Cellular injury

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  • Three distinct sequential cellular responses characterise the reaction of the adult spinal cord and brain to injury. An acute haemorrhagic phase immediately ensues after wounding, in which haematogenous cells flood the lesion site. This is followed by a subacute period during which macrophages clear necrotic debris, glial cell reactions are mobilised, the clot becomes organised, and scarring is initiated. Finally, the scar tissue contracts during a consolidation phase .

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  • I am grateful to the publishers for the invitation to produce a second edition of Applied Basic Science for Basic Surgical Training. Despite the considerable changes to education and examination, the requirement of any future surgeon to possess a comprehensive knowledge of the applied basic sciences remains the core of surgical training; a fact that is universally acknowledged by the organisations most closely involved in the shaping of the surgical curriculum.

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  • Effective new treatments of heart disease are based on a refined understanding of cellular function and the heart's response to environmental stresses. Not surprisingly therefore, the field of experimental cardiology has experienced a phase of rapid exponential growth during the last decade. The acquisition of new knowledge has been so fast that textbooks of cardiology or textbooks of cardiovascular physiology are often hard-pressed to keep up with the most important conceptual advances.

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  • Following their lipophilicity, it is more plausible that vitamin E and ß-carotene cooperate to protect membranes and lipoproteins from oxidative damages. Of course, as all antioxidants, vitamin E exerts other biological functions that are independent from its antioxidant properties, including modulation of cellular signaling, gene expression, immune response, and many more. However, as opposed to other vitamins, lack of vitamin E results in rather unspecific symptoms, also highlighting that this vitamin is mainly needed for its antioxidant activity in vivo.

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  • The currently available treatment options for glomerular disorders are not optimal since most of them either respond only partially or poorly so that relapse and progression is often the rule. Inadequate understanding of the factors underlying the development and progression of glomerular injury in various clinical scenarios is primarily responsible for lack of ideal therapies. The section on immune system and glomerulonephritis has three chapters which basically cover some of the actively investigated areas. Tetsuhiro Tanaka et al.

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  • (BQ) Part 1 book "Textbook of pathology" presentation of content: Introduction to pathology, cell injury and cellular adaptations, techniques for the study of pathology, inflammation and healing, infectious and parasitic diseases, disorders of leucocytes and lymphoreticular tissues, basic diagnostic cytology,... and other contents.

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  • All Americans have a stake in effective response to hate crimes. These crimes demand priority attention because of their special impact. Bias crimes are designed to intimidate the victim and members of the victim’s community, leaving them feeling isolated, vulnerable, and unprotected by the law. Failure to address this unique type of crime could cause an isolated incident to explode into widespread community tension. The damage done by hate crimes, therefore, cannot be measured solely in terms of physical injury or dollars and cents.

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  • (BQ) Part 1 book "BRS pathology" presentation of content: Cellular reaction to injury, inflammation, hemodynamic dysfunction, hemodynamic dysfunction, immune dysfunction, neoplasia, environmental pathology, nutritional disorders, the heart, hemorrhagic disorders,... And other content.

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  • Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care cung cấp cho các bạn kiến thức về ngành y đề tài: Cellular infiltrates and injury evaluation in a rat model of warm pulmonary ischemia–reperfusion...

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  • One of the least recognized causes of cellular damage duringex vivopreser-vation of red blood cells is oxidative injury to the hemoglobin. The latter has been associated with hemolysis through the release of toxic substances and oxidation of vital cell components.

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  • Oxidant-induced cell damage may be initiated by peroxidative injury to lysosomal membranes, catalyzed by intralysosomal low mass iron that appears to comprise a major part of cellular redox-active iron. Resulting relocation of lytic enzymes and low mass iron would result in secondary harm to various cellular constituents.

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  • During the last decades, numerous studies about stem cells and regenerative medicine highlighted new therapeutic approaches to treat several neurological disorders. It is noteworthy that the current optimism over potential stem cell therapies is driven by new understandings of stem cell biology leading to specific cell fate decision.

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  • Plain x-ray plays a limited role in the evaluation of blunt abdominal trauma. Abdominal radiographs are usually unnecessary. X-rays of the chest and pelvis are often obtained to evaluate for concurrent thoracic or pelvic injuries. Abnormal chest x-ray findings of pneumothorax and rib fractures are associated with intraabdominal injuries and are indications for abdominal imaging if a mechanism for multisystem trauma is present. Common findings include free abdominal air (pneumoperitoneum), pneumothorax, and hemothorax.

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  • (BQ) Part 1 book "BRS Pathology" presents the following contents: Cellular reaction to injury, inflammation, hemodynamic dysfunction, genetic disorders, immune dysfunction, neoplasia, environmental pathology, nutritional disorders, vascular system, the heart, anemia, neoplastic and proliferative disorders of the hematopoietic and lymphoid systems.

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  • The third challenge is to develop health strategies that respond to the diverse and evolving needs of countries. This means designing cost-effective strategies which address those diseases and conditions which account for the greatest share of the burden of disease, now and in the future. In addition to the priorities reflected in the MDGs, reproductive health interventions will be essential in all countries. Efforts to reduce violence and injuries - as well as noncommunicable diseases such as those related to cardiovascular disease and tobacco use - are important almost everywhere.

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  • Harrison's Internal Medicine Chapter 45. Azotemia and Urinary Abnormalities Azotemia and Urinary Abnormalities: Introduction Normal kidney functions occur through numerous cellular processes to maintain body homeostasis. Disturbances in any of these functions can lead to a constellation of abnormalities that may be detrimental to survival.

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  • Studies in the past quarter of century have established a role for lymphocytes in the pathogenesis of immune-mediated glomerular diseases. CD4- expressing T helper cells are a subgroup of T lymphocytes that provide help for immunoglobulin production and direct cellular immune mechanisms through activation of effector cells, such as macrophages. The role of T helper cells is variable depending on the nature of disease, and differential activation of T helper cell subsets has been proposed as one of the plausible explanations for the diversity of injury in glomerular diseases....

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  • Chapter 045. Azotemia and Urinary Abnormalities Normal kidney functions occur through numerous cellular processes to maintain body homeostasis. Disturbances in any of these functions can lead to a constellation of abnormalities that may be detrimental to survival. The clinical manifestations of these disorders will depend upon the pathophysiology of the renal injury and will often be initially identified as a complex of symptoms, abnormal physical findings, and laboratory changes that together make possible the identification of specific syndromes.

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  • Extracellular signal regulated kinases 1 and 2 (ERK1/2) regulate cellular responses to a varietyof extracellular stimuli. In the nervous system, ERK1/2 is critical for neur-onal differentiation, plasticityand mayalso modulate neuronal survival. In this minireview, we present evidence that supports prosurvival activityof ERK1/2 in neurons. Several reports suggest that ERK1/2 mediates neuropro-tective activityof extracellular factors, including neurotro-phins. In addition, ERK1/2 is activated byneuronal injury....

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  • Bile salts are potent detergents and can disrupt cellular membranes, which causes cholestasis and hepatocellular injury. However, the mechanism for the resistance of the canalicular membrane against bile salts is not clear. Phosphatidylethanolamine (PE) is converted to phosphatidylcholine (PC) in the liver by phosphatidylethanolamine N-methyltransferase (PEMT).

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