Cancer cell collections

Xem 1-14 trên 14 kết quả Cancer cell collections
  • Cell culture is practiced extensively throughout the world today. The techniques required to allow cells to grow and be maintained outside the body have been developed throughout the 20th century. In the 50 years since the publication of the first human cancer cell line, HeLa (1), thousands of cell lines representing most of the spectrum of human cancer have been derived. These have provided tools to study in depth the biochemistry and molecular biology associated with individual cancer types and have helped enormously in our understanding of normal as well as cancer cell physiology.

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  • Storage of putative stem/progenitor cells is also an attractive research target in tissue engineering. Collection of cells for tissue engineering is less invasive than conventional tissue or organ transplantation. However, repetitive collection of cells can stress patients. If the stem/progenitor cells could be stored, it is possible that they could be repeatedly used for future therapy, reducing the burden and the cost to patients. The concept of banking stem/progenitor cells in storage is not new. Stem/progenitor cell populations decrease in size with age (D'Ippolito et al.

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  • “Advances in Prostate Cancer” is an addition to the InTech collection of three previous books about prostate cancer and aims at providing a comprehensive overview of specific aspects of the latest research and current knowledge relating to this tumor entity to scientists and clinicians. For this purpose a series of research articles, clinical investigations and reviews that deal with a wide range of relevant aspects pertinent to the epidemiology, diagnosis, patient care, treatment and basic biology of prostate cancer were included.

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  • The need for a comprehensive NCI-wide terminology arose because NCI staff requires access to timely and accurate information about activities related to the scientific mission of the Institute. The collection, storage and retrieval of data related to NCI research programs is necessary to analyze, manage, and report about these activities. Though centralized coding of NCI-supported research-related activities met some of these needs, supplementary data coding had become common.

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  • Those of us involved in the healthcare of women have seen a remarkable transformation in screening techniques for cervical cancer and its precursors since the mid 1990s.  The staid old Pap smear technique of scraping cells from the cervix with a wooden spatula and cotton-tipped applicator and smearing them onto a glass slide is a thing of the past in most practices. We now use plastic collection devices to transfer cells from the cervix into a preservative which is sent to the lab for liquidbased cytology and reflex human papillomavirus (HPV) testing.

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  • Today’s public sculpture will become tomorrow’s historic monu- ments. Just as communities work now to preserve their existing sculp- ture and monuments, future generations will be preserving the art created today. The problems that have affected collections of older works will afflict new creations as well. Positive public support is crucial to the survival of outdoor sculpture and can be heightened through education and community participation.

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  • From a health perspective, reducing exposure to indoor air pollution (IAP) is and should be the primary objective of household energy interventions. Measuring IAP levels is particularly important given the difficulty in assessing health outcomes directly. Thus reductions in pollution levels can be assessed as a proxy for likely reductions in health outcomes. The Indoor Air Pollution Monitoring module consists of three presentations as well as extensive hands-on training to launch, place and collect the instruments and to download and process the resulting data.

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  • We especially paid attention not to distend the bladder too much to prevent a high irrigation pressure and a resultant TUR syndrome. Special attention was paid to avoid the injury to Santorini’s plexus and the rectum. The procedure was started from the 12 o’clock position, dividing the prostate into 6 parts, and resected specimens were collected separately to examine the distribution of cancer. The seminal vesicle was partially resected at its attached part to the prostate between the 4 and 8 o’clock positions to determine the invasion of cancer.

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  • Adipose tissue is an endocrine organ made up of adipocytes, various stro-mal cells, resident and infiltrating immune cells, and an extensive endo-thelial network. Adipose secretory products, collectively referred to as adipokines, have been identified as contributors to the negative conse-quences of adipose tissue expansion that include cardiovascular disease, diabetes and cancer.

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  • The advantages of diagnostic cytology are that it is a non-invasive, simple procedure, helps in faster reporting, is relatively inexpensive, has high population acceptance and facilitates cancer screening in the field. Diagnostic cytology can be carried out by different methods, which includes collection and examination of exfoliated cells such as vaginal scrapes, sputum, urine, body fluids etc. Collection of cells by brushing, scraping or abrasive techniques is usually employed to confirm or exclude malignancy.

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  • Loss of functional emerin, a nuclear membrane protein, causes X-linked recessive Emery–Dreifuss muscular dystro-phy. In a yeast two-hybrid screen, we found that emerin interacts with Btf, a death-promoting transcriptional repressor, which is expressedat high levels in skeletalmuscle. Biochemical analysis showed that emerin binds Btf with an equilibriumaffinity (KD)of100 nM. Using a collection of 21 clustered alanine-substitution mutations in emerin, the resi-dues required for binding to Btf mapped to two regions of emerin that flank its lamin-binding domain. ...

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  • Genetic and proteomic approaches have led to the identification of 32 pro-teins, collectively called peroxins, which are required for the biogenesis of peroxisomes. Some are responsible for the division and inheritance of per-oxisomes; however, most peroxins have been implicated in the topogenesis of peroxisomal proteins. Peroxisomal membrane and matrix proteins are synthesized on free ribosomes in the cytosol and are imported post-trans-lationally into pre-existing organelles (Lazarow PB & Fujiki Y (1985) Annu Rev Cell Biol1, 489–530 [1])....

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  • Management of Occult and Stage 0 Carcinomas In the uncommon situation where malignant cells are identified in a sputum or bronchial washing specimen but the chest radiograph appears normal (TX tumor stage), the lesion must be localized. More than 90% can be localized by meticulous examination of the bronchial tree with a fiberoptic bronchoscope under general anesthesia and collection of a series of differential brushings and biopsies. Often, carcinoma in situ or multicentric lesions are found in these patients.

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  • Abnormal reproductive development in males has been linked to environmen- tal contaminant exposure in a wide variety of vertebrates. These include humans, rodent models, and a large number of comparative wildlife species. In human males, abnormal reproductive development can manifest as a suite of symptoms, described collectively as testicular dysgenesis syndrome (TDS). TDS is also described as demasculinization or feminization of the male phenotype.

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