Determining cellular identity
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Transcription factor (TF) binding to regulatory DNA sites is a key determinant of cell identity within multi-cellular organisms and has been studied extensively in relation to site affinity and chromatin modifications. There has been a strong focus on the inference of TF-gene regulatory networks and TF-TF physical interaction networks.
23p vigalileogalilei 27-02-2022 15 1 Download
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DNA methylation plays important roles in determining cellular identity, disease, and environmental responses, but little is known about the mechanisms that drive methylation changes during cellular differentiation and tumorigenesis.
12p vigalileogalilei 27-02-2022 14 1 Download
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Single-cell transcriptomics is rapidly advancing our understanding of the cellular composition of complex tissues and organisms. A major limitation in most analysis pipelines is the reliance on manual annotations to determine cell identities, which are time-consuming and irreproducible
19p vielonmusk 30-01-2022 14 0 Download
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Hair follicles (HFs), upon development, undergo repetitive cycles of growth (anagen), regression (catagen), and rest (telogen). The transition between the stages is determined by multiple molecular signals, including DNA methylation, which plays important roles in mammalian cellular identity and is essential for the development of HFs.
9p vitzuyu2711 29-09-2021 15 2 Download
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The HOX genes are a family of homeodomain-containing transcription factors that determine cellular identity during development and which are dys-regulated in some cancers. In this study we examined the expression and oncogenic function of HOX genes in mesothelioma, a cancer arising from the pleura or peritoneum which is associated with exposure to asbestos.
11p vinaypyidaw2711 26-08-2020 11 1 Download
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We have determined the cDNA nucleotide sequence, deduced the amino acid sequence and defined the gene structure for the cellular heart-type (H-FABP) or fatty acid-binding protein 3 (FABP3) from zebrafish. The zebrafish FABP3 exhibited the greatest amino acid sequence identity to fish andmammalian heart-type FABPs. 3¢RACE and 5¢ RLM-RACE mapped two alternative polyadenylation sites and three transcription start sites, respectively.
12p tumor12 20-04-2013 33 1 Download
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Apsychrotrophic bacteriumShewanellasp. strain SIB1 was grown at 4 and 20C, and total soluble proteins extracted from the cells were analyzed by two-dimensional poly-acrylamide gel electrophoresis. Comparison ofthese pat-terns showed that the cellular content ofa protein with a molecular mass of28 kDa and an isoelectric point of four greatly increased at 4 C compared to that at 20C.
10p dell39 03-04-2013 42 3 Download
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We have cloned and determined the nucleotide sequence of the cDNAcoding for a cellular retinol-bindingprotein type I (CRBPI)from zebrafish. The deduced amino acid sequence of the zebrafish CRBPI showed highest sequence identity (59%)to the mammalian CRBPIs of the intracellular lipid-binding protein (iLBP)multigene family. Phylogenetic analysis clustered the zebrafish CRBPI to the CRBPI clade. The zebrafish CRBPI gene (rbp1)and CRBPII gene (rbp2) both consist of four exons separated by three introns, iden-tical to all otheriLBP genes in vertebrates....
10p dell39 03-04-2013 43 2 Download