Drug discovery

Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.

10p caothientrangnguyen 09-05-2020 13 1   Download

The objectives of the thesis: Molecular docking studies on acetylcholinesterase were performed to predict the chalcone structure has good in silico AChE acetylcholinesterase inhibitory activity. The potential chalcone compounds were synthesized and studied for their in vitro and in vivo AChE inhibitory activities

25p xacxuoc4321 09-07-2019 43 7   Download

Polyamine oxidase (PAO) and spermine oxidase (SMO) are involved in the catabolism of polyamines – basic regulators of cell growth and prolifer-ation. The discovery of selective inhibitors of PAO and SMO represents an important tool in studying the involvement of these enzymes in polyamine homeostasis and a starting point for the development of novel antineoplas-tic drugs.

9p inspiron33 26-03-2013 41 5   Download

The recent discovery of the direct oxidation of spermine via spermine oxi-dase (SMO) as a mechanism through which specific antitumor polyamine analogues exert their cytotoxic effects has fueled interest in the study of the polyamine catabolic pathway.

12p media19 06-03-2013 48 3   Download

4-Diphosphocytidyl-2C-methyl-d-erythritol kinase (IspE) catalyses the ATP-dependent conversion of 4-diphosphocytidyl-2C-methyl-d-erythritol (CDPME) to 4-diphosphocytidyl-2C-methyl-d-erythritol 2-phosphate with the release of ADP.

16p media19 06-03-2013 34 1   Download

The Protein Data Bank contains the description of approximately 27 000 protein–ligand binding sites. Most of the ligands at these sites are biologi-cally active small molecules, affecting the biological function of the protein. The classification of their binding sites may lead to relevant results in drug discovery and design.

9p mobifone23 18-01-2013 46 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Digital drug discovery...

3p thulanh19 09-11-2011 24 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Meeting the challenges of drug discovery: a multidisciplinary re-evaluation of current practices...

3p thulanh19 09-11-2011 40 2   Download

We have come so far so fast in understanding RNA interference (RNAi) and its central role in biology. Rarely has a novel mechanism in molecular genetics had such broad implications, ranging from gene therapy and drug discovery to our very understanding of what the word ‘gene’ means. Every major pharmaceutical company has a substantial effort now in RNAi technology, and among the smaller biotechnology companies RNAi is the mainstay of several, with

3p thulanh19 09-11-2011 49 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Distribution patterns of small-molecule ligands in the protein universe and implications for origin of life and drug discovery...

13p thulanh19 05-11-2011 42 4   Download