Bottle necks

Pooled CRISPR screens are a powerful tool to probe genotype-phenotype relationships at genome-wide scale. However, criteria for optimal design are missing, and it remains unclear how experimental parameters affect results. Here, we report that random decreases in gRNA abundance are more likely than increases due to bottle-neck effects during the cell proliferation phase. Failure to consider this asymmetry leads to loss of detection power.

13p viarchimedes 26-01-2022 5 0   Download

The study is therefore proposed to identify the bottlenecks perceived by the respondents of Farmer Producer Organizations (FPO) in improving the livelihood of farming community by collecting information from the existing FPOs members.

4p angicungduoc8 07-11-2020 10 1   Download

The objective of this paper is to improve the productivity of the various assembly & machining lines. Productivity can be increased by reducing the total cycle time of the assembly lines of clutch servo assembly lines, finding the non-value added time, reducing the bottle neck time, line balancing in each assembly station, by supplying proper material flow and by improving the line layout

11p orianahuynh 06-06-2020 28 2   Download

Bài báo trình bày việc áp dụng Bottle Neck Feature(BNF) - một dạng đặc trưng của tín hiệu tiếng nói được trích chọn thông qua mạng neural (Neural Network) - cho nhận dạng tiếng nói tiếng Việt.

10p dieutringuyen 07-06-2017 63 5   Download

Effect of wollastonite nanofibers on the improvement of thermal conductivity coefficient of Medium-Density Fiberboard (MDF) was studied here to find a possible solution to decrease hot-press time as a bottle-neck during composite production. Nanowollastonite was applied at 10%, based on the dry weight of wood fibers. Density of the control MDF boards was 0.66 g/cm3. Thermal conductivity coefficient was measured using an apparatus based on Fourier’s Law for heat conduction.

5p thanhtoyz 17-10-2015 49 2   Download

In the past decades a renewed interest has been seen around optical wireless communications, commonly known as free-space optics (FSO), because of the ever growing demand for high-data-rate data transmission as to a large extent current applications, such as the high-definition (HD) contents and cloud computing, require great amount of data to be transmitted, hence, demanding more transmission bandwidth. Nowadays, the last mile problem continuous to be the bottle neck in the global communication network....

208p contentnew 12-04-2012 85 17   Download

Với kiến trúc đơn bộ xử lý: Tốc độ của bộ xử lý ngày càng được nâng cao và nhanh hơn so với tốc độ truy cập bộ nhớ . Hiện tượng thắt cổ chai (bottle-neck): trong các chu trình lệnh, CPU sẽ lãng phí một vài chu kỳ đồng hồ để chờ đợi quá trình truy cập bộ nhớ.

49p xuongrong_battien 16-10-2011 124 28   Download