Cell apoptosis

One-third of diffuse large B-cell lymphoma (DLBCL) patients suffer relapse after standard treatment. Eukaryotic initiation factor 3a (eIF3a) is a key player in the initial stage of translation, which has been widely reported to be correlated with tumorigenesis and therapeutic response. This study aimed to explore the biological role of eIF3a, evaluate its prognostic and therapeutic potential in DLBCL.

16p vishanshan 27-06-2024 2 1   Download

PANoptosis is a specific type of inflammatory programmed cell death (PCD) modality that can be involved in three key modes of cellular programmed cell death-pyroptosis, apoptosis and necroptosis.

13p vishanshan 27-06-2024 1 1   Download

GBM is the most frequent malignant primary brain tumor in humans. The CLEC19A is a member of the C-type lectin family, which has a high expression in brain tissue. Herein, we sought to carry out an in-depth analysis to pinpoint the role of CLEC19A expression in GBM.

20p vishanshan 27-06-2024 2 1   Download

NUP155 is reported to be correlated with tumor development. However, the role of NUP155 in tumor physiology and the tumor immune microenvironment (TIME) has not been previously examined. This study comprehensively investigated the expression, immunological function, and prognostic significance of NUP155 in different cancer types.

22p vikoch 27-06-2024 3 1   Download

Osteosarcoma (OS) is one of the most common aggressive bone malignancy tumors in adolescents. With the application of new chemotherapy regimens, finding new and effective anti-OS drugs to coordinate program implementation is urgent for the patients of OS.

11p vikoch 27-06-2024 2 1   Download

Part 1 book "Rang and Dale's pharmacology" includes content: Cell proliferation, apoptosis, repair and regeneration; cellular mechanisms; method and measurement in pharmacology; drug absorption and distribution; drug metabolism and elimination; pharmacokinetics; pharmacogenetics, pharmacogenomics and ‘personalised medicine’; chemical mediators and the autonomic nervous system,... and other contents.

357p dianmotminh03 03-06-2024 2 0   Download

Among all types of DNA damage, DNA double-strand breaks (DSBs) are considered the most deleterious form induced by either endogenous factors (oxi-dative damages, mismatches, altered chromatin structures, and missing, or modified nucleotides) or exogenous factors, i.e., ultraviolet (UV) radiation, ionizing radiation (IR), and chemicals or drugs. This study aimed: To evaluate the effect of DNAPKi NU7441 on the HCT116 cell line.

11p vijaychest 16-05-2024 2 1   Download

. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.

10p dianmotminh02 03-05-2024 2 2   Download

Ebook "Necrotic cell death" presents comprehensive coverage of necrosis from recognized experts from leading academic and medical institutions around the world. ​In contrast to apoptosis, well-defined as a form of programmed cell death, necrosis used to be considered as accidental (i.e., non-programmed) cell death, usually in response to a severe injury. Accumulating evidence now suggests, however, that necrosis is also programmed and controlled by distinctive "death machinery" in response to various stimuli like oxidative stress or DNA damage.

402p ladongphongthanh1008 22-04-2024 3 1   Download

Ebook "Systems biology of apoptosis" summarizes all current achievements in this emerging field. Apoptosis is a process common to all multicellular organisms. Apoptosis leads to the elimination of cells via a complex but highly defined cellular programme. Defects in the regulation of apoptosis result in serious diseases such as cancer, autoimmunity, AIDS and neurodegeneration. Recently, a substantial step forward in understanding the complex apoptotic pathways has been made by utilising systems biology approaches.

211p ladongphongthanh1008 22-04-2024 4 2   Download

Ebook "Cell death signaling in cancer biology and treatment" is to describe state-of-the-art approaches and future opportunities for achieving this goal by targeting mechanisms and pathways that regulate cancer cell death. In this book, molecular defects in cell death signaling that characterize cancer cells, including dysregulation of cell death due to overexpression/hyperactivation of oncoproteins, as well as the loss of tumor suppressor proteins will be described.

412p tracanhphuonghoa1007 22-04-2024 2 1   Download

Ebook "Breast cancer chemosensitivity" include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents.

187p tracanhphuonghoa1007 22-04-2024 3 1   Download

Ebook "The long and short noncoding RNAs in cancer biology" conveys a comprehensive knowledge of long and short ncRNAs in cancer regulation and their potentials as diagnostic biomarkers and therapeutic targets. Topics covered include the molecular mechanisms of various classes of ncRNAs (with emphasis on long non-coding RNAs and microRNAs) in cancer, the functional roles of ncRNAs in regulating different cancer hallmarks (including proliferation, apoptosis, stem-cell properties, epithelial-mesenchymal transition, metabolism, angiogenesis, tumor-host interactions and therapeutic resistance).

455p tracanhphuonghoa1007 22-04-2024 4 2   Download

Recent work has reported that the activation of the p53 pathway in primary cells hampers the efficiency of genome editing by CRISPR/Cas9 via induction of apoptosis or cell cycle arrest. These findings highlight the importance of wholly comprehending cellular responses to programmable nucleases in therapeutically relevant cell types to fulfill the promise of genome editing for therapeutic applications for human diseases.

4p vibransone 28-03-2024 4 2   Download

Ebook "Natural compounds as inducers of cell death: Volume 1" gives a multi-disciplinary approach into the anti-cancer research field related to natural products and dietary compounds. Mainly, it covers the area of antitumor activity through an in-depth description of the cytotoxic, anti-inflammatory and anti-oxidant properties in cancer, inflammatory and cardio-vascular diseases.

512p manmanthanhla0201 26-02-2024 5 1   Download

Part 1 book "Rang and Dale's pharmacology" includes content: How drugs act, how drugs act, how drugs act, how drugs act, cell proliferation, apoptosis, repair and regeneration, cellular mechanisms, method and measurement in pharmacology, absorption and distribution of drugs, drug metabolism and elimination, pharmacokinetics, individual variation, pharmacogenomics and personalised medicine,... and other contents.

413p muasambanhan05 22-01-2024 3 2   Download

HERPUD1 is an important early marker of endoplasmic reticulum stress (ERS) and is involved in the ubiquitination and degradation of several unfolded proteins. However, its role in tumorigenesis is seldom studied, and its role in ovarian cancer is unclear.

20p vileonardodavinci 23-12-2023 5 2   Download

Despite the advancement in chemotherapeutic drugs for colon cancer treatment, it is still a life-threat‑ ening disease worldwide due to drug resistance. Therefore, an urgently needed to develop novel drugs for colon cancer therapies.

13p vileonardodavinci 23-12-2023 4 3   Download

Triple-negative breast cancer (TNBC) is a lethal mammary carcinoma subtype that affects females and is associated with a worse prognosis. Chemotherapy is the only conventional therapy available for patients with TNBC due to the lack of therapeutic targets.

10p vileonardodavinci 23-12-2023 4 2   Download

Sodium selenite (SSE) has been reported to exert anti-tumor effects in several cancer cells. However, the underlying mechanisms in renal cancer are yet to be elucidated. The effects of SSE on the proliferation, metastasis, and apoptosis of renal cancer cells, as well as its mechanism, were investigated in this study.

14p vialfrednobel 23-12-2023 7 4   Download