Auto-immune

Patients with rheumatologic preexisting autoimmune disease (PAD) have not been enrolled in clinical trials of immune checkpoint inhibitors (ICIs). Therefore, the risks and benefits of ICI therapy in such patients are unclear. Herein, we investigated the safety and efficacy of ICIs in rheumatologic PAD patients through a meta-analysis.

14p vishanshan 27-06-2024 3 1   Download

Cerebellar degeneration-related (CDR) proteins are associated with paraneoplastic cerebellar degeneration (PCD) – a rare, neurodegenerative disease caused by tumour-induced autoimmunity against neural antigens resulting in degeneration of Purkinje neurons in the cerebellum.

16p vikoch 27-06-2024 1 1   Download

Non-Hodgkin's lymphoma (NHL) is a common hematological malignancy that develops in the lymphatic system. A20, CYLD, IFN-γ, JAK2, PI3KCA, and TP53 are known as inflammationrelated genes in autoimmune diseases and cancers. In the end, 126 patients with NHL and 109 healthy individuals with well-characterized clinical profiles were enrolled.

7p visergeyne 18-06-2024 0 0   Download

In the last decade, remarkable advances have been made in bone marrow transplantation (BMT), which is now becoming a powerful tool in the treatment of diseases such as leukemia, aplastic anemia, and congenital immunodeficiency. In animal experiments, it has been found that BMT can be used to treat not only systemic autoimmune diseases but also organ-specific autoimmune diseases. In humans, it has recently been shown that rheumatoid arthritis, ulcerative colitis, and Crohn's disease can be successfully treated after BMT.

335p vimeyers 29-05-2024 3 2   Download

Different from other resources, this volume offers a broad appeal to microbiologists, immunologists, and infectious disease specialists on Autoimmune Diseases. The volume covers topics such as skin and alopecia, Kidney, Liver, Paraneoplastic, Resolution of inflammation, Cardiovascular/systemic inflammation and atherosclerosis, Gut, Regulatory lymphocytes T, B, other and Rheumatic Disease. The volume is written by internationally renowned authors who are authorities in their respective fields.

1327p vimeyers 29-05-2024 2 2   Download

Part 1 book "Laboratory medicine - The diagnosis of disease in the clinical laboratory" includes contents: Concepts in laboratory medicine, methods, autoimmune disorders involving the connective tissue and immunodeficiency diseases, histocompatibility testing and transplantation, infectious diseases, toxicology, diseases of infancy and childhood, blood vessels.

241p dianmotminh01 17-05-2024 5 3   Download

Ebook "Complement therapeutics" highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis.

323p ladongphongthanh1008 22-04-2024 3 3   Download

Ebook "Tight junctions" highlight the importance of understanding TJ physiology in order to develop effective strategies for the treatment of pathological conditions such as cancer and autoimmune diseases. The first chapter of this book describes the evolution of the transporting epithelium from primitive metazoans to mammalian epithelia. Then, Chapters 2, 3, 4, 5, 6 and 7 review the characteristics and functionality of difi^erent proteins of theTJ studied in cell culture models, natural epithelia, mutant mice and heritable human diseases.

235p ladongphongthanh1008 22-04-2024 5 2   Download

Ebook "Systems biology of apoptosis" summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches.

211p ladongphongthanh1008 22-04-2024 4 2   Download

Ebook "Mesenchymal stem cells and immunomodulation" explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response.

94p tracanhphuonghoa1007 22-04-2024 4 2   Download

Ebook "Ten years of progress in GW/P body research" richly explores these original scienti fi c discoveries and many of the subsequent detailed studies of the components and functions of RNA processing that take place in GW/P bodies. The author list is truly impressive and reading the history will pique the interests of students and senior investigators, and hopefully, provide insights into future directions of the fi eld of RNA biology.

280p tracanhphuonghoa1007 22-04-2024 1 1   Download

Part 2 book "Textbook of oral medicine, oral diagnosis and oral radiology" includes content: Dental caries, pulp and periapical lesions; gingival and periodontal diseases; regressive alterations of teeth; systemic disorders and their clinical implications; bone diseases and fibro osseous lesions; autoimmune disorders; granulomatous diseases; sexually transmitted diseases; nutritional and metabolic disorders;.... and other contents.

495p muasambanhan10 06-04-2024 6 2   Download

Initial comments on the effectiveness of surgical treatment of vitiligo Research subjects and methods: A prospective study on 12 cases of vitiligo that were successfully treated with autologous pigment cell transplant surgery. Research period from September 2018 to October 2022 at the Center for Plastic Surgery, Surgery & Regeneration - Le Huu Trac National Burn Hospital.

9p vioraclene 31-03-2024 6 2   Download

The genetic and immunological factors that contribute to differences in susceptibility and progression between sub-types of inflammatory and autoimmune diseases continue to be elucidated. Inflammatory bowel disease and juvenile idiopathic arthritis are both clinically heterogeneous and known to be due in part to abnormal regulation of gene activity in diverse immune cell types.

16p vibransone 28-03-2024 2 2   Download

Rheumatoid arthritis is a common autoimmune disorder influenced by both genetic and environmental factors. Epigenome-wide association studies can identify environmentally mediated epigenetic changes such as altered DNA methylation.

12p vibransone 28-03-2024 3 2   Download

The immune system plays a fundamental role in development during pregnancy and early life. Alterations in circulating maternal and neonatal immune mediators have been associated with pregnancy complications as well as susceptibility to autoimmune and neurodevelopmental conditions in later life.

17p vibransone 28-03-2024 2 2   Download

For at least 300 years the immune system has been targeted to improve human health. Decades of work advancing immunotherapies against infection and autoimmunity paved the way for the current explosion in cancer immunotherapies.

10p vibransone 28-03-2024 2 1   Download

In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The objective of this study was to further investigate this shared genetic component.

13p vibransone 28-03-2024 5 2   Download

Endogenous retroelements (EREs) constitute about 42% of the human genome and have been implicated in common human diseases such as autoimmunity and cancer. The dominant paradigm holds that EREs are expressed in embryonic stem cells (ESCs) and germline cells but are repressed in differentiated somatic cells.

16p vibransone 28-03-2024 7 2   Download

Systemic sclerosis (SSc) is a genetically complex autoimmune disease mediated by the interplay between genetic and epigenetic factors in a multitude of immune cells, with CD4+ T lymphocytes as one of the principle drivers of pathogenesis.

17p vibransone 28-03-2024 3 2   Download