Chromosome aberration
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Colibactin, a genotoxin produced by polyketide synthase harboring (pks+) bacteria, induces doublestrand breaks and chromosome aberrations. Consequently, enrichment of pks+Escherichia coli in colorectal cancer and polyposis suggests a possible carcinogenic effect in the large intestine.
7p vikoch 27-06-2024 1 1 Download
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Enabled by high-throughput sequencing approaches, epithelial cancers across a range of tissue types are seen to harbor gene fusions as integral to their landscape of somatic aberrations. Although many gene fusions are found at high frequency in several rare solid cancers, apart from fusions involving the ETS family of transcription factors which have been seen in approximately 50 % of prostate cancers, several other common solid cancers have been shown to harbor recurrent gene fusions at low frequencies.
18p vioraclene 31-03-2024 3 0 Download
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The genotoxic potential of KOVIR capsules was investigated in vivo using the mammalian bone marrow chromosomal aberration test. The present study aimed to examine the genotoxic potential of the KOVIR capsules using the chromosomal aberration test in laboratory mice.
7p vilarry 12-03-2024 2 1 Download
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Part 1 book "Introduction to veterinary genetics" includes content: Basic genetics, molecular biology, single-gene disorders, chromosomal aberrations, single genes in populations, familial disorders not due to a single gene, is it inherited, immunogenetics.
182p muasambanhan06 03-02-2024 5 1 Download
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Hereditary chromosomal 9 inversion (p22q13) 9 as a cause for recurrent pregnancy loss: A case report
Chromosomal aberrations are as common as 13.8% in the infertile population. The incidence of pericentric inversion of chromosome 9 is approximately 1–3%. However, although these inversions do not alternate phenotype, there have been conflicting data about their effect as they were correlated with infertility, recurrent pregnancy loss, and deceased children, with no clear evidence of the inversions being the causative factor for these events.
8p vitiki 30-01-2024 7 2 Download
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Myeloid leukemia (ML) is a cancer of the blood that begins when cells of the myeloid lineage uncontrollably change and grow. Acute myeloid leukemia (AML) is a disorder of rapid, uncontrolled growth of immature myeloid cells in the blood and bone marrow. Chronic myeloid leukemia (CML) is characterized by the aberrant proliferation of myeloid cells and driven by the translocation of regions of the BCR and ABL genes to form the Philadelphia (Ph) chromosome.
8p vimulcahy 18-09-2023 6 3 Download
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Triploid organisms have three sets of chromosomes. In Atlantic salmon, hydrostatic pressure treatment of newly fertilized eggs has been extensively used to produce triploids which are functionally sterile due to their unpaired chromosomes. These fish often perform poorly on commercial farms, sometimes without explanation. Inheritance patterns in individuals subjected to pressure treatment have not been investigated in Atlantic salmon thus far.
11p vihagrid 30-01-2023 12 3 Download
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Somatic evolution of malignant cells produces tumors composed of multiple clonal populations, distinguished in part by rearrangements and copy number changes affecting chromosomal segments. Whole genome sequencing mixes the signals of sampled populations, diluting the signals of clone-specific aberrations, and complicating estimation of clone-specific genotypes.
14p vialfrednobel 29-01-2022 12 0 Download
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The root growth initiation was concentration and/or time dependent. The applied concentrations of BA showed a promotor effect on cell division in root tips of both plants and caused an increase in their mitotic index values (MI).
11p schindler 30-12-2021 9 1 Download
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Neoplastic transformation of germinal center B (GCB) cells may give rise to a variety of different B cell lymphoma subtypes, most of which show substantial heterogeneity in terms of genetic alterations and clinical features. The mutations observed in cancerrelated genes in GCB cells are related to abnormalities in the immunogenetic mechanisms associated with germinal center reaction. Recent studies have rapidly identified genomic alterations in B cell lymphomas that may be useful for better subclassification, noninvasive diagnosis, and prediction of response to therapy.
14p thiencuuchu 27-11-2021 13 1 Download
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Accumulating evidence suggests that genome plasticity allows filamentous plant pathogens to adapt to changing environments. Recently, the generalist plant pathogen Phytophthora ramorum has been documented to undergo irreversible phenotypic alterations accompanied by chromosomal aberrations when infecting trunks of mature oak trees (genus Quercus). In contrast, genomes and phenotypes of the pathogen derived from the foliage of California bay (Umbellularia californica) are usually stable.
19p vibeauty 23-10-2021 12 1 Download
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Balanced complex chromosome rearrangements (BCCR) are balanced chromosomal structural aberrations that involve two or more chromosomes and at least three breakpoints. It is very rare in the population. The objective is to explore the difference of influence of three types of BCCR on early embryonic development and molecular karyotype.
7p vijeeni2711 24-07-2021 6 0 Download
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The potential genotoxicity of cola- containing soft drink was investigated by Vicia faba assay. Root tips were treated with different concentrations of the cola- containing soft drink (100% and 50%) at 24 hours exposure. The concentration exposure affected the mitotic division in root tip cells and produced various chromosomal aberrations. The abnormalities scored were, bridges, fragments, lobulated nuclei, sticky metaphase and sticky anaphase. Exposure to soft drinks inhibited the cell cycle in a concentration dependent manner.
5p trinhthamhodang11 27-04-2021 6 1 Download
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Detection of DNA copy number alterations (CNAs) is critical to understand genetic diversity, genome evolution and pathological conditions such as cancer. Cancer genomes are plagued with widespread multi-level structural aberrations of chromosomes that pose challenges to discover CNAs of different length scales, and distinct biological origins and functions.
22p vicolorado2711 22-10-2020 8 0 Download
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Ewing’s sarcoma is a malignancy characterized by a specific 11:22 chromosomal translocation which generates a novel EWS-FLI1 fusion protein functioning as an aberrant transcription factor. In the present study, we have further characterized the junction region of the EWS-FLI1 fusion protein.
10p vijisoo2711 30-09-2020 8 2 Download
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Genetic aberrations are required for the progression of HPV-induced cervical precancers. A prerequisite for clonal expansion of cancer cells is unlimited proliferative capacity. In a cell culture model for cervical carcinogenesis loss of genes located on chromosome 4q35→qter and chromosome 10p14-p15 were found to be associated with escape from senescence.
11p vijennie2711 29-09-2020 11 2 Download
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Aggressive neuroblastoma remains a significant cause of childhood cancer death despite current intensive multimodal treatment protocols. The purpose of the present work was to characterize the genetic and clinical diversity of such tumors by high resolution arrayCGH profiling.
14p vijennie2711 29-09-2020 8 0 Download
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It is known that all tumors studied in sufficient number to draw conclusions show characteristic/ specific chromosomal rearrangements, and the identification of these chromosomes and the genes rearranged behind the aberrations may ultimately lead to a tailor-made therapy for each cancer patient.
7p virose2711 24-09-2020 15 0 Download
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B-cell precursor acute lymphoblastic leukemia (B-ALL) is amongst the leading causes of childhood cancer-related mortality. Its most common chromosomal aberration is the ETV6-RUNX1 fusion gene, with ~25 % of ETV6-RUNX1 patients also carrying PAX5 alterations.
6p viamsterdam 18-09-2020 14 1 Download
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Animal model experiments have suggested a role of the DNA repair protein ERCC1 (Excision Repair Cross-Complementation Group 1) in prostate cancer progression.
11p vidhaka2711 31-07-2020 15 2 Download