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Deacetylate histone
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This study aimed to examine the effect of HDACi treatment during the ZGA period. In this study, the effect of HDACi treatment with different concentrations on preimplantation development of cloned bovine embryos is done.
7p
vimalfoy
08-02-2023
6
1
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Epigenetic modifications including DNA methylation and post-translational modifications of histones are known to regulate gene expression. Antagonistic activities of histone acetyltransferases (HATs) and histone deacetylases (HDACs) mediate transcriptional reprogramming during insect development as shown in Drosophila melanogaster and other insects.
15p
viseulgi2711
31-08-2021
11
1
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Histone deacetylases (HDACs) catalyze histone deacetylation and suppress gene transcription during various cellular processes. Within the superfamily of HDACs, RPD3/HDA1-type HDACs are the most studied, and it is reported that RPD3 genes play crucial roles in plant growth and physiological processes. However, there is a lack of systematic research on the RPD3/HDA1 gene family in cotton.
16p
vijeeni2711
30-06-2021
7
1
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Histone acetylation and deacetylation play an important role in the regulation of gene expression, influencing the transcription of many genes. Deregulation of histone results in abnormal gene expression profiles involved in controlling cell proliferation, differentiation and apoptosis of cancer cells, and is associated with malignancy,
8p
viwyoming2711
15-12-2020
11
1
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Tumor expression of estrogen receptor (ER) is an important marker of prognosis, and is predictive of response to endocrine therapy in breast cancer. Several studies have observed that epigenetic events, such methylation of cytosines and deacetylation of histones, are involved in the complex mechanisms that regulate promoter transcription.
8p
virose2711
25-09-2020
14
0
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SIRT1 is a member of the mammalian sirtuin family with the ability to deacetylate histone and nonhistone proteins. The correlation between SIRT1 expression and tumor metastasis in several types of cancer has aroused widespread concern.
10p
vialabama2711
21-09-2020
6
1
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The Sir2 family of histone⁄protein deacetylases (sirtuins) is comprised of homologues found across all kingdoms of life. These enzymes catalyse a unique reaction in which NAD + and acetylated substrate are converted into deacetylated product, nicotinamide, and a novel metabolite O-acetyl ADP-ribose. Although the catalytic mechanism is well conserved across Sir2 family members, sirtuins display differential specificity toward acetyl-ated substrates, which translates into an expanding range of physiological functions. ...
10p
fptmusic
11-04-2013
39
1
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The third part of the book is dedicated to analysis of role of DNA methylation in cancer. According to the American Cancer Association, nearly 13% of all deaths worldwide are cancer related. Aberrant DNA methylation patterns is likely to play a causative role in cancer initiation and development. The first chapter is dedicated to investigation of DNA methylation role in the development of hepatocellular carcinoma associated with tyrosinemia.
234p
yeutinh98
22-09-2012
57
10
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Inhibition of histone deacetylation in 293GPG packaging cell line improves the production of self-inactivating MLV-derived retroviral vectors
12p
dauphong7
13-01-2012
43
2
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