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Based vaccine candidate

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  • Subunit vaccines based on recombinant proteins have been effective in preventing infectious diseases and are expected to meet the demands of future vaccine development. Computational approach, especially reverse vaccinology (RV) method has enormous potential for identification of protein vaccine candidates (PVCs) from a proteome.

    pdf11p viwyoming2711 16-12-2020 5 0   Download

  • For decades we have been learning about the interplay between tumors and the immune system. Our knowledge seemed somewhat incomplete and indirect, like listening to the ocean waves through a shell. Only recently, cancer immunotherapy has started to become a reality, with Provenge (Dendreon Corporation, WA), an autologous antigen-presenting cell preparation, earning the approval of United States Food and Drug Administration (FDA) for the treatment of advanced prostate cancer in 2010.

    pdf228p wawawawawa 27-07-2012 71 17   Download

  • Immune system is composed of innate and adaptive responses and plays critical roles in cancer development and destruction. A century ago, Paul Ehrlich postulated that cancer would be quite common in long-lived organisms if not for the protective effects of immunity. About 50 years later, Burnet and Thomas proposed the concept of cancer immunosurveillance based on the experimental evidence of immune recognition of tumor antigens expressed on tumor cells (Dunn et al. 2004 ) . In 1971, the US Congress created a National Cancer Act – a War on Cancer.

    pdf489p hotmoingay 04-01-2013 50 11   Download

  • Characterization of transgene expression in adenoviral vector-based HIV-1 vaccine candidates

    pdf7p dauphong4 24-12-2011 31 2   Download

  • Computational scanning of peptide candidates that bind to a specific major histocompatibility complex (MHC) can speed up the peptide-based vaccine development process and therefore various methods are being actively developed.

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