobial agent. In this report, we identified a new aroEgene encoding SDH fromHelicobacter pyloristrain SS1. The recom-binantH.

11p inspiron33 23-03-2013 22 3   Download

We investigated the metabolism ofl-lactate in mitochondria isolated from potato tubers grown and saved after harvest in the absence of any chemical agents. Immunologic analysis by western blot using goat polyclonal anti-lactate dehydrogenase showed the existence of a mitochondrial lactate dehydrogenase, the activity of which could be measured photometrically only in mitochondria solubilized with Triton X-100.

11p galaxyss3 21-03-2013 48 3   Download

Transmissible spongiform encephalopathies are fatal neurodegenerative dis-eases that are caused by unconventional pathogens and affect the central nervous system of animals and humans. Several different forms of these dis-eases result from natural infection (i.e. exposure to transmissible spongiform encephalopathy agents or prions, present in the natural environment of the respective host).

18p galaxyss3 21-03-2013 41 3   Download

Human serum paraoxonase 1 (HuPON1; EC 3.1.8.1) is a calcium-depend-ent six-foldb-propeller enzyme that has been shown to hydrolyze an array of substrates, including organophosphorus (OP) chemical warfare nerve agents. Although recent efforts utilizing site-directed mutagenesis have demonstrated specific residues (such as Phe222 and His115) to be import-

9p galaxyss3 21-03-2013 33 4   Download

Vinblastine and paclitaxel (Taxol) are widely used chemotherapeutic drugs that inhibit the normal function of microtubules causing mitotic arrest and cell death. Despite these similarities, the signaling pathways that mediate and regulate cell death induced by these agents remain incompletely under-stood.

11p media19 06-03-2013 51 2   Download