![](images/graphics/blank.gif)
Cellular aging
-
Clear cell renal cell carcinoma (ccRCC) is the prevailing histological subtype of renal cell carcinoma and has unique metabolic reprogramming during its occurrence and development. Cell senescence is one of the newly identified tumor characteristics. However, there is a dearth of methodical and all-encompassing investigations regarding the correlation between the broad-ranging alterations in metabolic processes associated with aging and ccRCC.
23p
vishanshan
27-06-2024
2
1
Download
-
Large numbers of autosomal sites are found differentially methylated in the aging genome. Due to analytical difficulties in dealing with sex differences in X-chromosome content and X-inactivation (XCI) in females, this has not been explored for the X chromosome.
13p
vibransone
28-03-2024
1
1
Download
-
Ebook "Protein metabolism and homeostasis in aging (Advances in experimental medicine and biology, Volume 694)" provided of the current knowledge in the area, including protein synthesis, accuracy and repair, post-translational modifications, degradation and turnover, and how they define and influence aging. The chapters mainly focus on well-characterised factors and pathways, but new areas are also presented, where associations with aging are just being elucidated by current experimental data.
268p
duongthandue0501
28-02-2024
1
1
Download
-
Age and obesity are dominant risk factors for several common cardiometabolic disorders, and both are known to impair adipose tissue function. However, the underlying cellular and genetic factors linking aging and obesity on adipose tissue function have remained elusive.
24p
vicwell
29-02-2024
4
2
Download
-
Part 1 book "Brocklehurst’s textbook of geriatric medicine and gerontology" includes content: Introduction, the epidemiology of aging, the future of old age, successful aging, evolution theory and the mechanisms of aging, methodologic challenges of research in older people, geroscience, genetic mechanisms of aging, cellular mechanisms of aging, the premature aging syndrome, the neurobiology of aging - free radical stress and metabolic pathways, allostasis and allostatic overload in the context of aging, neuroendocrinology of aging,... and other contents.
365p
muasambanhan08
23-02-2024
5
1
Download
-
Part 2 book "Animal models and human reproduction" includes content: The mare as an animal model for reproductive aging in the woman, spotlight on reproduction in domestic dogs as a model for human reproduction, animal models of inflammation during pregnancy, prezygotic chromosomal examination of mouse spermatozoa, molecular and cellular aspects of mammalian sperm acrosomal exocytosis,... and other contents.
350p
muasambanhan04
07-01-2024
4
2
Download
-
Little is known about the role of amino acids in cellular signaling pathways, especially as it pertains to pathways that regulate the rate of aging. However, it has been shown that methionine or tryptophan restriction extends lifespan in higher eukaryotes and increased proline or tryptophan levels increase longevity in C. elegans.
24p
vinarcissa
21-03-2023
2
1
Download
-
In the present study, the physiological changes in aged cress seeds and seeds imbibed under different temperatures after aging were examined. In this regard, an array of analysis concerned with the cell membrane leakages and seed viability was performed. For comparison, accelerated aged seed lots with high, intermediate and low viability were used, in relation to the control (not subjected to short-term imbibitions).
13p
lyhuyenthu
31-01-2023
5
2
Download
-
Resilience refers to the process in which people function well despite adversity. Persistent severe pain may be considered an adversity in people with lower limb osteoarthritis (LLOA). The objectives of this study are: (1) to identify what proportion of older adults with LLOA and persistent severe pain show good functioning; and (2) to explore predictors of resilience.
9p
vinobelprisen
26-03-2022
13
4
Download
-
Almost all elderly dogs develop myxomatous mitral valve disease by the end of their life, but the cavalier King Charles spaniel (CKCS) has a heightened susceptibility, frequently resulting in death at a young age and suggesting that there is a genetic component to the condition in this breed.
14p
vigandhi
23-02-2022
7
1
Download
-
Molecular and cellular changes are intrinsic to aging and age-related diseases. Prior cross-sectional studies have investigated the combined effects of age and genetics on gene expression and alternative splicing; however, there has been no long-term, longitudinal characterization of these molecular changes, especially in older age.
16p
vielonmusk
30-01-2022
11
0
Download
-
Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases. Many genes play a role in cellular senescence, yet a comprehensive understanding of its pathways is still lacking.
22p
viarchimedes
26-01-2022
9
1
Download
-
Autophagy and DNA repair are two essential biological mechanisms that maintain cellular homeostasis. Impairment of these mechanisms was associated with several pathologies such as premature aging, neurodegenerative diseases, and cancer. Intrinsic or extrinsic stress stimuli (e.g., reactive oxygen species or ionizing radiation) cause DNA damage. As a biological stress response, autophagy is activated following insults that threaten DNA integrity.
18p
thiencuuchu
27-11-2021
8
1
Download
-
Aging is accompanied with loss of tissue homeostasis and accumulation of cellular damages. As one of the important metabolic centers, liver shows age-related dysregulation of lipid metabolism, impaired detoxification pathway, increased inflammation and oxidative stress response.
19p
vigiselle2711
30-08-2021
8
1
Download
-
Aging is affected by genetic and environmental factors, and cigarette smoking is strongly associated with accumulation of senescent cells. In this study, we wanted to identify genes that may potentially be beneficial for cell survival in response to cigarette smoke and thereby may contribute to development of cellular senescence.
12p
vigiselle2711
30-08-2021
6
1
Download
-
Diverse stresses including genotoxic therapy can induce proliferating cancer cells to undergo cellular senescence and take on the characteristic phenotypes of replicative cellular aging. This accelerated or therapyinduced senescence has been alternatively proposed to contribute to therapeutic efficacy or resistance.
12p
visilicon2711
20-08-2021
9
1
Download
-
Autophagy, meaning ‘self-eating’, is required for the degradation and recycling of cytoplasmic constituents under stressful and non-stressful conditions, which helps to maintain cellular homeostasis and delay aging and longevity in eukaryotes.
18p
vilichoo2711
23-06-2021
11
1
Download
-
Temperature affects virtually all cellular processes. A quick increase in temperature challenges the cells to undergo a heat shock response to maintain cellular homeostasis. Heat shock factor-1 (HSF-1) functions as a major player in this response as it activates the transcription of genes coding for molecular chaperones (also called heat shock proteins) that maintain structural integrity of proteins.
12p
vimariana2711
22-12-2020
8
0
Download
-
Autophagy is a conserved molecular pathway involved in the degradation and recycling of cellular components. It is active either as response to starvation or molecular damage. Evidence is emerging that autophagy plays a key role in the degradation of damaged cellular components and thereby affects aging and lifespan control.
15p
vioklahoma2711
19-11-2020
13
1
Download
-
Aging is characterized by a gradual breakdown of cellular structures. Nuclear abnormality is a hallmark of progeria in human. Analysis of age-dependent nuclear morphological changes in Caenorhabditis elegans is of great value to aging research, and this calls for an automatic image processing method that is suitable for both normal and abnormal structures.
13p
viflorida2711
30-10-2020
13
2
Download
CHỦ ĐỀ BẠN MUỐN TÌM
![](images/graphics/blank.gif)