Disease activity assessment
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This study was conducted to assess factors related to the nutrition status among older patients with Parkinson’s disease (PD) in 2023. A cross-sectional study was conducted on participants aged over 60 years old having PD at the National Geriatric Hospital from February 2023 to October 2023.
10p vikoch 27-06-2024 1 1 Download
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Cancer is the most destructive and fatal disease, representing an urgent medical challenge to the world. The discovery of a new anticancer candidate may help reduce or eliminate this alarming disease to a greater extent. On similar lines, in silico research was carried out on novel naphthylidene isoxazolidinedione derivatives that were logically conceived, synthesized, purified, and structurally characterized. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells.
10p dianmotminh02 03-05-2024 4 1 Download
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. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.
10p dianmotminh02 03-05-2024 2 2 Download
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Hepatocellular carcinoma (HCC) is a fatal disease characterized by early genetic alterations in telomerase reverse transcriptase promoter (TERTp) and β-catenin (CTNNB1) genes and immune cell activation in the tumor microenvironment. As a novel approach, we wanted to assess patient survival influenced by combined presence of mutations and densities of CD8+ cytotoxic T cells.
10p vialfrednobel 23-12-2023 4 3 Download
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Part 2 book "Disease in wild animals, investigation and management" includes content: Disease management through manipulation of the host population, disease management through treatment and immunization, disease management through environmental modification, disease management through influencing human activities, emergency and integrated management programs, assessing the effectiveness of a disease-management program.
173p oursky10 04-12-2023 8 3 Download
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Comparative assessment of antibacterial and antifungal activities of metallic ion based formulations
The present study aims to investigate the potential of the new formulations including silver (I) nanoparticles as well as copper (II) and zinc (II) chelates in their separated and complex forms in the treatment of infectious diseases. The capacity of metallic ion based systems to suppress the development of microorganism often seen on wounds, such as Gram-negative bacteria (Klebsiella pneumonia ATCC 700603, Pseudomonas aeruginosa ATCC 27853), Gram-positive bacteria (Staphylococcus aureus ATCC 29213), and fungi (Candida albicans ATCC 10231) were evaluated by microdilution assay.
6p giangnhanly 02-10-2023 4 3 Download
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The tomato (Lycopersiconesculentum Mill) is a herbaceous plant of the Solanaceae family widely cultivated for its fruit. This study aims to evaluate the antihypertensive and antihyperhocysteinemic activity of two varieties of tomatoes grown in Côte d'Ivoire, namely Locale côtelette and Cobra F1.
10p viisac 23-09-2023 2 1 Download
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Demodicidosis is a chronic skin disease, caused by two species of Demodex (D. folliculorum and D. brevis). Demodex infected individuals are mainly symptomless and may have pathogenic symptom only when mite density is high within the skin. Objectives: To compare the value of the Standardized skin surface biopsy (SSSB) and direct microscopic examination with KOH (DME) for assessing Demodex density.
6p viberbers 09-08-2023 6 2 Download
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Over the past decades, researchers and scientists have paid more and more attention to the discovery of novel antibiotics and anticancer agents in fighting infection and cancer diseases. It is believed that endophytic actinomycetes from medicinal plants provide abundant resources for new compounds with significant bioactive properties. In the present study, we assessed antibacterial and cytotoxic activities of endophytic actinomycetes associated with Litsea cubeba (Lour.) Pers.
11p vidudley 20-02-2023 7 2 Download
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In this work, the application of betaine-based hydrophilic natural deep eutectic solvents (NADESs) as green extraction solvents was proposed for the first time for the evaluation of twelve pesticides in citrus and olive by-products intended to be applied as potential sources of compounds with neuroprotective activity against Alzheimer Disease.
12p viginny 23-12-2022 10 3 Download
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Sedentary behavior (SB) is an independent risk factor causing chronic diseases. Previous studies compared sitting time mostly with physical activity. The present study aimed to evaluate the validity and reliability of the Last-7-Day Sedentary Time Questionnaire (SIT-Q-7d) in Iran. Moreover, SB was assessed among the study participants.
10p viferrari 29-10-2022 7 2 Download
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Physical inactivity is one of the major risk factors for non-communicable diseases. Few studies about physical activity have been conducted among refugees from neighbouring countries. Given changes in the situation of Syrians, assessment of physical activity among Syrian refugees is required to understand their situation.
15p viferrari 29-10-2022 4 2 Download
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Timely risk stratification is the key strategy to improve prognosis of patients with sepsis. Previous study has proposed to develop a powerful risk assessment rule by the combination of Acute Physiology and Chronic Health Evaluation II (APACHE II) score and plasma soluble urokinase plasminogen activator receptor (suPAR).
9p viottohahn 30-03-2022 9 1 Download
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Ability in the activities of daily life is often impaired in the older adults with a neurological disease. The Barthel Index is an instrument used worldwide to assess such ability. The Longshi Scale is a picture-based alternative, but its effectiveness has not been evaluated with older adult subjects. This study was to determine whether the Longshi Scale can effectively quantify the ability of older adults in the activities of daily living by comparing its ratings with those using the Barthel Index.
9p vinobelprisen 26-03-2022 9 5 Download
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Barthel Index (BI) is one of the most widely utilized tools for assessing functional independence in activities of daily living. Most existing BI studies used populations with specific diseases (e.g., Alzheimer’s and stroke) to test prognostic factors of BI scores; however, the generalization of these findings was limited when the target populations varied.
12p vinobelprisen 26-03-2022 15 5 Download
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Frailty is an expression of vulnerability and decline of physical, mental, and social activities, more commonly found in older adults. It is also closely related to the occurrence and poor prognosis of coronary artery disease (CAD). Little investigation has been conducted on the prevalence and determinants of frailty in older adult patients with chronic coronary syndrome (CCS).
9p vinobelprisen 26-03-2022 15 4 Download
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Gamithromycin is a macrolide approved for the treatment of bovine and swine respiratory diseases. Our study aims to establish the clinical breakpoint and optimum dose regimen for gamithromycin against Haemophilus parasuis in piglets.
12p vigalileogalilei 28-02-2022 12 2 Download
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The aim of the study was to assess the value of MRE in imaging of small bowel lesions, their location and extent, in CD patients and its correlation with clinical and endoscopic activity.
9p lazzaro 30-12-2021 2 0 Download
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Malignant mesothelioma (MM) is a relatively rare and highly lethal tumor with few treatment options. Thus, it is important to identify prognostic markers that can help clinicians diagnose mesothelioma earlier and assess disease activity more accurately.
18p vimahuateng 26-11-2021 9 1 Download
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Transposable elements (TEs) are mobile genetic sequences that randomly propagate within their host’s genome. This mobility has the potential to affect gene transcription and cause disease. However, TEs are technically challenging to identify, which complicates efforts to assess the impact of TE insertions on disease. Here we present a targeted sequencing protocol and computational pipeline to identify polymorphic and novel TE insertions using next-generation sequencing: TE-NGS.
14p vibeauty 23-10-2021 9 1 Download