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Drug receptors
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This research designeded to: 1. Analyze the efficacy and safety of Palbociclib treatment in HR-positive and HER2-negative (HR+/HER2-) metastatic breast cancer(MBC) patients. 2. Establish and validate a nomogram model for predicting the progression-free survival (PFS) rates of 6 months, 12 months, and 18 months in HR+/HER2- MBC patients after receiving Palbociclib plus endocrine therapy (ET).
13p
vishanshan
27-06-2024
1
1
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The potential efficacy of metformin in breast cancer (BC) has been hotly discussed but never conclusive. This genetics-based study aimed to evaluate the relationships between metformin targets and BC risk.
11p
vikoch
27-06-2024
1
1
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The partitioned survival model (PSM) and the state transition model (STM) are widely used in costeffectiveness analyses of anticancer drugs. Using different modeling approaches with or without consideration of brain metastasis, we compared the quality-adjusted life-year (QALY) estimates of Osimertinib and pemetrexedplatinum in advanced non-small cell lung cancer with epidermal growth factor receptor mutations.
11p
vikoch
27-06-2024
1
1
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Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. Acquired functional mutations in the tyrosine-protein kinase growth factor receptor proto-oncogene (KIT) and platelet-derived growth factor-alpha gene lead to increased tyrosine kinase activity, which is considered a key factor in the pathogenesis of GIST.
14p
vikoch
27-06-2024
1
1
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This volume provides current methods to analyze the properties of designer receptors exclusively activated by designer drugs (DREADDs) in vitro and to measure the biological responses of DREADD activation in different neuronal populations in vivo. Chapters focus on the utility of DREADD technology to selectively stimulate or inhibit neuronal activity in selected brain areas of transgenic mice.
175p
vimeyers
29-05-2024
3
2
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Metabolic inhibitors and receptor antagonists are indispensable tools for the molecular life scientist. By blocking specific enzymes or receptor-mediated signal transduction cascades, they simplify the analysis of complex cellular processes especially when it is essential to demonstrate that a process of interest is functionally linked to a particular enzyme or receptor.
1368p
vimeyers
29-05-2024
5
2
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Part 1 book "Basic and clinical pharmacology" includes contents: Introduction - The nature of drugs and drug development and regulation, drug receptors and pharmacodynamics, pharmacokinetics and pharmacodynamics - rational dosing and the time course of drug action, drug biotransformation, pharmacogenomics, introduction to autonomic pharmacology; cholinoceptor activating and cholinesterase inhibiting drugs; cholinoceptor blocking drugs; adrenoceptor agonists and sympathomimetic drugs, adrenoceptor antagonist drugs,... and other contents.
502p
dianmotminh01
17-05-2024
3
3
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Part 1 book "Goodman and gilmans the pharmacological basis of therapeutics" includes content: General principles, neuropharmacology, modulation of pulmonary, renal, and cardiovascular function, inflammation, immunomodulation, and hematopoiesis
774p
zizaybay1101
30-04-2024
2
2
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Part 1 book "Cardiac drug therapy" includes content: Beta blockers: The cornerstone of cardiac drug therapy - beta blocker controversies, angiotensin converting enzyme inhibitors and angiotensin II receptor blockers, ACE inhibitor ARB controversies, calcium antagonists (calcium channel blockers). calcium antagonist controversies, diuretics, hypertension, hypertension controversies.
336p
zizaybay1101
30-04-2024
4
1
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Ebook "Antibacterials (Volume I)" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...
203p
tracanhphuonghoa1007
22-04-2024
3
2
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Ebook "Small molecule therapeutics for schizophrenia" covers all relevant aspects of drug research, e.g.
327p
tracanhphuonghoa1007
22-04-2024
3
3
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Part 2 book "Fundamentals and applications of controlled release drug delivery" includes content: Targeted delivery using biodegradable polymeric nanoparticles; liposomes in drug delivery; receptor mediated delivery systems for cancer therapeutics, biological rhythms, drug delivery, and chronotherapeutics; site specific controlled release for cardiovascular disease - translational directions; drug delivery systems to fight cancer; fundamentals of vaccine delivery in infectious diseases; tissue engineering in drug delivery.
340p
muasambanhan10
03-04-2024
1
0
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Based on promising phase II data, the histone deacetylase inhibitor entinostat is in phase III trials for patients with metastatic estrogen receptor-positive breast cancer. Predictors of sensitivity and resistance, however, remain unknown.
14p
vibransone
28-03-2024
5
2
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Increases in α-synuclein protein expression are suspected to increase the risk of the development of Parkinson’s disease (PD). A recent study has demonstrated that β2-adrenergic receptor (β2AR) agonists decrease histone acetylation in the α-synuclein gene and suppress transcription.
3p
vioraclene
31-03-2024
3
2
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Continued part 1, part 2 of ebook "Practical chemoinformatics" provides readers with contents including: active site-directed pose prediction programs for efficient filtering of molecules; representation, fingerprinting, and modelling of chemical reactions; predictive methods for organic spectral data simulation; chemical text mining for lead discovery; ntegration of automated workflow in chemoinformatics for drug discovery;...
261p
tudohanhtau1006
29-03-2024
5
1
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Ebook "Chemokines: Chemokines and their receptors in drug discovery" covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level,...
248p
tudohanhtau1006
29-03-2024
1
1
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Ebook "Tactics in contemporary drug design" covers all relevant aspects of drug research, e.g.
400p
manmanthanhla0201
26-02-2024
2
1
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Ebook "The blood brain barrier (BBB)" covers all relevant aspects of drug research, e.g.
169p
nhanphanguyet
28-01-2024
5
2
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Ebook "Biochemical roles of eukaryotic cell surface macromolecules" covered include: neurochemical and biochemical analysis of cell surface glycoconjugates; membrane skeletal organization; GPCRs and other receptors; biophysical approaches to study membrane interactions; glycoconjugate metabolism; dysregulation; molecular mechanisms involved in cell-cell and cell-matrix interaction; glycans in infectious and neurological diseases; cancer and glycosyltransferases as drug targets.
408p
nhanphanguyet
28-01-2024
4
2
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Panic disorder and panic attacks are two of the most common problems in psychiatry. A psychoimmunological correlation between allergic diseases and panic disorder has been strongly suggested. Histamine H1 receptor antagonists have been suggested as alternative drugs for the treatment of panic disorder.
12p
vitiki
30-01-2024
2
2
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