Cell surface protein

This volume focuses on the transport of medically relevant bacterial protein toxins into mammalian cells, and on novel pharmacological strategies to inhibit toxin uptake. The first chapters review our current understanding of the cell-surface receptors and cellular transport processes of Clostridium botulinum neurotoxins, Clostridium botulinum C3 toxin, Clostridium difficile toxins, binary clostridial enterotoxins, anthrax toxins and diphtheria toxin.

261p vimeyers 29-05-2024 5 1   Download

Ebook "TNF receptor associated factors (TRAFs)" is the only literature that is entirely devoted to TRAFs. Almost every aspect of TRAF signaling is covered, including the different TRAF family members, their distinct biological functions, the TRAF structures, their modes of receptor recognition, the signaling mechanisms, and the roles of TRAFs in normal cellular functions and in viral infection.

222p ladongphongthanh1008 22-04-2024 1 1   Download

Ebook "Study of the peptide–peptide and peptide–protein interactions and their applications in cell imaging and nanoparticle surface modification" focuses on the study of interactions between protein and peptides and their potential applications in cell imaging and nanoparticle surface modification. Drawing inspiration from naturally occurring coiled-coil binding pairs, it proposes a novel covalent peptide tag and probe system, based on the concept of “affinity guided covalent conjugation.

103p tracanhphuonghoa1007 22-04-2024 3 3   Download

Ebook "Electrochemical analysis of proteins and cells" presents the remarkable progress made over the years in the electrochemical analysis of proteins and cells, due to the rapid development of protein electrochemistry together with related technologies such as surface modification, molecular recognition, molecular assembly, and nanotechnology.

76p coduathanh1122 27-03-2024 6 1   Download

Ebook "Nanobioelectrochemistry: From implantable biosensors to green power generation" describes some of the different electrochemical techniques that can be used to study new strategies for patterning electrode surfaces with enzymes, organelles, cells and biomimetic systems. Also, it focuses on how enzymes and microorganisms can be used as biological catalysts in fuel cells for green power generation.

144p coduathanh1122 27-03-2024 2 1   Download

Ebook "Viral entry into host cells" for a virus to invade a host cell it needs to penetrate the physical barrier imposed by the plasma membrane. Viruses have evolved specialized surface proteins to meet this challenge. These proteins facilitate delivery of the viral genetic information into the host cell by either fusing the viral envelope with a host cell membrane or by forming membrane pores. Membrane fusion and pore formation critically depend on the engagement of host cell receptors and receptor choice is a key determinant of viral tropism.

213p cotieubac1004 15-03-2024 1 0   Download

Part 2 book "Molecular cell biology" includes content: Post transcriptional gene control and nuclear transport, signaling at the cell surface, signaling pathways that control gene activity, integration of signals and gene controls, moving proteins into membranes and organelles, vesicular traffic, secretion and endocytosis, metabolism and movement of lipids, microfilaments and intermediate filaments, microtubules, regulating the eukaryotic cell cycle, cell birth, lineage and death, cancer.

477p muasambanhan07 18-02-2024 5 1   Download

Part 1 book "Gram-Positive pathogens" includes content: The gram positive cell wall, surface proteins on gram positive bacteria, capsular polysaccharide of group a streptococc, toxins and superantigens of group a streptococci, toxins and superantigens of group a streptococci, genetics of group a streptococci, extracellular matrix interactions with gram positive pathogens,... and other contents.

506p muasambanhan05 22-01-2024 5 2   Download

Part 2 book "Gram-Positive pathogens" includes content: Staphylococcal plasmids, transposable and integrative elements; temperate phages of staphylococcus aureus; pathogenicity islands and their role in staphylococcal biology; respiration and small colony variants of staphylococcus aureus; the staphylococcal cell wall; staphylococcal protein secretion and envelope assembly; surface proteins of staphylococcus aureus, immune evasion by staphylococcus aureus,... and other contents.

390p muasambanhan05 22-01-2024 5 2   Download

In tissue engineering, coating biomaterial’s surface with extracellular matrix (ECM) proteins can promote many biological activities, including cellular responses, wound healing, and rejection reduction. Several interactions occur upon binding proteins onto the surfaces, leading to changes in the protein structural conformation, directly affecting the cell-host interactions. Therefore, this study investigates the impacts of surfaces’ wettability on protein conformation.

10p vimulcahy 18-09-2023 6 3   Download

The cell surface and extracellular matrix polysaccharide, heparan sulfate (HS) conveys chemical information to control crucial biological processes. HS chains are synthesized in a non-template driven process mainly in the Golgi apparatus, involving a large number of enzymes capable of subtly modifying its substitution pattern, hence, its interactions and biological effects.

10p viginny 30-12-2022 7 2   Download

Despite rapid developments in single cell sequencing, sample-specific batch effects, detection of cell multiplets, and experimental costs remain outstanding challenges. Here, we introduce Cell Hashing, where oligo-tagged antibodies against ubiquitously expressed surface proteins uniquely label cells from distinct samples, which can be subsequently pooled.

12p vigalileogalilei 27-02-2022 14 1   Download

Extracellular interactions between cell surface receptors are necessary for signaling and adhesion but identifying them remains technically challenging. We describe a cell-based genome-wide approach employing CRISPR activation to identify receptors for a defined ligand. We show receptors for high-affinity antibodies and low-affinity ligands can be unambiguously identified when used in pools or as individual binding probes.

16p vigalileogalilei 27-02-2022 16 1   Download

While we are taught to never judge a book by its cover, covers may actually be revealing. In the case of a cell, the surface proteins on its “cover” are unique to particular cell types: for example, CD3 for T cells and CD19 for B cells. With such markers in hand, populations of cells can be classified into the cell types they contain, in particular using fluorescence-activated cell sorting (FACS) analysis with a panel of antibodies.

3p vialfrednobel 29-01-2022 14 0   Download

Compared to proteins, glycans, and lipids, much less is known about RNAs on the cell surface. We develop a series of technologies to test for any nuclearencoded RNAs that are stably attached to the cell surface and exposed to the extracellular space, hereafter called membrane-associated extracellular RNAs (maxRNAs).

23p viarchimedes 26-01-2022 13 0   Download

The immune system recognizes and destroys cancer cells. However, cancer cells develop mecha‑ nisms to avoid detection by expressing cell surface proteins. Specific tumour cell surface proteins (e.g. HLA-G, PD-L1, CDX2) either alone or in combination with the relative presence of immune cells (CD3 and CD8 positive T-cells) in the tumour tissue may describe the cancer cells’ ability to escape eradication by the immune system.

19p vielonmusk 21-01-2022 12 1   Download

Extracellular matrix metalloproteinase inducer (EMMPRIN), a cell-surface glycoprotein, is overexpressed in several cancer types. EMMPRIN induces a metastatic phenotype by triggering the production of matrix metalloproteinase proteins (MMPs) such as MMP1 and MMP2, and vascular endothelial growth factor (VEGF) in cancer cells and the surrounding stromal cells.

12p vimahuateng 26-11-2021 8 1   Download

Glioblastoma multiforme (GBM) is a highly lethal, stage IV brain tumour with a prevalence of approximately 2 per 10,000 people globally. The cell surface proteins or surfaceome serve as information gateway in many oncogenic signalling pathways and are important in modulating cancer phenotypes.

13p vimahuateng 26-11-2021 21 1   Download

CD40 is an important tumor necrosis factor receptor (TNFR) family protein for the development of antitumor response against cancer cells, apart from its role in the regulation of the immune system as a costimulatory molecule. It is broadly expressed on the surface of immune cells and in diverse cancer types, including breast cancer. Here, we analyzed both CD40/CD40 ligand expression in breast cancer cells and tissues using public data sets and overall survival analysis in ungrouped breast cancer patients, as well as in the triple-negative breast cancer subtype.

9p thiencuuchu 27-11-2021 13 1   Download

G-protein coupled receptors (GPCRs) are ancient, ubiquitous, constitute the largest family of transducing cell surface proteins, and are integral to cell communication via an array of ligands/neuropeptides.

20p vigiselle2711 30-08-2021 10 1   Download