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Drug discovery process
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The third edition of this best-selling book continues to offer a user-friendly, step-by-step introduction to all the key processes involved in bringing a drug to the market, including the performance of pre-clinical studies, the conduct of human clinical trials, regulatory controls, and even the manufacturing processes for pharmaceutical products.
555p
vimeyers
29-05-2024
3
2
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Ebook "Complement therapeutics" highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis.
323p
ladongphongthanh1008
22-04-2024
3
3
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Part 2 book "Ectoparasites drug discovery against moving targets" includes content: Molecular targets to impair blood meal processing in ticks, whole‐organism screens for ectoparasites, testing in laboratory animal models for ectoparasiticide discovery and development, testing in target hosts for ectoparasiticide discovery and development,... and other contents.
213p
oursky04
14-09-2023
2
2
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Cardiovascular diseases are one of the leading cause of mortality and morbidity worldwide. Although many efforts have been made in the drug discovery and development process through decades, the number of approved drugs has been declining.
12p
viberkshire
09-08-2023
3
2
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A fast determination of acidity constants (pKa) of very insoluble drugs has become a necessity in drug discovery process because it often produces molecules that are highly lipophilic and sparingly soluble in water. In this work the high throughput internal standard capillary electrophoresis (IS-CE) method has been adapted to the determination of pKa of water insoluble compounds by measurement in methanol/aqueous buffer mixtures.
10p
viginny
23-12-2022
8
3
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In the second part, recent database of compounds provided worldwide and drug-like parameters which are helpful in supporting for the virtual screening process will be discussed. This information will provide a good platform to estimate the advance of applying these techniques in the new drug-lead identification and optimization.
26p
spiritedaway36
25-11-2021
6
1
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Drug discovery and development has been aided by high throughput screening methods that detect compound effects on a single target. However, when using focused initial screening, undesirable secondary effects are often detected late in the development process after significant investment has been made.
11p
vikentucky2711
26-11-2020
8
0
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Structure-based drug design is an iterative process, following cycles of structural biology, computer-aided design, synthetic chemistry and bioassay. In favorable circumstances, this process can lead to the structures of hundreds of protein-ligand crystal structures. In addition, molecular dynamics simulations are increasingly being used to further explore the conformational landscape of these complexes.
18p
vikentucky2711
26-11-2020
9
1
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Active learning is a powerful tool for guiding an experimentation process. Instead of doing all possible experiments in a given domain, active learning can be used to pick the experiments that will add the most knowledge to the current model. Especially, for drug discovery and development, active learning has been shown to reduce the number of experiments needed to obtain high-confidence predictions.
10p
vikentucky2711
24-11-2020
12
1
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The targeting of disease-related proteins is important for drug discovery, and yet target-based discovery has not been fruitful. Contextualizing overall biological processes is critical to formulating successful drugdisease hypotheses.
18p
vioklahoma2711
19-11-2020
4
1
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Multiple computational methods for predicting drug-target interactions have been developed to facilitate the drug discovery process. These methods use available data on known drug-target interactions to train classifiers with the purpose of predicting new undiscovered interactions.
10p
vioklahoma2711
19-11-2020
10
1
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Despite being hugely important in biological processes, allostery is poorly understood and no universal mechanism has been discovered. Allosteric drugs are a largely unexplored prospect with many potential advantages over orthosteric drugs. Computational methods to predict allosteric sites on proteins are needed to aid the discovery of allosteric drugs, as well as to advance our fundamental understanding of allostery.
7p
vioklahoma2711
19-11-2020
9
1
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Drug repositioning is the process of identifying new targets for known drugs. It can be used to overcome problems associated with traditional drug discovery by adapting existing drugs to treat new discovered diseases.
14p
viconnecticut2711
29-10-2020
15
1
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Drug discovery is the process through which potential new medicines are identified. High-throughput screening and computer-aided drug discovery/design are the two main drug discovery methods for now, which have successfully discovered a series of drugs.
11p
viconnecticut2711
28-10-2020
17
0
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De novo drug discovery is a time-consuming and expensive process. Nowadays, drug repositioning is utilized as a common strategy to discover a new drug indication for existing drugs. This strategy is mostly used in cases with a limited number of candidate pairs of drugs and diseases.
11p
vicolorado2711
23-10-2020
12
0
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In the quest for new anti-cancer drugs, the drug discovery process has shifted to screening of active ingredients in traditional eastern medicine. Matrine is an active alkaloid isolated from plants of the Sophora genus used in traditional Chinese herbal medicine that exhibits a wide spectrum of biological properties and has a potential as an anti-proliferative agent.
12p
vikuala271
13-06-2020
13
1
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The discovery that not all agonists uniformly activate cellular signaling pathways (biased signaling) has greatly changed the drug discovery process for agonists and the strategy for treatment of disease with agonists.
8p
viorochimaru2711
30-05-2020
7
1
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Lipophilicity is a physicochemical property of an essential importance in medicinal chemistry; therefore, fast and reliable measurement of lipophilicity will effect greatly the drug discovery process.
7p
vijiraiya2711
27-05-2020
8
1
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Drug-induced cardiac toxicity has been implicated in 31% of drug withdrawals in the USA. The fact that the risk for cardiac-related adverse events goes undetected in preclinical studies for so many drugs underscores the need for better, more predictive in vitro safety screens to be deployed early in the drug discovery process.
12p
vienzym2711
03-04-2020
11
3
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Antibiotic resistance and the particular emergence of multi - resistant bacterial strains are clinically relevant issue involving serious threats to public health worldwide. DNA methylation, which changes the affinity and interaction of regulatory proteins with DNA, is an epigenetic mechanism that regulates numerous bacterial physiological processes, including chromosome replication, DNA segregation, mismatch repair, transposition and transcription.
11p
quenchua2
15-12-2019
6
0
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