Crystal reports 8.5

Single-crystal X-ray structure determinations of the complex between the minor-groove binder distamycin and d(GGCCAATTGG) reveal two 1 : 1 binding modes which differ in the orientation of the drug molecule in the minor groove. The two crystals were grown from different crystallization conditions and found to diffract to 2.38 and ˚ 1.85 A, respectively. The structures were refined to completion using SHELXL-93, resulting in a residual R factor of ˚ 20.30% for the 2.38-A resolution structure (including 46 ˚ water molecules) and 19.74% for the 1.

10p system191 01-06-2013 33 5   Download

The crystal structure of citrate synthase from the thermo-philic ArchaeonSulfolobus solfataricus(optimum growth temperature ¼85
C) has been determined, extending the number of crystal structures of citrate synthase from differ-ent organisms to a total of five that span the temperature range over which life exists (from psychrophile to hyper-thermophile). Detailed structural analysis has revealed possible molecular mechanisms that determine the different stabilities of thefiveproteins.

11p tumor12 22-04-2013 62 3   Download

The structural and kinetic effects of amprenavir (APV), a clinical HIV pro-tease (PR) inhibitor, were analyzed with wild-type enzyme and mutants with single substitutions of V32I, I50V, I54V, I54M, I84V and L90M that are common in drug resistance. Crystal structures of the APV complexes at resolutions of 1.02–1.85 A ˚ reveal the structural changes due to the muta-tions.

16p viettel02 19-02-2013 43 3   Download