Botulinum neurotoxin

The disease occur in children under 12 months [2]. This is a rare form of infection in Vietnamese infants. The key features of presentation were acute onset of bilateral cranial nerve palsies and symmetrical descending weakness in the absence of fever

6p viwalton 29-06-2024 3 1   Download

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin.

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Clostridium botulinum is an anaerobic, Gram-positive, rod-shaped bacterium that forms spores and the neurotoxin botulinum. It is best known for its toxin-induced flaccid paralytic disease, which is deadly without correct treatment. In this report, we show a completely different clinical course with fatal outcome.

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Part 1 book "Clostridial diseases of animals" includes content: Taxonomic relationships among the clostridia; general physiological and virulence properties of the pathogenic clostridia; brief description of animal pathogenic clostridia; toxins of histotoxic clostridia - Clostridium chauvoei, clostridium septicum, clostridium novyi, and clostridium sordellii; toxins of clostridium perfringens; toxins of clostridium difficile; clostridium botulinum and clostridium tetani neurotoxins,... and other contents.

176p muasambanhan01 13-12-2023 7 3   Download

Type 1 neurodegeneration with brain iron accumulation is a rare neurological disorder with estimated prevalence of one to two per million persons worldwide, characterized by progressive degeneration of basal gan‑ glia, globus pallidus, and reticular part of substantia nigra, produced by brain iron accumulation due to a defect in the gene producing pantothenate kinase 2.

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The sequence of gene encoding BoNT/B LC was approximately 98.8% identical to reference strains. Additionally, we analyzed the deduced amino acid sequences of the inferred proteins and identified a substitution that resulted in a frameshift and premature stop codon as previously found in a defective form of BoNT/B.

5p meyerowitz 25-12-2021 11 0   Download

Botulism is a naturally occurring disease, mainly caused by the ingestion of food contaminated by the botulinum neurotoxins (BoNTs). Botulinum neurotoxins are the most lethal. They are classified among the six major biological warfare agents by the Centers for Disease Control.

14p viuchiha2711 21-04-2020 12 0   Download

(bq) part 1 book "manual of botulinum toxin thera" presentation of content: the pretherapeutic history of botulinum neurotoxin, pharmacology of botulinum neurotoxins, treatment of cervical dystonia, botulinum neurotoxin in oromandibular dystonia, treatment of focal hand dystonia,...

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(bq) part 2 book "manual of botulinum toxin thera" presentation of content: treatment of stiff-person syndrome with botulinum neurotoxin, cosmetic uses of botulinum neurotoxins, hyperhidrosis, botulinum neurotoxin in wound healing, the use of botulinum neurotoxin in musculoskeletal pain and arthritis, botulinum neurotoxin in the gastrointestinal tract,...

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Botulinum neurotoxin type A (BoNT⁄A), the most toxic substance known to mankind, is produced by Clostridium botulinumtype A as a complex with a group of neurotoxin-associated proteins (NAPs) through polycis-tronic expression of a clustered group of genes. NAPs are known to protect BoNT against adverse environmental conditions and proteolytic digestion. Hemagglutinin-33 (Hn-33) is a 33 kDa subcomponent of NAPs that is resistant to protease digestion, a feature likely to be involved in the protec-tion of the botulinum neurotoxin from proteolysis. ...

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The seven serotypes ofClostridium botulinumneurotoxins (A–G) are the deadliest poison known to humans. They share significant sequence homo-logy and hence possess similar structure–function relationships. Botulinum neurotoxins (BoNT) act via a four-step mechanism, viz.,

19p cosis54 04-01-2013 23 3   Download

The botulinum neurotoxins (BoNTs) are the most potent protein toxins for humans. There are seven serotypes of BoNTs (A–G), based on a lack of cross-antiserum neutralization. The BoNT⁄C and BoNT⁄D serotypes include mosaic toxins that are organized as D–C and C–D toxins.

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A major unmet clinical need exists for long-acting neurotherapeutics to alleviate chronic pain in patients unresponsive to available nonaddictive analgesics. Herein, a new strategy is described for the development of potent and specific inhibitors of the neuronal exocytosis of transmitters and pain mediators that exhibit unique antinociceptive activity.

13p cosis54 09-12-2012 44 2   Download

The four-domain structure of botulinum neurotoxins (BoNTs) reflects their multistep intoxication process. The high toxicity of BoNTs primarily results from specific binding and uptake into neurons mediated by their 50-kDa cell-binding fragment (HC). X-ray crystallography data have revealed that the HCfragment consists of two domains of equal size, named the 25-kDa N-terminal half of HC(HCN) and the 25-kDa C-terminal half of HC(HCC).

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Botulism is a paralytic disease caused by potent protein neurotoxins elaborated by Clostridium botulinum. Illness begins with cranial nerve involvement and proceeds caudally to involve the extremities. Cases may be classified as (1) food-borne botulism, from ingestion of preformed toxin in food contaminated with C. botulinum; (2) wound botulism, from toxin produced in wounds contaminated with the organism; and (3) intestinal botulism, from ingestion of spores and production of toxin in the intestine of infants (infant botulism) or adults.

8p ozon_ozon 26-04-2012 41 5   Download

Harrison's Internal Medicine Chapter 134. Botulism Definition Botulism is a paralytic disease caused by potent protein neurotoxins elaborated by Clostridium botulinum. Illness begins with cranial nerve involvement and proceeds caudally to involve the extremities. Cases may be classified as (1) food-borne botulism, from ingestion of preformed toxin in food contaminated with C.

5p colgate_colgate 21-12-2010 101 13   Download