Bioenergetic

Department of Medical Biochemistry and Biology, University of Bari, Italy; 2Department of Zoology, Laboratory of Histology and Comparative Anatomy, University of Bari, Italy; 3Center for the Study of Mitochondria and Energy Metabolism (CNR) Bari, Italy Mitochondrial bioenergetic impairment has been found in the organelles isolated from rat liver during the prereplicative phase of liver regeneration.

9p system191 01-06-2013 35 4   Download

The synthesis of formyl-methanofuran and the reduction of the heterodisulfide (CoM-S-S-CoB) of coenzyme M (HS-CoM) and coenzyme B (HS-CoB) are two crucial, H2 -dependent reactions in the energy metabolism of meth-anogenic archaea. The bioenergetics of the reactionsin vivo were studied in chemostat cultures and in cell suspensions of Methanothermobacter thermautotrophicusmetabolizing at defined dissolved hydrogen partial pressures (pH2 ).

10p tumor12 20-04-2013 36 4   Download

The specificity of the Spodoptera frugiperda digestive b-glycosidase (Sfbgly50) for fucosides, glucosides and galactosides is determined by noncovalent interactions of glycone6-OHandglycone 4-OHwith the active-site residues Q39andE451.Site-directedmutagenesisandenzymesteady-state kinetics were described, showing that replacement of E451 with glutamine increased the preference of Sfbgly50 for glucosides in comparison to galactosides, whereas replacing E451 with serine had the opposite effect.

9p awards 05-04-2013 46 3   Download

Twin-arginine translocase (Tat) is involved in the translocation of fully folded proteins in a process that is driven by the proton motive force. In most prokaryotes, the Tat system transports only a small proportion of secretory proteins, and Tat substrates are often cofactor-containing proteins that require folding before translocation.

9p vinaphone15 28-02-2013 43 2   Download

Cockayne syndrome (CS) is a complex, progressive disease that involves neurological and developmental impairment and premature aging. The majority of CS patients have mutations in theCSBgene. The CSB protein is involved in multiple DNA repair pathways and CSBmutated cells are sensitive to a broad spectrum of genotoxic agents.

11p viettel02 22-02-2013 32 4   Download

Describing the molecular details of the multidrug efflux process of ABCB1, in particular the interdomain communication associated with bioenergetic coupling, continues to prove difficult. A number of investigations to date have implicated transmembrane helix 12 (TM12) in mediating communica-tion between the transmembrane domains and nucleotide-binding domains (NBDs) of ABCB1.

12p viettel02 19-02-2013 33 4   Download

Cytochromes of thec-type contain hemes covalently attached via one or, more generally, two thioether bonds between the vinyls of hemeband the thiols of cysteine residues of apocytochromes. This post-translational modi-fication relies on membrane-associated specific biogenesis proteins, referred to as cytochrome c maturation systems.

9p cosis54 09-12-2012 44 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Erythropoietin improves skeletal muscle microcirculation and tissue bioenergetics in a mouse sepsis model...

7p coxanh_3 25-10-2011 51 6   Download