Cannabinoids

New psychoactive substances (NPS) continue to emerge in the drug market every year, becoming a global threat to public health and safety. These compounds are mostly synthetic cannabinoids and designer cathinones. However, synthetic opioids have appeared on the recreational drug markets in recent years, particularly fentanyl and its derivatives (“fentanyls”).

11p viginny 23-12-2022 6 2   Download

Age-adjusted US total pediatric cancer incidence rates (TPCIR) rose 49% 1975–2015 for unknown reasons. Prenatal cannabis exposure has been linked with several pediatric cancers which together comprise the majority of pediatric cancer types. We investigated whether cannabis use was related spatiotemporally and causally to TPCIR.

33p vianrose2711 27-04-2021 10 0   Download

Some of cannabinoids, which are chemical compounds contained in marijuana, are immunosuppressive. One of the receptors, CB receptor 1 (CB1), is expressed predominantly by the cells in the central nervous system, whereas CB receptor 2 (CB2) is expressed primarily by immune cells.

10p viannito2711 20-04-2021 9 1   Download

There are two well-characterised isoforms of cannabinoid receptor; CB1 and CB2 and of these CB2 is under active investigation as a potential target for treatment of the chronic pain associated with widespread and intractable joint diseases osteoarthritis and rheumatoid arthritis.

5p viannito2711 20-04-2021 8 1   Download

Arthritis pain is reported as one of the most common reasons for persons using medical herbal cannabis in North America. “Severe arthritis” is the condition justifying legal use of cannabis in over half of all authorizations in Canada, where cannabis remains a controlled substance.

6p viannito2711 20-04-2021 5 0   Download

Electronic cigarettes/e-cigarettes (ECs), or vaping, is currently the most popular form of smoking amongst youth in the United States. ECs are battery-powered devices that vaporize a liquid that comes in small cartridges, or pods, that contain various chemicals, nicotine, and an array of flavors that can be modified to include cannabinoids (THC).

6p vimaine2711 26-03-2021 6 1   Download

It has been previously demonstrated in several cancer models, that Dronabinol (THC) may have anti-tumor activity – however, controversial data exists for acute leukemia. We have anecdotal evidence that THC may have contributed to disease control in a patient with acute undifferentiated leukemia.

12p vinaypyidaw2711 26-08-2020 18 1   Download

The anti-tumor properties of cannabinoids have been investigated in many in vitro and in vivo studies. Many of these anti-tumor effects are mediated via cannabinoid receptor types 1 and 2 (CB1 and CB2), comprising the endocannabinoid system (ECS).

17p vibaku2711 22-07-2020 9 1   Download

Population-based studies suggest increasing rates of concurrent use of vaping products that contain either nicotine or cannabinoids. The aim of this pilot study was to test in vitro the acute inhalation toxicity of vaporized flavored and unflavored nicotine solutions co-administered with cannabidiol (CBD).

6p vivientiane2711 30-06-2020 17 1   Download

Cannabis possesses a rich spectrum of phytochemicals i.e. cannabinoids, terpenes and phenolic compounds of industrial and medicinal interests. Most of these high-value plant products are synthesised in the disk cells and stored in the secretory cavity in glandular trichomes.

12p vishikamaru2711 29-04-2020 10 1   Download

Significant interest has emerged in the therapeutic and interactive effects of different cannabinoids. Cannabidiol (CBD) has been shown to have anxiolytic and antipsychotic effects with high doses administered orally.

8p vienzym2711 03-04-2020 10 1   Download

Cannabinoid receptor 2 (CB2) is expressed predominantly in the immune system, particularly in plasma cells, raising the possibility that targeting the CB2 pathway could yield an immunomodulatory effect. Although the role of CB2 in mediating immunoglobulin class switching has been reported, the effects of targeting the CB2 pathway on immunoglobulin secretion per se remain unclear.

8p vienzym2711 03-04-2020 6 0   Download

“Legal highs” are novel psychoactive substances that have evaded statutory control. Synthetic cannabinoid compounds with adamantane moieties have recently been identified, which have high potency at target receptors and are undetectable on conventional toxicology testing.

4p vienzym2711 30-03-2020 7 1   Download

Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was developed as a potential analgesic compound.

11p vienzym2711 30-03-2020 8 0   Download

Cannabinoids elicit complex hemodynamic responses in experimental animals that involve both peripheral and central sites. Centrally administered cannabinoids have been shown to predominantly cause pressor response. However, very little is known about the mechanism of the cannabinoid receptor 1 (CB1R)-centrally evoked pressor response. In this review, we provided an overview of the contemporary knowledge regarding the cannabinoids centrally elicited cardiovascular responses and the possible underlying signaling mechanisms.

9p kethamoi1 17-11-2019 17 1   Download

In this paper we review some of the novel aspects of cannabis and cannabinoids in relation to their legal situation, changes in their composition and forms of cannabis use, the concept of medical cannabis, and synthetic cannabinoids as new psychoactive substances (NPS).

10p vihasaki2711 12-11-2019 12 1   Download

(bq) part 1 book “cannabis - a clinician’s guide” has contents: cannabinoids and the entourage effect, cannabis and addiction, what should we tell our patients about marijuana, cannabinoid medications for treatment of neurological disorders, terpenes,… and other contents.

173p tieu_vu15 07-09-2018 25 1   Download

Cannabinoid receptors and their endogenous ligands, the endocannabinoids, have been detected in several blood immune cells, including monocytes/macrophages, basophils and lymphocytes. However, their presence in dendritic cells, which play a key role in the initiation and development of the immune response, has never been investigated.

8p system191 01-06-2013 24 2   Download

If camels and other stock can be based far away from a water source, the total area available for grazing is greatly increased, the stocking rate can be lowered and the dangers of environmental degradation are reduced. In simple terms, a doubling of the interval between successive visits to water results in a four-fold increase in the area available for pasture, with a corresponding reduction in grazing pressure. More especially, the time period between successive waterings has an important bearing on the carrying capacity and the degradation risk of a given area.

70p conduongdinhmenh 07-05-2013 43 2   Download

Le Centre de Développement des Ressources de la Terre (l'un des organismes scientifiques de l'Administration Britannique de Développement Outremer) apporte son aide aux pays en voie de développement en matière de cartographie, recherche et evaluation des ressources de la terre et fourni t des recommandations quant ä l'exploitation de ces ressources pour le développement de l'agriculture, l'élevage et la sylviculture.

29p thieubaotrang 23-04-2013 48 5   Download