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Cancer stem cell
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YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers. In tumor cells, they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies.
18p
vishanshan
27-06-2024
1
1
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Uveal melanoma (UVM) is the most common primary intraocular tumor in adults, with a median survival of 4–5 months following metastasis. DNA damage response (DDR) upregulation in UVM, which could be linked to its frequent activation of the PI3K/AKT pathway, contributes to its treatment resistance.
11p
vishanshan
27-06-2024
1
1
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Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors.
11p
vishanshan
27-06-2024
3
1
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Autologous stem-cell transplantation (ASCT) remains a beneficial approach for patients with newly diagnosed multiple myeloma (NDMM) in the age of novel therapeutic agents. Nevertheless, limited real-world data is available to establish criteria for identifying high-risk ASCT patients.
11p
vishanshan
27-06-2024
1
1
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Biliary tract cancer (BTC) is a relatively rare but aggressive gastrointestinal cancer with a high mortality rate. Cancer stem cell (CSC) populations play crucial roles in tumor biology and are responsible for the low response to anti-cancer treatment and the high recurrence rate. This study investigated the role of Transgelin-2 (TAGLN2), overexpressed in CSC in BTC cells, and analyzed its expression in patient tissues and serum to identify potential new targets for BTC.
15p
vishanshan
27-06-2024
1
1
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A high expression pattern of minichromosome maintenance 2 (MCM2) has been observed in various cancers. MCM2 is a protein involved in the cell cycle and plays a role in cancer growth and differentiation by binding to six members of the MCM subfamily. The MCM protein family includes MCM2 through MCM7.
12p
vishanshan
27-06-2024
1
1
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Several publications suggest that UTP11 may be a promising gene engaged for involvement of hepatocellular carcinoma (HCC) pathology. However, there are extremely limited biological, mechanistic and clinical studies of UTP11 in HCC.
13p
vishanshan
27-06-2024
1
1
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GEFT is a key regulator of tumorigenesis in rhabdomyosarcoma (RMS), and overexpression of GEFT is significantly correlated with distant metastasis, lymph node metastasis, and a poor prognosis, yet the underlying molecular mechanism is still poorly understood. This study aimed to investigate and validate the molecular mechanism of GEFT-activated lncRNAs in regulating mTOR expression to promote the progression of RMS.
16p
vishanshan
27-06-2024
1
1
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RACGAP1 not only indicates poor prognosis and limited immunotherapy benefits but also serves as a potential targeted biomarker influencing tumor stemness. Investigating the key genes and mechanisms that influence stemness in lung adenocarcinoma.
13p
vishanshan
27-06-2024
1
1
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Myelodysplastic syndrome (MDS) is known to arise through the pathogenic bone marrow mesenchymal stem cells (MSC) by interacting with hematopoietic stem cells (HSC). However, due to the strong heterogeneity of MDS patients, it is difficult to find common targets in studies with limited sample sizes. This study aimed to describe sequential molecular changes and identify biomarkers in MSC of MDS transformation.
14p
vikoch
27-06-2024
1
1
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In this study, we evaluated the impact of breast cancer cells on the characteristics of adipose-derived stem cells (ADSCs) under in vivo conditions. ADSCs were obtained from Balb/c mice three consecutive weeks after transplantation with 1×106 MCF7 cells.
6p
viambani
18-06-2024
2
0
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Ebook "Human cell transformation: Role of stem cells and the microenvironment" highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields.
239p
ladongphongthanh1008
22-04-2024
1
1
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Ebook "Stem cells & regenerative medicine: From molecular embryology to tissue engineering" is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications.
632p
ladongphongthanh1008
22-04-2024
6
3
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Ebook "Male germline stem cells: Developmental and regenerative potential" covers many of the fundamental issues now being explored by today’s generation of stem cell researchers, including the field’s potential for regenerative medicine. Ranging from an assessment of the pluripotency of primordial germ cells and their possible applications in treating testicular cancer, to the recovery of once-mordant fertilization-competent sperm, this volume has it all.
269p
ladongphongthanh1008
22-04-2024
4
1
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Ebook "Handbook of vascular biology techniques" will appeal to students, researchers and medical professionals working in all vascular-linked fields such as cardio- and cerebrovascular, cancer and dementia. Each chapter contains helpful sections on trouble shooting, additional notes and links, supporting the reader to carry out protocols.
466p
ladongphongthanh1008
22-04-2024
1
1
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Ebook "Systems biology of tumor dormancy" was to present research advances in the field of tumor dormancy from diverse experimental and clinical perspectives using biological, mathematical, and computational approaches.
298p
ladongphongthanh1008
22-04-2024
3
1
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Ebook "Cancer stem cells in solid tumors" represents a detailed overview of cancer stem cells and their role in solid cancers. Comprised of 24 chapters, this volume will provide readers with a comprehensive understanding of this important and evolving field.
479p
tracanhphuonghoa1007
22-04-2024
2
2
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Ebook "Mesenchymal stem cells and immunomodulation" explores mesenchymal stem cells (MSCs) and their potential to suppress immune-mediated inflammation. The chapters examine applications in autoimmune diseases such as lupus, rheumatoid arthritis and multiple sclerosis; blood cancers such as leukemia and lymphoma; and reproductive complications, specifically pre-term labor and use of MSCs in vitro and in animal models to discover methods of suppressing the causal inflammatory response.
94p
tracanhphuonghoa1007
22-04-2024
3
2
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Ebook "Prominin-1 (CD133): New insights on stem & cancer stem cell biology" was conceived to celebrate the fi fteenth anniversary of the discovery of prominin-1, also known in the medical fi eld as CD133. This book is composed of 15 chapters that will describe, on one hand, the molecular and cellular biology of prominin-1 and other members of the prominin family and, on the other hand, the importance of this molecule in the medical fi eld as a valuable marker of stem and cancer stem cells.
255p
tracanhphuonghoa1007
22-04-2024
4
1
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Ebook "Prostate cancer: Biochemistry, molecular biology and genetics" provides an up-to-date review of the biochemistry, molecular biology, and genetic changes in prostate cells that are the driving forces in the initiation and progression of cancer. It includes an overview by experts in the field of cell-cell interactions, including stem cells, reactive Stromal cells and membrane lipid rafts that are instrumental in the initiation and progression of prostate cancer.
517p
tracanhphuonghoa1007
22-04-2024
2
2
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