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Candidate recombination
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Familial ovarian cancer (OC) cases not harbouring pathogenic variants in either of the BRCA1 and BRCA2 OC-predisposing genes, which function in homologous recombination (HR) of DNA, could involve pathogenic variants in other DNA repair pathway genes.
26p
vibransone
28-03-2024
2
2
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High-resolution mapping of the loci (QTN) responsible for genetic variation in quantitative traits is essential for positional cloning of candidate genes, and for effective marker assisted selection. The confidence interval (QTL) flanking the point estimate of QTN-location is proportional to the number of individuals in the mapping population carrying chromosomes recombinant in the given interval.
16p
vinarcissa
21-03-2023
2
1
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In this study, alkyl hydroperoxide reductase (AhpC) from M. bovis was evaluated as a new candidate vaccine antigen against TB in BALB/c mice model. The ahpC gene was amplified from M.bovis genome, cloned, and expressed in Escherichia coli. Vaccine antigen AhpC was formulated with Montanide ISA 61 VG, an oil-based emulsion adjuvant. Both IgG and IL-12 responses were observed in mice after administering the formulation both as a subunit vaccine alone and also as a booster vaccine for BCG immunization.
14p
lyhuyenthu
31-01-2023
6
2
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Herbicide tolerance is an important trait that allows effective weed management in wheat crops. Genetic knowledge of metribuzin tolerance in wheat is needed to develop new cultivars for the industry. Here, we evaluated metribuzin tolerance in a recombinant inbred line (RIL) mapping population derived from Synthetic W7984 and Opata 85 over two consecutive years to identify quantitative trait loci (QTL) contributing to the trait.
11p
vihagrid
30-01-2023
8
3
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The development of an influenza vaccine for poultry that provides broadly protective immunity against influenza H5Nx viruses is a challenging goal. L. lactis/pNZ8149-HA1-M2 can serve as a promising vaccine candidate in poultry industry for providing protection against H5Nx virus infection in the field application.
12p
vidarwin
22-02-2022
12
1
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The mapping resolution of genome-wide association studies (GWAS) is limited by historic recombination events and effects are often assigned to haplotype blocks rather than individual SNPs. It is not clear how many of the SNPs in the block, and which ones, are causative.
6p
vialfrednobel
29-01-2022
10
1
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Optimum flowering time is a key agronomic trait in Brassica napus. To investigate the genetic architecture and genetic regulation of flowering time in this important crop, we conducted quantitative trait loci (QTL) analysis of flowering time in a recombinant inbred line (RIL) population, including lines with extreme differences in flowering time, in six environments, along with RNA-Seq analysis.
14p
vigiselle2711
30-08-2021
9
1
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Familial adenomatous polyposis is an inherited genetic disease, characterized by colorectal polyps. It is caused by inactivating mutations in the Adenomatous polyposis coli (Apc) gene. Mice carrying a nonsense mutation in the Apc gene at R850, which is designated ApcMin/+ (Multiple intestinal neoplasia), develop intestinal adenomas.
18p
vijeeni2711
24-07-2021
15
0
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Oat (Avena sativa L.) is a recognized health-food, and the contributions of its different candidate Agenome progenitor species remain inconclusive. Here, we report chloroplast genome sequences of eleven Avena species, to examine the plastome evolutionary dynamics and analyze phylogenetic relationships between oat and its congeneric wild related species.
20p
vijichea2711
28-05-2021
19
1
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Subunit vaccines based on recombinant proteins have been effective in preventing infectious diseases and are expected to meet the demands of future vaccine development. Computational approach, especially reverse vaccinology (RV) method has enormous potential for identification of protein vaccine candidates (PVCs) from a proteome.
11p
viwyoming2711
16-12-2020
13
0
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Many computational tools that detect recombination in viruses are not adapted for the ongoing genomic revolution. A computational tool is needed, that will rapidly scan hundreds/thousands of genomes or sequence fragments and detect candidate recombination events that may later be further analyzed with more sensitive and specialized methods.
8p
vioklahoma2711
19-11-2020
8
0
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BRCA1/2 germline mutation related cancers are candidates for new immune therapeutic interventions. This study was a hypothesis generating exploration of genomic data collected at diagnosis for 19 patients.
16p
vijakarta2711
09-06-2020
7
1
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Bluetongue is an arthropod-borne, non-contagious viral disease of domestic and wild ruminants. In the present study, truncated VP2 protein of BTV serotype 23 (BTV-23) was expressed in a prokaryotic expression system and assessed for its potential use as a candidate for the development of serotype-specific BTV diagnostics assay. The expression of the VP2 protein was carried out in E. coli BL21 Codon Plus (DE3) cells using the pET32a expression vector.
8p
cothumenhmong5
17-05-2020
7
1
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Although chickpea (Cicer arietinum L.), an important food legume crop, is sensitive to salinity, considerable variation for salinity tolerance exists in the germplasm. To improve any existing cultivar, it is important to understand the genetic and physiological mechanisms underlying this tolerance.
15p
vihashirama2711
21-05-2020
18
2
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Exploring the natural occurring genetic variation of the wild barley genepool has become a major target of barley crop breeding programmes aiming to increase crop productivity and sustainability in global climate change scenarios.
20p
viharuno2711
24-04-2020
14
0
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Poor and inconsistent yields of the Pigeonpea cultivation across different environments grown in respective seasons reduce the economic benefits for the farmers. Besides tolerances/ resistance to abiotic and biotic stresses, plant type and seed yield components of Pigeonpea are the principal determinants of the consistent yields. The contemporary research was orchestrated for the identification of QTLs for plant type and seed yield components.
13p
cothumenhmong3
22-02-2020
38
0
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Ge is a potential candidate for the realization of Si-based light sources that are compatible with CMOS technology. Electron doping in Ge is an efficient method to modify its band gap structure to enhance the radiative recombination of Ge film. Post growth thermal treatment is a necessary step to activate the dopants and ameliorate the film’s crystal quality.
5p
vixyliton2711
12-04-2019
21
0
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Escherichia coli is an extensively used host for the production of recombinant proteins, making its N-terminal methionine aminopeptidase (MAP) an attractive candidate for studies on posttranslational protein processing. The present study describes the recombinant production and properties of MAP from the DH5α strain of E. coli.
12p
nutifooddau
27-01-2019
25
1
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(bq) part 2 book “update on production of recombinant therapeutic protein - transient gene expression” has content: optimisation of transient gene expression for therapeutic protein production, clinical applications of the transient gene expression.
97p
dien_vi09
21-10-2018
38
1
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2¢,5¢-oligoadenylate (2-5A) synthetases are known as components of the interferon-induced cellular defence mechanism in mammals. The existence of 2-5A synthetases in the evolutionarily lowest multicellular animals, the marine sponges, has been demonstrated and the respective candidate genes from Geodia cydoniumandSuberites domunculahave been identified.
13p
galaxyss3
19-03-2013
35
2
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