Development of fluorescent probes

Ebook Biophysics: Part 2 includes contents: Thermoluminescence in chloroplast thylakoid, chlorophyll fluorescence in plant biology, electromagnetic radiation and life - bioelementological point of view, recent developments in the study of the behavior of fluor escent membrane probes in lipid bilayers - molecular dynamics approach.

88p longtimenosee03 30-01-2024 4 2   Download

Ebook "Anti-cancer N-heterocyclic carbene complexes of Gold(III), Gold(I) and Platinum(II): Thiol “switch-on” fluorescent probes, thioredoxin reductase inhibitors and endoplasmic reticulum targeting agents" focuses on the development of gold- and non-classical platinum-based anti-cancer agents that display distinctively different anti-cancer mechanisms compared to the commonly used cisplatin.

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The advancement of functional nanomaterials has promoted the development of biomarker sensors underpinning promising analytical tools for a range of bioanalytes such as cholesterol. In this work, we established a light-on fluorescent probe for cholesterol in human serum by coordination of H2O2 on the surface of praseodymia nanorods (Pr6O11 NRs).

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In this study, a novel spectrofluorometric assay based on p-cresol (4-methyl phenol) probe is developed for the measurement of HOBr scavenging activity. It is the first study involving the use of a p-cresol probe for the determination of the HOBr scavenging activity of biothiols. While the p-cresol probe (λex = 260 nm, λem = 305 nm) has fluorescence characteristics, its brominated derivatives emerging at the end of the oxidation reaction with HOBr do not show fluorescence.

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A fluorescent probe based on silicon quantum dots (SiQDs) was developed for the selective and sensitive detection of oxytetracycline (OTC) via the inner filter effect (IFE). The water-soluble fluorescent SiQD was synthesized based on the reaction of 3-Aminopropyltriethoxysilane (APTES) and sodium citrate as precursors by the one-pot hydrothermal process. The strong fluorescence emission of quantum dots (QDs) was obtained at 440 nm when excited at 350 nm and OTC had a broad absorption band between 200 and 400 nm.

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Hydrazine (N2H4) is an important and commonly used chemical reagent for the preparation of textile dyes, pharmaceuticals, pesticides and so on. Despite its widespread industrial applications, hydrazine is highly toxic and exposure to this chemical can cause many symptoms and severe damage to the liver, kidneys, and central nervous system. As a consequence, many efforts have been devoted to the development of fluorescent probes for the selective sensing and/or imaging of N2H4.

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Chromosomal variants play important roles in crop breeding and genetic research. The development of single-stranded oligonucleotide (oligo) probes simplifies the process of fluorescence in situ hybridization (FISH) and facilitates chromosomal identification in many species.

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Elucidating the precise properties of cancer stem cells (CSCs) is indispensable for the development of effective therapies against tumors, because CSCs are key drivers of tumor development, metastasis and relapse.

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Fluorescent and colored trinitrophenylated (TNP) analogs of ATP and GTP can interact with nucleotide-requiring enzymes and proteins as a substitute for the parent nucleo-tide. These analogs have strong binding affinities for most nucleotide-requiring systems. Their bindings are easily detected by absorption and fluorescence changes in the visi-ble region.Recent years have seendramatic developments in the application of the TNP nucleotide analogs as spectro-scopic probes for the study on the nucleotide-interacting properties of various enzymes and proteins including their mutants.

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The development of targeted probes (based on the molecular engineering of luminescent or fluorescent proteins) has allowed the specific measure-ment of [Ca 2+ ] in intracellular organelles or cytoplasmic subdomains. This approach gave novel information on different aspects of cellular Ca 2+ homeostasis. Regarding mitochondria, it was possible to demonstrate that, upon physiological stimulation of cells, Ca 2+ is rapidly accumulated in the matrix.

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