Disease structure

This paper is structured as follows. The following section presents related work. Section 3 summarizes the characteristics of the two datasets utilized in the model and the system’s overall architecture for image-based disease diagnosis. Section 4 provides our experimental results that compare the performance metrics with other studies.

6p viengfa 28-10-2024 2 2   Download

We aimed to describe the disease structure and the results of treatment of the inpatients at the Department of Spinal Trauma and Orthopedics, Military Central Hospital 108, from 2017 to 2021.

5p viironman 02-06-2023 5 2   Download

The thesis is structured as follows: In Chapter 1, the scientific literature is summarized within the scope of this study. Chapter 2 provides a comprehensive overview of the principles of the applied computational approaches in this study. Chapter 3 identifies the important residues of the LsIA/α7 nAChR complex that affect the interactions between the toxin and the membrane protein due to C-terminal carboxylation of LsIA. The effects of C-terminal modification of LsIA on interactions with α3β2 nAChR, involved in cardiovascular diseases, were also investigated in Chapter 4.

234p runthenight04 02-02-2023 11 3   Download

Master's thesis of Science "Analysis of coffee-herbal beverages for potential benefits against dementia diseases" is structured as follows: Chapter 1: Introduction; Chapter 2: Coffee herbal bioactive compound’s potential to prevent dementia; Chapter 3: The analysis of coffee herbal beverages; Chapter 4: Coffee herbal beverage sensory estimation; Chapter 5: Conclusions and further work; Appendix 1: Herbal coffee beverage sensory analysis evaluation.

100p runthenight04 02-02-2023 3 3   Download

Smilax glabra Roxb. is a medicinal plant of Vietnam to treat several diseases such as: Piercing pain in the bones, detoxicating, scabies, nephritis, cystitis, syphilis,... From ethanol extracts of Smilax glabra Roxb. cultivating in Thai Nguyen, 5 compounds were isolated and structurally elucidated in the first time by various spectral methods, such as IR, MS, 1H-NMR, 13C-NMR, DEPT, HSQC, HMBC.

9p larachdumlanat127 20-12-2020 19 3   Download

Development of knowledge of cardiovascular diseases and treatments strongly depends on understanding of hemodynamic measurements. Hemodynamic parameters, therefore, have been investigated using simulation-based methods.

10p tohitohi 19-05-2020 17 1   Download

The aims of the dissertation are: Extracting and determining the structure of organic compounds of four plant species with potential for insecticide and fungal diseases. Isolating endogenous fungi from plant samples, extracting and determining the structure of component organic compounds. Testing of insecticidal and fungal activity of extracts and component organic compounds.

35p xacxuoc4321 08-07-2019 33 3   Download

Dental X-ray image segmentation is a necessary and important process in medical diagnosis, which assists clinicians to make decisions about possible dental diseases of a patient from a dental X-ray image. It is a multi-objective optimization problem which involves basic components of fuzzy clustering, spatial structures of a dental image, and additional information of experts expressed through a pre-defined membership matrix.

17p dieutringuyen 07-06-2017 53 2   Download

Plasmodium falciparum malaria remains a serious endemic disease in many parts of the world. It is estimated that 120 million cases occur worldwide each year, causing over one million deaths. The problem has been compounded by the emergence of strains of P. falciparum resistant to virtually all antimalarial agents. Resistance to chloroquine has now spread to almost all areas where malaria is endemic. Chloroquine-resistant strains are typically cross resistant to all drugs of relative chemical structure, and therefore the need for finding new molecules with novel modes of action is urgent.

4p uocvong04 24-09-2015 36 4   Download

The human immunodeficiency virus type 1, HIV-1, genome encodes a highly conserved regulatory gene product, Vpr (96 amino acids), which is incorporated into virions in quantities equivalent to those of the viral Gag protein. In infected cells, Vpr is believed to function during the early stages of HIV-1 replication (such as transcription of the proviral genome and migration of preintegration nuclear complex), blocks cells in G2 phase and triggers apoptosis.

10p system191 01-06-2013 46 4   Download

Bacteroides vulgatus has been shown to be involved in the aggravation of colitis. Previously, we separated two potent virulence factors, capsular polysaccharide (CPS) and lipopolysaccharide (LPS), from a clinical isolate of B. vulgatus and characterized the structure of CPS. In this study, we elucidated the structures of O-antigen polysaccharide (OPS) and lipid A in the LPS. LPS was subjected to weak acid hydrolysis to produce the lipid A fraction and polysaccharide fraction.

7p system191 01-06-2013 50 8   Download

Trypanosoma brucei is the cause of the diseases known as sleeping sickness in humans (T. brucei ssp. gambiense and ssp. rhodesiense) and ngana in domestic animals (T. brucei brucei) in Africa. Procyclic trypomastigotes, the tsetse vector stage, express a surface-bound trans-sialidase that transfers sialic acid to the glycosylphosphatidylinositol anchor of procyclin, a surface glycoprotein covering the parasite surface. Trans-sialidase is a unique enzyme expressed by a few trypanosomatids that allows them to scavenge sialic acid from sialylated compounds present in the infected host. ...

10p system191 01-06-2013 44 4   Download

Agrobacterium tumefaciens is a Gram-negative, phytopathogenic bacterium and is characterized by an unique mode of action on dicotyledonous plants: it is able to genetically modify the host, and because of this feature, it is used as a tool for transgenic plants. Many experiments have demonstrated that lipopolysaccharides (LPSs) play an important role for the disease development, as they are involved in the adhesion process of the bacterium on the plant cell wall.

4p system191 01-06-2013 32 4   Download

Mitochondrial functional and structural impairment and generation of oxidative stress have been implicated in aging, various diseases and chemotherapies. This study analyzed azidothymidine (AZT)-caused failures in mitochondrial functions, in redox regulation and activation of the HIV-1 gene expression. We monitored intracellular concentrations of ATP and glutathione (GSH) as the indicators of energy production and redox conditions, respectively, during the time-course experiments with U937 and MOLT4 human lymphoid cells in the presence of AZT (0.05 mgÆmL)1) or H2O2 (0.01 mM) for 15–25 days.

7p system191 01-06-2013 42 3   Download

The phenomenon of the transformation of proteins into amyloid-fibrils is of interest, firstly, because it is closely connected to the so-called conformational diseases, many of which are hitherto incurable, and secondly, because it remains to be explained in physical terms (energetically and structurally). The process leads to fibrous aggregates in the form of extracellular amyloid plaques, neuro-fibrillary tangles and other intracytoplasmic or intranuclear inclusions.

10p research12 01-06-2013 32 4   Download

The casein milk proteins and the brain proteinsa-synuclein and tau have been described as natively unfolded with ran-domcoil structures,which, inthecaseofa-synucleinandtau, have a propensity to form the ®brils found in a number of neurodegenerative diseases. New insight into the structures of these proteins has been provided by a Raman optical activity study, supplemented with di€erential scanning cal-orimetry, of bovineb-andj-casein, recombinant humana-, b-andc-synuclein,

9p research12 29-04-2013 41 4   Download

Cyclin-dependent kinase-5 (Cdk5) is a serine/threonine kinase activated by its neuron-specific activator, p35, or its truncated form, p25. It has been proposed that the deregu-lation of Cdk5 activity by association with p25 in human brain tissue disrupts the neuronal cytoskeleton and may be involved in neurodegenerative diseases such as Alzheimer’s disease.

8p research12 23-04-2013 32 2   Download

A structuring and eventual exclusion of water surrounding backbone hydrogen bonds takes place during protein fold-ing as hydrophobic residues cluster around such bonds. Taken as an average over all hydrogen bonds, the extent of desolvation is nearly a constant of motion, as revealed by re-examination of the longest all-atom trajectory with explicit solvent [Y.Duan & P.A.Kollman (1998)Science 282, 740].Furthermore, this extent of desolvation is pre-served across native soluble proteins, except for cellular prion proteins....

4p research12 23-04-2013 32 2   Download

BACE2 (Memapsin 1) is a membrane-bound aspartic pro-tease that is highlyhomologouswithBACE1 (Memapsin 2). While BACE1 processes the amyloid precursor protein (APP) at a key step in generating theb-amyloid peptide and presumably causes Alzheimer’s disease (AD), BACE2 has not been demonstrated to be directly involved in APP pro-cessing, and its physiological functions remain to be deter-mined.In vivo, BACE2 is expressed as a precursor protein containing pre-, pro-, protease, transmembrane, and cyto-solic domains/peptides....

10p tumor12 22-04-2013 25 2   Download

The major components of neuritic plaques found in Alzheimer disease (AD) are peptides known as amyloid b-peptides (Ab),which derive from the proteolitic cleavage of theamyloidprecursorproteins.InvitroAbmayundergoa conformational transition from a soluble form to aggrega-ted,fibrillary b-sheet structures,which seem to be neuro-toxic. Alternatively,it has been suggested that ana-helical form can be involved in a process of membrane poration, which would then trigger cellular death.

7p tumor12 22-04-2013 36 2   Download