Bi-layer sheet

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Báo cáo Y học: The effects of ring-size analogs of the antimicrobial peptide gramicidin S on phospholipid bilayer model membranes and on the growth of Acholeplasma laidlawii B

Wehave examined the effectsof three ring-sizeanalogsof the cyclicb-sheet antimicrobial peptidegramicidinS (GS) on the thermotropic phase behavior and permeability of phos-pholipid model membranes and on the growth of the cell wall-less Gram-positive bacteriaAcholeplasma laidlawiiB. These three analogs have ring sizes of 10 (GS10), 12 (GS12) or 14 (GS14) amino acids, respectively.

10p tumor12 22-04-2013 32 2 Download

Báo cáo Y học: Association of human tumor necrosis factor-related apoptosis inducing ligand with membrane upon acidiﬁcation

Tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) has been known to induce tumor-specific apoptosis and to share the structural and functional char-acteristics with the proteins of TNF family. Recently, the crystal structure of humanTRAIL showed that TRAIL is a homotrimeric protein whose subunits contain mainly b-sheets. We characterized the structural changes of recombinant human TRAIL induced byacidification and the biological implication of the structural characteristics at acidic pH in the interaction with the lipid bilayer. ...

8p tumor12 22-04-2013 47 2 Download