Chemotherapeutic compounds
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Part 2 book "Antiparasitic and antibacterial drug discovery - From molecular targets to drug candidates" includes content: In search of trypanocidal drugs, trypanosomatid protein kinases as potential drug targets, chemotherapeutic development strategies for schistosomiasis, searching new antiparasitics in virtual space, chemical optimization of anthelmintic compounds – a case study,.... and other contents.
255p oursky04 14-09-2023 5 4 Download
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Cancer is a disease characterized by the continuous growth of cells without adherence to the rules that healthy normal cells obey. Carbonic anhydrase I and II (CA I and CA II) inhibitors are used for the treatment of some diseases. The available drugs in the market have limitations or side effects, which bring about the need to develop new drug candidate compound(s) to overcome the problems at issue.
35p tudichquannguyet 29-11-2021 5 1 Download
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Now a day’s world population is facing several health problems caused by bacteria, virus, fungus, protozoan and other micro-organisms which could be due to drug resistant or parasitism and generates an alarming situation to world population for their survival. The requirement for novel and beneficial compounds like antibiotics, chemotherapeutic agents and agrochemicals to offer assistance in several aspects of the human life is ever increasing that are very effective and having negligible or very low toxicity to the environment.
9p trinhthamhodang1215 23-09-2020 21 2 Download
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Chemotherapy for soft tissue sarcomas remains unsatisfactory due to their low chemosensitivity. Even the first line chemotherapeutic agent doxorubicin only yields a response rate of 18-29%. The antibiotic salinomycin, a potassium ionophore, has recently been shown to be a potent compound to deplete chemoresistant cells like cancer stem like cells (CSC) in adenocarcinomas.
9p vijennie2711 29-09-2020 8 1 Download
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Cancer cell esterases are often overexpressed and can have chiral specificities different from that of the corresponding normal cells and can, therefore, be useful targets for activating chemotherapeutic prodrug esters. Prodrug esters are inactive compounds that can be preferentially activated by esterase enzymes.
13p vilisa271 22-09-2020 8 1 Download
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The B-subunit of Shiga toxin (STxB) specifically binds to the glycosphingolipid Gb3 that is highly expressed on a number of human tumors and has been shown to target tumor cells in mouse models and ex vivo on primary colon carcinoma specimen.
11p vilisa271 22-09-2020 16 1 Download
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Platinum-based drugs are used as cancer chemotherapeutics for the last 40 years. However, drug resistance and nephrotoxicity are the major limitations of the use of platinum-based compounds in cancer therapy. Platinum (IV) complexes are believed to act as platinum prodrugs and are able to overcome some of platinum (II) limitations.
11p vinaypyidaw2711 26-08-2020 10 1 Download
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In pediatric sarcomas, outcomes of established therapies still remain poor, especially due to highgrade resistances to chemotherapeutic compounds. Taking novel biological approaches into account, virotherapy was found to be efficient in many pediatric sarcoma types.
15p vikuala271 13-06-2020 10 1 Download
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Chalcones are intent in the daily diet as a favorable chemotherapeutic compound; on the other hand thiophene moiety is present in a large number of bioactive molecules having diverse biological effciency.
8p vijiraiya2711 27-05-2020 9 1 Download
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The overzealous and indiscriminate use of most of the synthetic fungicides has created different types of environmental and toxicological problems. Recently, in different parts of the world, attention has been paid towards exploitation of higher plant products as novel chemotherapeutants in plant protection. Pyrethroids, and neem products are well established commercially as botanical pesticides and recently some essential oils of higher plants and animals products have also been used as antimicrobials against diseases.
21p cothumenhmong3 22-02-2020 25 1 Download
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Multidrug resistance (MDR) in tumour cells is often caused by the overexpression of the plasma drug transporter P-glycoprotein (P-gp). This protein is an active efflux pump for chemotherapeutic drugs,natural products and hydro-phobicpeptides.Despite theadvancesof recent years,we still have an unclear view of the molecular mechanismby which P-gp transports such a wide diversity of compounds across themembrane.
10p tumor12 20-04-2013 39 2 Download
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ABCG2 confers resistance to cancer cells by mediating the ATP-dependent outward efflux of chemotherapeutic compounds. Recent studies have indi-cated that the protein contains a number of interconnected drug binding sites. The present investigation examines the coupling of drug binding to ATP hydrolysis.
9p galaxyss3 07-03-2013 41 2 Download
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Most drugs against malaria that are available or under development target a single process of the parasite infective cycle, favouring the appearance of resistant mutants which are easily spread in areas under chemotherapeutic treatments.
11p cosis54 04-01-2013 31 3 Download