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Cellular responses
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PANoptosis is a specific type of inflammatory programmed cell death (PCD) modality that can be involved in three key modes of cellular programmed cell death-pyroptosis, apoptosis and necroptosis.
13p
vishanshan
27-06-2024
1
1
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Fibrin plays a prominent role in wound healing. It has a hemostatic effect, induces cellular response to wound damage, and, by forming strands to build a matrix, assists in neovascularization and fibroblast proliferation.
230p
vimeyers
29-05-2024
2
2
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This study summarizes a sample of the managers of the Iraqi cellular communications company with 84 employees. The company is a service organization responsible for providing integrated telecommunications services. As a management system that uses human, technical, material and financial resources, its size and value increase in line with technical progress. The demand for telecommunication services is increasing for several factors, the most important being the only means available to the majority and to the increase in population.
6p
longtimenosee10
26-04-2024
1
1
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Ebook "DNA helicases and DNA motor proteins" is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.
308p
ladongphongthanh1008
22-04-2024
3
2
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Ebook "Innate immunity of plants, animals, and humans" wants to give an overview of our current knowledge about the innate immune system of plants, animals and humans. It not only covers the innate immune mechanisms and responses of so diverse organisms such as plants, Cnidaria, Drosophila, urochordates and zebrafish, but also the major receptor systems in mammalians and humans as well as the central defense mechanisms, antimicrobial peptides and the complement system.
248p
ladongphongthanh1008
22-04-2024
4
2
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Ebook "Heat shock proteins in neural cells" address the role of heat shock proteins and cellular stress responses in the brain, with a major focus on nerve cells and glia, namely oligodendrocytes and astrocytes. Chapter 1 summarizes the classification and functional roles of heat shock proteins which are particularly abundant in brain cells.
123p
tracanhphuonghoa1007
22-04-2024
1
1
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Part 1 book "Pocket companion to Robbins cotran pathologic basis of disease" includes content: Cellular responses to stress and toxic insults; acute and chronic inflammation; tissue renewal, regeneration, and repair; hemodynamic disorders, thromboembolic disease and shock; genetic disorders; diseases of the immunesystem; neoplasia; infectious diseases; environmental and nutritional diseases; diseases of infancy and childhood, blood vessels, the heart, diseases of white blood cells, lymph nodes, spleen and thymus.
353p
muasambanhan10
06-04-2024
5
0
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Recent work has reported that the activation of the p53 pathway in primary cells hampers the efficiency of genome editing by CRISPR/Cas9 via induction of apoptosis or cell cycle arrest. These findings highlight the importance of wholly comprehending cellular responses to programmable nucleases in therapeutically relevant cell types to fulfill the promise of genome editing for therapeutic applications for human diseases.
4p
vibransone
28-03-2024
5
2
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Despite growing numbers of immune checkpoint blockade (ICB) trials with available omics data, it remains challenging to evaluate the robustness of ICB response and immune evasion mechanisms comprehensively. To address these challenges, we integrated large-scale omics data and biomarkers on published ICB trials, nonimmunotherapy tumor profiles.
8p
vibransone
28-03-2024
7
2
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T cells exhibit heterogeneous functional states in the tumor microenvironment. Immune checkpoint inhibitors (ICIs) can reinvigorate only the stem cell-like progenitor exhausted T cells, which suggests that inhibiting the exhaustion progress will improve the efficacy of immunotherapy.
16p
vibransone
28-03-2024
3
2
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Tumor mutational burden (TMB; the quantity of aberrant nucleotide sequences a given tumor may harbor) has been associated with response to immune checkpoint inhibitor therapy and is gaining broad acceptance as a result. However, TMB harbors intrinsic variability across cancer types, and its assessment and interpretation are poorly standardized.
16p
vibransone
28-03-2024
2
2
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The heat shock transcriptional response is essential to effective cellular function under stress. This is a highly heritable trait but the nature and extent of inter-individual variation in heat shock response remains unresolved.
13p
vioraclene
31-03-2024
2
2
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Preclinical studies require models that recapitulate the cellular diversity of human tumors and provide insight into the drug sensitivities of specific cellular populations. The ideal platform would enable rapid screening of cell type-specific drug sensitivities directly in patient tumor tissue and reveal strategies to overcome intratumoral heterogeneity.
15p
vibransone
28-03-2024
3
2
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We present Beyondcell, a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in a collection of drug signatures, delineating therapeutic clusters (TCs) within cellular populations.
15p
vibransone
28-03-2024
2
1
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Recent investigations of the meninges have highlighted the importance of the dura layer in central nervous system immune surveillance beyond a purely structural role. However, our understanding of the meninges largely stems from the use of pre-clinical models rather than human samples.
25p
viellison
28-03-2024
1
1
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Drug resistance continues to be a major limiting factor across diverse anti-cancer therapies. Contributing to the complexity of this challenge is cancer plasticity, in which one cancer subtype switches to another in response to treatment, for example, triple-negative breast cancer (TNBC) to Her2-positive breast cancer
17p
viellison
28-03-2024
3
2
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Single-cell transcriptomics reveals common epithelial response patterns in human acute kidney injury
Acute kidney injury (AKI) occurs frequently in critically ill patients and is associated with adverse out‑ comes. Cellular mechanisms underlying AKI and kidney cell responses to injury remain incompletely understood.
18p
viellison
28-03-2024
3
2
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Medulloblastoma (MB) is a malignant tumour of the cerebellum which can be classifed into four major subgroups based on gene expression and genomic features. Single-cell transcriptome studies have defined the cellular states underlying each MB subgroup; however, the spatial organisation of these diverse cell states and how this impacts response to therapy remains to be determined.
28p
vicwell
29-02-2024
3
1
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Novel immunotherapy combination therapies have improved outcomes for patients with hepatocellular carcinoma (HCC), but responses are limited to a subset of patients. Little is known about the inter- and intra-tumor heterogeneity in cellular signaling networks within the HCC tumor microenvironment (TME) that underlie responses to modern systemic therapy.
14p
vicwell
29-02-2024
6
2
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Ebook "Crossroads between innate and adaptive immunity IV (Advances in experimental medicine and biology, Volume 785)" presents a collection of reviews derived from work presented at the Aegean Conference: “4th Crossroads between innate and adaptive immunity”. This meeting was the fourth in a series, and assembled a team of scientists working on mechanisms by which the innate immune system of the host senses pathogens, the cellular and signaling networks that orchestrate the innate response and antigen presentation and adaptive immunity.
144p
duongthandue0501
28-02-2024
1
1
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