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Coding DNA sequences
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Immunotherapy based on checkpoint inhibitors is highly effective in mismatch repair deficient (MMRd) colorectal cancer (CRC). These tumors carry a high number of mutations, which are predicted to translate into a wide array of neoepitopes; however, a systematic classifcation of the neoantigen repertoire in MMRd CRC is lacking.
17p
vicwell
29-02-2024
4
1
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Bài viết Xác định, thiết kế mồi nhận biết Candidate gen kháng rầy nâu BPH14 ở một số giống lúa địa phương của Việt Nam và ứng dụng trong lai tạo giống trình bày kết quả tầm soát, phân tích thành phần nucleotide vùng CDS (Coding DNA Sequence) và thành phần amino acid của các candidate gen Bph14; Thiết kế mồi nhận dạng candidate gen Bph14 kháng rầy nâu; Kết quả bước đầu nghiên cứu khả năng kháng rầy của các candidate gen Bph14.
7p
vithor
20-07-2023
5
1
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Bài viết Thiết kế marker chức năng nhằm xác định Candidate gen kháng bạc lá (xả) ở một số giống lúa địa phương của Việt Nam trình bày kết quả tầm soát, phân tích thành phần nucleotide vùng CDS (Coding DNA Sequence) và thành phần amino acid của candidate gen xa13; Thiết kế marker xác định candidate gen kháng bạc lá xa13.
6p
vithor
20-07-2023
3
1
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In a previous study, a gene GL0694641 coding for endoglucanase containing 3 domains GH5- CBM72-CBM72 was exploited from metagenomic DNA data of bacteria in Vietnamese goats’ rumen. The gene (eg5) encoding the mature enzyme (without signal peptide coding sequence) was optimized codons, artificially synthesized, and inserted into the pET22b(+) vector at NcoI and XhoI to generate expression vector pET22-eg5 for expression of the gene in Eschrichia coli.
11p
vicaptainmarvel
21-04-2023
5
2
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Cytoplasmic male sterility (CMS) is a maternally inherited inability to produce functional pollen found in numerous flowering plant species. CMS is associated with mitochondrial DNA mutation, novel chimeric open reading frames (ORFs), and rearrangement of coding and noncoding regions of the mitochondrial genome.
10p
vinarcissa
21-03-2023
2
1
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Microsatellites or simple sequence repeats (SSRs) are DNA sequences consisting of 1–6 bp tandem repeat motifs present in the genome. SSRs are considered to be one of the most powerful tools in genetic studies.
9p
vinarcissa
21-03-2023
2
1
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Cellobiohydrolase (EC 3.2.1.91) is one of the important enzymes involved in cellulose hydrolysis. In this study, the gene sequences encoding cellobiohydrolase were extracted from the metagenome DNA data of microorganisms surrounding white-rot fungi in Cuc Phuong National Park based on the KEGG database. 73 ORFs encoding cellobiohydrolase were obtained, of which 15 ORFs contained complete genes, 6 ORFs with functional regions.
8p
vineville
08-02-2023
5
1
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POLG, located on nuclear chromosome 15, encodes the DNA polymerase γ(Pol γ). Pol γ is responsible for the replication and repair of mitochondrial DNA (mtDNA). Pol γ is the only DNA polymerase found in mitochondria for most animal cells. Mutations in POLG are the most common single-gene cause of diseases of mitochondria and have been mapped over the coding region of the POLG ORF.
16p
vihagrid
30-01-2023
5
3
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DNA barcoding is a short DNA fragment, is used to distinguish between species, especially morphologically similar species and processed specimens that are difficult to distinguish species. For plants, the regions of DNA used as barcodes in identification or taxonomy are usually sequences of the chloroplast genome and the nuclear genome, including the coding regions and the non-coding regions.
9p
vilamborghini
12-10-2022
8
4
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The functional impact of genetic variation has been extensively surveyed, revealing that genetic changes correlated to phenotypes lie mostly in non-coding genomic regions. Studies have linked allele-specific genetic changes to gene expression, DNA methylation, and histone marks but these investigations have only been carried out in a limited set of samples.
21p
vialfrednobel
29-01-2022
10
0
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Patterns of genetic and genomic variance are informative in inferring population history for human, model species and endangered populations. Results: Here the genome sequence of wild-born African cheetahs reveals extreme genomic depletion in SNV incidence, SNV density, SNVs of coding genes, MHC class I and II genes, and mitochondrial DNA SNVs.
20p
viaristotle
29-01-2022
10
0
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Sequences of the mitochondrial cytochrome oxidase I (COI) gene of one Greek and 25 Turkish Myzus cerasi (Fabricus) (Hemiptera: Aphididae) populations collected from Prunus avium and Prunus cerasus were analyzed. The partial coding region of COI studied is 605 bp for all the populations, from which 565 nucleotides were conserved, 40 were variable, 37 were singleton, and 3 were parsimony-informative. Four haplotypes were identified based on nucleotide substitutions and the mean of intraspecific divergence was calculated to be 0.3%.
10p
dolomite36
30-12-2021
19
0
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Lung adenocarcinoma (LUAD) is the most common histological subtype of primary lung cancer. To identify the biomarker of diagnosis for LUAD is of great significance. Long non-coding RNAs (lncRNAs) were previously revealed to exert vital efects in numerous cancers.
12p
vimackenziebezos
29-11-2021
7
1
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In this study we hypothesize that variants in some functional classes, such as splice site regions, coding regions, DNA methylated regions and long noncoding RNA will explain more variance in complex traits than others. Two variance component approaches were used to test this hypothesis – the first determines if variants in a functional class capture a greater proportion of the variance, than expected by chance, the second uses the proportion of variance explained when variants in all annotations are fitted simultaneously.
16p
vilarryellison
29-10-2021
11
0
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Temperature adaptation of biological molecules is fundamental in evolutionary studies but remains unsolved. Fishes living in cold water are adapted to low temperatures through adaptive modification of their biological molecules, which enables their functioning in extreme cold. To study nucleotide and amino acid preference in cold-water fishes, we investigated the substitution asymmetry of codons and amino acids in protein-coding DNA sequences between cold-water fishes and tropical fishes.
10p
vibeauty
23-10-2021
8
1
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The splice sites of transcripts were also delineated by distinct signature signals. Relatively higher structural signals were observed at 3’ Untranslated Regions (UTRs) compared to Coding DNA Sequence (CDS) and 5’ UTRs. The 3′ ends of transcripts were also marked by unique structure signals. Secondary structural signals in long non-coding RNAs were also explored to better understand their molecular function.
17p
vibeauty
23-10-2021
13
0
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Long non-coding RNAs (lncRNAs) are involved in variable cleavage, transcriptional interference, regulation of DNA methylation and protein modification. However, the regulation of lncRNAs in plant somatic embryos remains unclear. The longan (Dimocarpus longan) somatic embryogenesis (SE) system is a good system for research on longan embryo development.
19p
vitzuyu2711
29-09-2021
6
1
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Repetitive DNA sequences (Repeats) are significant regions in the human genome that have a specific genomic distribution, structure, and several binding sites for genome architecture and function. In consequence, the possible configurations of Repeats in specific and dynamic regions like the gene promoters could define footprints for molecular mechanisms, pathways, and cell function beyond their density in the genome.
11p
viseulgi2711
31-08-2021
8
1
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Although DNA sequence plays a crucial role in establishing the unique epigenome of a cell type, little is known about the sequence determinants that lead to the unique epigenomes of different cell types produced during cell differentiation.
18p
visilicon2711
20-08-2021
7
1
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Environmental stimuli can activate a series of physiological and biochemical responses in plants accompanied by extensive transcriptional reprogramming. Long non-coding RNAs (lncRNAs), as versatile regulators, control gene expression in multiple ways and participate in the adaptation to biotic and abiotic stresses.
12p
visilicon2711
20-08-2021
11
1
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