Cytotoxic compound

Chemical investigation of the sesame-associated fungal strain Penicillium hetheringtonii IMBC-NMTP04 resulted in isolation of five compounds, penicitrinone A (1), dihydrocitrinin (2), janthinone (3), coniochaetone B (4), and 9-oxo-10(E),12(E)-octadecadienoic acid (5).

8p viambani 18-06-2024 2 1   Download

The present study reported the isolation, elucidation of compounds from the whole plant and their cytotoxic activities on Hep G2 (HB - 8065TM, hepatocellular carcinoma), A549 (CCL-185™, pulmonary adenocarcinoma), and MCF-7 (HTB - 22TM, breast cancer) cell lines. As a result, velutin exhibited the most significant cytotoxicity against Hep G2, A549, and MCF-7 cell lines with IC50 values of 34.00, 30.85, and 41.33 μg/mL, respectively.

4p vicarlos 16-05-2024 1 0   Download

From propolis of Lepidotrigona ventralis stingless bee collected in Tuyen Quang province, eight compounds were isolated and determined as lantanolic acid, moronic acid, (+)-eudesmin, (+)-yangambin, (+)-syringaresinol, (+)-pinoresinol, dihydroconiferyl alcohol and vanillin using NMR and MS spectral data. Compounds 1 and 2 showed significant cytotoxicity against HepG-2 cancer cell line with IC50 values of 25.84±0.48 and 39.92±1.14 ug/mL, respectively.

6p dianmotminh02 03-05-2024 2 1   Download

Phytochemical study of Knema pachycarpa leaves led to the isolation of ten compounds. Their chemical structures were determined as (7''R, 8''R)-hydnocarpin D, (7''R, 8''R)-hydnocarpin, sinaicitin, (-)-globulol, β-caryolanol, phytol, biochanin A, chrysoeriol, tanoside II and astragalin using NMR and MS spectral data. Among the isolates, (7''R, 8''R)-hydnocarpin showed good cytotoxic activity against KB, HepG-2, Lu and MCF-7 cancer cell lines with IC50 values from 13.99±0.62 ug/mL to 30.65±1.44 ug/mL.

6p dianmotminh02 03-05-2024 1 1   Download

In this work, we report the isolation and structure characterization of four compounds from ethyl acetate extract of the aerial part of D. harmandii for the first time. Especially, the absolute configuration of dimer stilbene ampelopsin F was successfully established upon circular dichroism (ECD) data. Besides, the cytotoxic properties of these compounds was also investigated on the cancer cell lines.

6p dianmotminh02 03-05-2024 3 1   Download

Alpinia vietnamica H.Ð. Tran, Luu & Skornick was identified as a new species in 2019, which is widely distributed in Thua Thien Hue, Quang Nam, and Kon Tum provinces, Vietnam. The current study wishes to report phytochemical investigation, and the biological activities (cytotoxic, antioxidative, and α-glucosidase inhibitory) of isolated compounds.

5p dianmotminh02 03-05-2024 8 1   Download

The methanol extracts as well as some compounds from this plant exhibited anti-inflammatory, antimicrobial activity, antioxidant, hepatoprotective and anti-cancer effect, and antiosteoporotic. On going to search for bioactive components from the Vietnamese plant, this paper reported the isolation of seven phenolic compounds including one new from the aerial parts of A. ilicifolius. The cytotoxic activity of the isolates against two cancer cell lines (HepG2 and SK-LU1) were also screened and reported herein.

5p dianmotminh02 03-05-2024 6 1   Download

This compound converted to Mannich base which interne illustrated as tridentate ligand of NO2-type. Meanwhile, the organic synthesis of the compounds is not an easy task, especially lactonization; hint naphthafuran-2-one has never been prepared from amino nitrile previously. Selected metal ions of known anticancer activity interacted with the ligand to present novel complexes to figure out the cytotoxicity effect of both organic and inorganic parts against cancer cell line.

10p dianmotminh02 03-05-2024 2 1   Download

The synthesized compounds' enzyme inhibition potential was tested against a-glucosidase, AChE, and BChE enzymes. As illustrated from the results of IC50, these compounds are observed as the active inhibitory potential for these enzymes. The cytotoxic activity by hemolytic Assay revealed that these compounds have mild exposure to cytotoxicity on RBCs.

10p visergey 02-04-2024 0 0   Download

Ebook "Handbook of anticancer drugs from marine origin" also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

801p tudohanhtau1006 29-03-2024 3 1   Download

This study was conducted to determine the solvent and additives to obtain high bioactive compounds from Daklak Vietnam Robusta GCB to evaluate extraction methods, the properties (emulsion formation, particle, stability) and testing the antioxidant, antibiotic and cytotoxicity of the nanoemulsions of Robusta GCB extract.

7p viellison 28-03-2024 3 1   Download

Ebook "Natural compounds as inducers of cell death: Volume 1" gives a multi-disciplinary approach into the anti-cancer research field related to natural products and dietary compounds. Mainly, it covers the area of antitumor activity through an in-depth description of the cytotoxic, anti-inflammatory and anti-oxidant properties in cancer, inflammatory and cardio-vascular diseases.

512p manmanthanhla0201 26-02-2024 5 1   Download

Liver cancer and breast cancer have high death rates and tend to increase rapidly in recent years in Vietnam and over the world. Currently, the study of bioactive compounds isolated from plants for killing cancer cells is of interest. The study aims to identify the cytotoxicity using MTT assay of Combretum quadrangulare Kurz fractions against MCF-7 cells.

10p vibego 02-02-2024 1 0   Download

In the last few decades, pyrazoline-based substances have emerged as potential antimicrobial and anticancer candidates. In concern with antimicrobial activity, this study aims to build a docking model to predict the structure of potential 2-pyrazoline derivatives. The cytotoxicity of some compounds was also evaluated to get insight into the structure–anticancer activity relationship of the 2- pyrazoline derivatives.

8p vikissinger 21-12-2023 3 2   Download

As a continuation of our work on the bioactive constituents from Caesalpinia species, eight compounds (1−8) were isolated from the air-dried leaves of C. bonduc, collected from Vinh Phuc province of Vietnam. The cytotoxic activity of eight compounds (1–8) was screened on HepG2 human cancerous cells using the sulforhodamine B colorimetric assay.

8p viberkshire 09-08-2023 5 4   Download

In the present study, we report the synthesis and cytotoxic activity of novel 2'-hydroxychalcones containing carbazole murrayafoline A, an anti-cancer compound from Glycosmis sternocapa.

8p viannee 02-08-2023 5 3   Download

Knema (Myristicaceae family) is a large genus, comprising over 100 species found in of South East Asian countries, among that over 10 species was found in Vietnam. Knema pachycarpa is a native tree distributed in central provinces of Viet Nam. Until now, only few chemical studies of Knema species in Viet Nam have been reported.

8p viannee 02-08-2023 6 3   Download

Plants of the genus Polyscias (the family Araliaceae) are represented as perennial shrubs and are commonly cultivated in southeastern Asia and the Pacific regions. Pharmacological studies revealed that Polyscias crude extracts and their isolated compounds exhibited a variety of biological activity, such as antibacterial, antifungal, cytotoxic, immunostimulant, wound healing and anti-asthmatic activities.

8p viannee 02-08-2023 5 3   Download

Macrosolen tricolor (Lec.) Dans. is a traditional medicinal plant and belongs to the family Loranthaceae, which is distributed in Nha Trang, and Phan Rang. This paper describes the isolation, structural elucidation, and cytotoxic activity of compounds from the ethyl acetate extract of the whole plant of M. tricolor (Lec.) Dans.

5p vidoctorstrange 06-05-2023 4 2   Download

In the context of sources for natural products discovery are going scarcer, exploiting biotechnologically potential compounds from marine microbial symbionts is considered a relatively new trend. In our study a total of fifteen fungal strains were isolated from marine algal samples belonging to species Kappaphycus cottonii, K. striatus, Gracilaria eucheumatoides and Betaphycus gelatinus collected in Nha Trang in 2017.

7p vicaptainmarvel 21-04-2023 5 3   Download