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Development of resistance
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5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets.
16p
vishanshan
27-06-2024
2
1
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The implementation of antibiotic intravenous-to-oral switch (IVOS) therapy in hospitals can slow down the development of drug resistance, reduce the occurrence of adverse reactions, and bring significant economic benefits. The aim of this study is to investigate the understanding of physicians at the Second Affiliated Hospital of Soochow University in Suzhou, China towards the antibiotic IVOS therapy.
8p
vishanshan
27-06-2024
2
1
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The development of drug resistance is a major cause of cancer therapy failures. To inhibit drug resistance, multiple drugs are often treated together as a combinatorial therapy. In particular, synergistic drug combinations, which kill cancer cells at a lower concentration, guarantee a better prognosis and fewer side effects in cancer patients.
16p
vikoch
27-06-2024
2
1
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Copy-number alterations (CNAs) are a hallmark of cancer and can regulate cancer cell states via altered gene expression values. Herein, we have developed a copy-number impact (CNI) analysis method that quantifies the degree to which a gene expression value is impacted by CNAs and leveraged this analysis at the pathway level.
14p
vikoch
27-06-2024
1
1
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Part 1 book "Passive, active, and digital filters" includes content: General characteristics of filters; approximation; frequency transformations; sensitivity and selectivity; passive immittances and positive real functions; passive cascade synthesis; synthesis of LCM and RC one port networks; two part synthesis by ladder development; design of resistively terminated networks; design of broadband matching networks.... and other contents.
417p
dianmotminh03
17-06-2024
1
0
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In this study, the effect of nanoclay content on the fire resistance performances of intumescent coatings using ammonium polyphosphate (APP), pentaerythritol (PER), and melamine (MEL) is investigated. The epoxy and nanoclay-based intumescent coatings were developed to serve as coatings for steel substrates.
8p
viambani
18-06-2024
2
1
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Ebook Information technology project management presents the following content: Chapter 1: the nature of IT projects; chapter 2: conceptualizing and initializing the IT project; chapter 3: developing the project charter and baseline project plan; chapter 4: the human side of project management; chapter 5: defining and managing project scope; chapter 6: the work breakdown structure and project estimation; chapter 7: the project schedule and budget; chapter 8: managing project risk; chapter 9: project communication, tracking, and reporting; chapter 10: it project quality management; chapter 1...
330p
zizaybay1103
29-05-2024
3
2
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Part 1 book "Air conditioning and refrigeration" includes content: Air conditioning and refrigeration tools and instruments; development of refrigeration; voltage, current, and resistance; solenoids and valves; electric motors - selection, operational characteristics and problems; refrigerants - new and old; refrigeration compressors; condensers, chillers, and cooling towers; working with water cooling problems; evaporators.
320p
dianmotminh01
20-05-2024
2
2
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The paper proposes a comprehensive model for resistance economy focused on intellectual capital in order to achieve a progressive, resilient, stable, and productive economy which is one of the primary goals of each nation, thus enabling decision-makers to provide opportunities for reconstructing and improving systematic performance and take advantage of the resulting complex changes to introduce positive social developments.
20p
longtimenosee10
26-04-2024
2
2
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We investigate students’ misconceptions in electrostatics, direct current (DC) and magnetism which are important in electricity and magnetism. We developed and administered a multiple-choice questionnaire test to reveal students’ misconceptions related to charged bodies, lightning, electric fields, electric potential, forces, DC resistive electric circuits and magnets.
19p
viarnault
25-04-2024
3
2
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Ebook "Self and nonself" focuses on the origin of the immune response during the development of multicellularity (Chapters 1-4). Bacteria have developed defense systems against viruses and conversely, viruses have devised escape mechanisms that allow infection. Most of the archaea and numerous bacteria possess an elaborate system of adaptive immunity known as the CRISPR-Cas, that confers resistance to mobile genetic elements.
338p
tracanhphuonghoa1007
22-04-2024
1
1
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Ebook "Fungal biofilms and related infections: Advances in microbiology, infectious diseases and public health (Volume 3)" covers the latest data available to understand the mechanisms causing the formation of single species fungal biofilms or polymicrobial biofilms involving fungal species; specific chapters present hot topics such as resistance mechanisms and composition and role of the matrix. Moreover, it reviews updated data on biofilms that contain yeasts or filamentous fungi and develop in the human body or in water and may cause infections.
129p
tracanhphuonghoa1007
22-04-2024
7
2
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Targeted therapies specifically act by blocking the activity of proteins that are encoded by genes critical for tumorigenesis. However, most cancers acquire resistance and long-term disease remission is rarely observed. Understanding the time course of molecular changes responsible for the development of acquired resistance could enable optimization of patients’ treatment options.
22p
vibransone
28-03-2024
3
2
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The 2014–2016 Ebola virus (EBOV) outbreak in West Africa highlighted the need for improved therapeutic options against this virus. Approaches targeting host factors/pathways essential for the virus are advantageous because they can potentially target a wide range of viruses, including newly emerging ones and because the development of resistance is less likely than when targeting the virus directly.
14p
vibransone
28-03-2024
2
2
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The modern techniques of microbiome science can be applied to the development and evaluation of all microbiota-directed products, including probiotics and fecal microbiota transplantation. The advent of high-throughput sequencing technologies and advanced computational techniques has enabled a paradigm shift in how scientists view and study the microbial world.
3p
vibransone
28-03-2024
2
2
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Staphylococcus aureus is an opportunistic pathogen and a leading cause of nosocomial infections. It can acquire resistance to all the antibiotics that entered the clinics to date, and the World Health Organization defined it as a high-priority pathogen for research and development of new antibiotics.
19p
vibransone
28-03-2024
5
2
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Patients diagnosed with high-grade serous ovarian cancer (HGSOC) who received initial debulking surgery followed by platinum-based chemotherapy can experience highly variable clinical responses. A small percentage of women experience exceptional long-term survival (long term (LT), 10+ years), while others develop primary resistance to therapy and succumb to disease in less than 2 years (short term (ST)).
17p
vibransone
28-03-2024
2
1
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Tumor cell-intrinsic mechanisms and complex interactions with the tumor microenvironment contribute to therapeutic failure via tumor evolution. It may be possible to overcome treatment resistance by developing a personalized approach against relapsing cancers based on a comprehensive analysis of cell typespecific transcriptomic changes over the clinical course of the disease using single-cell RNA sequencing (scRNA-seq).
21p
vibransone
28-03-2024
3
2
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Clinical whole-genome sequencing (WGS) offers clear diagnostic benefits for patients with rare disease. However, there are barriers to its widespread adoption, including a lack of standards for clinical practice. The Medical Genome Initiative consortium was formed to provide practical guidance and support the development of standards for the use of clinical WGS.
4p
vibransone
28-03-2024
4
2
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Dietary glycans, widely used as food ingredients and not directly digested by humans, are of intense interest for their beneficial roles in human health through shaping the microbiome. Characterizing the consistency and temporal responses of the gut microbiome to glycans is critical for rationally developing and deploying these compounds as therapeutics.
16p
vibransone
28-03-2024
6
2
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