Calcium channel blocker

Hypertension is associated with the risk of prostate cancer (PCa) and its progression, however, it remains unclear whether antihypertensive medicines alter PCa risk or prognosis. This systematic review evaluated the role of calcium channel blockers (CCBs) and renin-angiotensin system (RAS) inhibitors in the risk and prognosis of PCa. This review was performed in line with PRISMA 2020 guidelines.

11p vishanshan 27-06-2024 2 1   Download

Part 1 book "Cardiac drug therapy" includes content: Beta blockers: The cornerstone of cardiac drug therapy - beta blocker controversies, angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, ACE inhibitor ARB controversies, calcium antagonists (calcium channel blockers). calcium antagonist controversies, diuretics, hypertension, hypertension controversies.

336p zizaybay1101 30-04-2024 5 2   Download

Calcium channel blocker overdose is usually very fatal and challenging to manage. The patients are usually asymptomatic on admission, but deteriorate very rapidly. Currently, there is no specific antidote, and the treatment is supportive requiring high level of critical care, and may necessitate extracorporeal membrane oxygenation. The use of high-dose insulin is reported to help stabilize the blood pressure and wean off inotropes.

4p viintuit 26-09-2023 2 0   Download

This study reports the design, synthesis, and calcium channel modulatory activity evaluation of a series of 14 novel fused 1,4-dihydropyridine derivatives. The molecular design of the compounds was based on modifications of nifedipine, which is a calcium channel blocker. The compounds were achieved by one-pot microwave-assisted reaction of 4,4-dimethyl-1,3-cyclohexanedione, 5-chlorosalicylaldehyde/3,5-dichlorosalicylaldehyde, an appropriate alkyl acetoacetate, and ammonium acetate in ethanol according to a modified Hantzsch reaction.

11p langthannam 29-12-2021 8 0   Download

There is a growing concern that the use of anti-hypertensives may be associated with an increased risk of cancer, but it remains uncertain for the association between anti-hypertensives and lung cancer risk, as well as their interaction with aspirin in chemoprotective effects.

9p vimahuateng 26-11-2021 7 1   Download

A higher density of tumor-infiltrating lymphocytes (TILs) can lead to greater therapeutic effects and improved prognoses in cancer treatment. Similar results have been observed in breast cancer, particularly in triplenegative breast cancer (TNBC) and human epidermal growth factor receptor 2-enriched breast cancer.

10p vikuala271 13-06-2020 8 1   Download

The reaction of lithiation of 2-bromo-4-(1,3-dioxolan-2-yl)-1,3-thiazole with in position 5 of the thiazole ring and double lithiation with t-butyllithium (t-BuLi) in positions 2 and 5 lithium diisopropylamide (LDA) are investigated.

8p tocectocec 25-05-2020 7 0   Download

Changes in antihypertensive drug treatment are paramount in the adequate management of patients with hypertension, still, there is little information regarding changes in antihypertensive drug treatment in Switzerland. Our aim was to assess those changes and associated factors in a population-based, prospective study

9p vienzym2711 03-04-2020 8 1   Download

Calcium channel blockers (CCBs) are widely used drugs that have a narrow therapeutic index. Even minor overdoses must be treated in-hospital due to the risk of severe hypotension and bradycardia.

8p vimax2711 30-03-2020 27 1   Download

The endothelium-derived hyperpolarizing factor (EDHF) response is a critical for the functioning of small blood vessels. We investigated the effect of streptozotocin-induced diabetes on the EDHF response and its possible role in the regulation of cardiac function. The vasorelaxant response to ACh- or NS309- (direct opener endothelial small- (SKCa)- and intermediateconductance (IKCa) calcium-activated potassium channels; main components of EDHF response) were measured in pressurized mesenteric arteries (diameter 300–350 lm). The response to 1 lM ACh was reduced in diabetes (84.8 ± 2.

9p kethamoi1 17-11-2019 13 0   Download

Limited progress has been made in the quest to identify both selective and non-toxic T-type calcium channel blocking compounds. The present research work was directed toward slaking the same by identifying the selective three dimensional (3D) pharmacophore map for T-type calcium channel blockers (CCBs). Using HipHop module in the CATALYST 4.10 software, both selective and non-selective HipHop pharmacophore maps for T-type CCBs were developed to identify its important common pharmacophoric features.

14p kequaidan1 16-11-2019 14 0   Download

(BQ) Part 1 of the document Cardiovascular diseases - From molecular pharmacology to evidence-Based therapeutics presents the following contents: General introduction, dyslipidemias, hypertension and multitasking cardiovascular drugs.

270p thangnamvoiva4 01-07-2016 38 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Hyperinsulinemia-euglycemia therapy: a useful tool in treating calcium channel blocker poisoning...

2p thulanh17 24-10-2011 48 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Bench-to-bedside review: Hyperinsulinaemia/euglycaemia therapy in the management of overdose of calcium-channel blockers...

6p thulanh17 24-10-2011 49 3   Download

Bệnh nhân 83 tuổi đàn bà, caucasian, trại nội thuơng hỏi ý kiến vì thiếu máu Hct 29%, MCV bình thuờng, MCH bình thường, Platelet bình thuờng (normocytic normochromic anemia), TB máu tráng 18 nghìn /mm3, nhưng bnhân đang uống Prednisone. Thử nghiệm gan, thận, LDH, Serum B12, Folate, Iron, TIBC, Ferritin, Protein electrophoresis, Serum immunofixation: normal, Nước đái: normal. Dòm phết máu dưới ống dầu (phóng đại 1000 lần): tb máu không thấy gì lạ, chỉ thấy hơi anisocytosis, poikilocytosis. Không thấy tb máu đỏ còn nhân (nucleated red cells). Bnhân uống Furosemide, Calcium channel blocker.

7p nganluong111 14-04-2011 78 2   Download

Thuốc Beta-Blockers Trị Cao Huyết Áp Trong báo Jl Family Practice tháng giêng 2008 có một bài của 2 bác sĩ Srah-Anne Schumann và John Hickner, thuộc Đại Học Y Khoa Chicago, nói về người già dùng thuốc beta-blockers trị cao máu. Trong tường trình có nhắc lại hướng dẫn JNC 7 khuyến cáo bệnh nhân uống thuốc lợi tiểu trước nhất và, nếu cần sau đó, dùng thêm những thuốc trị cao huyết áp beta-blockers, calcium-channel blockers, angiotensinconverting enzyme inhibitors, và angiotensin receptor blockers. Nghiên cứu Cochrane 2007 so sánh dùng thuốc trị cao máu betablockers cho bệnh nhân từ...

3p sinhtobo111 13-04-2011 104 3   Download

Hypertension and coronary heart disease (CHD) are of great importance. Hypertension affects above 20% of the total population of the USA with its major impact on those over age 50. CHD is the cause of death in 30% of males and 22% of females in England and Wales. Management requires attention to detail, both clinical and pharmacological. The way drugs act in these diseases is outlined and the drugs are described according to class.

18p bigbaby87 03-09-2010 102 12   Download