Drug safety

This research designeded to: 1. Analyze the efficacy and safety of Palbociclib treatment in HR-positive and HER2-negative (HR+/HER2-) metastatic breast cancer(MBC) patients. 2. Establish and validate a nomogram model for predicting the progression-free survival (PFS) rates of 6 months, 12 months, and 18 months in HR+/HER2- MBC patients after receiving Palbociclib plus endocrine therapy (ET).

13p vishanshan 27-06-2024 1 1   Download

For chronic pain after thoracic surgery, optimal timing of its diagnosis and effective treatment remains unresolved, although several treatment options are currently available. We examined the efficacy and safety of mirogabalin, in combination with conventional pain therapy (nonsteroidal anti-infammatory drugs and/or acetaminophen), for treating peripheral neuropathic pain (NeP) after thoracic surgery.

15p vishanshan 27-06-2024 1 1   Download

A new class of antibody-based drug therapy with the potential for disease modification is now available for Alzheimer’s disease (AD). However, the complexity of drug eligibility, administration, cost, and safety of such disease modifying therapies (DMTs) necessitates adopting new treatment and care pathways.

12p vishanshan 27-06-2024 2 1   Download

Medical narcotics must be administered under medical supervision because of their potential for misuse and abuse, leading to more dangerous and addictive substances. The control of medical narcotics requires close monitoring to ensure that they remain safe and effective. This study proposes a methodology that can effectively identify the overprescription of medical narcotics in hospitals and patients.

12p vishanshan 27-06-2024 3 1   Download

Recent advances in the management of pancreatic neuroendocrine tumors (pNETs) highlight the potential benefits of temozolomide, an alkylating agent, for these patients. In this meta-analysis, we aimed to assess the outcome of temozolomide, alone or in combination with other anticancer medications in patients with advanced pNET.

15p vikoch 27-06-2024 1 1   Download

This book is a systemic summary of the research of Guo-Fang Pang’s team on the theory and applied practice of detection technology of pesticide residues over the past 20 years. The innovative research achievements at an internationally advanced level in this field are fully demonstrated in this work. In addition, the progress of food safety detection technology has been promoted.

658p vimeyers 29-05-2024 2 2   Download

This reference provides a concise overview of the key principles in dose selection and optimization and demonstrates applicability to recent successful new drug applications. Compiling key issues and current research on safety, efficacy, and clinical pharmacology, and PK-PD, this volume critically highlights the multidisciplinary nature of drug development and spans the fields of pharmacokinetics, clinical pharmacology, biostatistics, and experimental medicine.

301p vimeyers 29-05-2024 2 2   Download

Mesoporous silica nanoparticles (MSNs) have been used as an anticancer drug delivery system with high safety and entrapment capacity thanks to their large internal space for drug accommodation, durable structure, and good biocompatibility. However, the treatment efficiency of the bare MSNs is limited due to its drug leakage and burst release. In this study, a phospholipid bilayer was covered on the MSNs surface (MSN@Lip) as a liposomal cap that not only reduced drug leakage but also improved the stability of the colloidal system.

8p dianmotminh02 03-05-2024 3 1   Download

Ebook "Systems for drug delivery: Safety, animal, and microbial polysaccharides" details current developments in all natural polymers, with a focus on animal and microbial polysaccharides. The book examines, compares, and contrasts the efficiency of plant and algae based natural polymers in inducing immune reactions. Additionally, the book details the safety and toxicity profiles with respective regulations.

205p tracanhphuonghoa1007 22-04-2024 7 1   Download

Part 2 book "Aspen plus® - Chemical engineering applications" includes content: Heat exchanger (H.E.) design, electrolytes, polymerization processes, characterization of drug like molecules using aspen properties, solids handling, aspen plus® dynamics, safety and energy aspects of chemical processes, aspen process economic analyzer, term projects.

338p muasambanhan10 11-04-2024 4 1   Download

Ebook Boh’s pharmacy practice manual: A guide to the clinical experience (fourth edition) - Part 1 includes content: Patient safety, the law and the clinical practice of pharmacy, patient consultation in the cycle of patient care , providing drug information, physical examination, diagnostic procedures, drug administration,… and other contents.

377p longtimenosee03 01-02-2024 2 0   Download

Part 1 book "Drug induced oral complications" includes content: Adverse drug reactions, iatrogenic diseases, drug safety, and pharmacovigilance - Importance and interest for patients and their physicians; drug induced gingival overgrowth, drug induced oral mucosal pigmentation, drug induced oral ulcers, drug induced oral lichenoid reaction, medication related osteonecrosis of the jaws.

63p muasambanhan06 01-02-2024 2 1   Download

Ebook "Drug safety evaluation: Methods and protocols" provides up-to-date chapters and new chapters focusing on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation,...

425p lucchinguyen 28-12-2023 8 2   Download

Part 2 book "Toxicological effects of veterinary medicinal products in humans (Vol 1)" includes content: Veterinary products containing pesticide active ingredients, antineoplastic drugs, antimicrobial drugs, human safety of coccidiostats - a european perspective, organophosphorus veterinary medicines, organophosphorus veterinary medicines, antiparasitic drugs,... and other contents.

249p muasambanhan02 18-12-2023 1 0   Download

Part 1 book "Toxicological effects of veterinary medicinal products in humans (Vol 2)" includes content: Human safety of coccidiostats - A european perspective, organophosphorus veterinary medicines, antifungal drugs, antiparasitic drugs, some other pharmacologically active drugs.

263p muasambanhan02 18-12-2023 2 0   Download

Part 2 book "Toxicological effects of veterinary medicinal products in humans (Vol 2)" includes content: Human safety of veterinary vaccines, adverse drug reactions in humans – data from veterinary pharmacovigilance schemes, veterinary medicines and the environment, potential adverse microbiological effects of antimicrobials.

199p muasambanhan02 18-12-2023 6 0   Download

Part 1 book "Zoo animal and wildlife immobilization and anesthesia" includes content: Clinical pharmacology, monitoring, airway management, thermoregulation, oxygen therapy, analgesia, physical capture and restraint, zoo and wildlife CPR, field emergencies and complications, euthanasia, remote drug delivery, capture myopathy, human safety during wildlife capture, elasmobranchs and holocephalans, crocodilian capture and restraint,... and other contents.

464p muasambanhan02 18-12-2023 1 0   Download

Cancer chemotherapy indications for patients with poor performance status and advanced lung cancer are limited. Molecular targeted drugs, including epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, can be used in patients with poor performance status owing to their high efcacy and safety.

6p vileonardodavinci 23-12-2023 3 2   Download

People with drug-resistant epilepsy (DRE) are at high risk of sudden unexpected deaths and lower quality of life. Experiments showed thread embedding acupuncture (TEA) has a seizurereducing effect; however, data on DRE has been limited. This trial aimed to establish the efficacy and safety of TEA in people with DRE.

9p vikissinger 21-12-2023 2 2   Download

Cancer therapy has evolved from non-specific cytotoxic agents to a selective, mechanism-based approach that includes targeted agents and immunotherapy. Although the response to targeted therapies for unresectable hepatocellular carcinoma (HCC) is acceptable with the improved survival, the high tumor recurrence rate and drug-related side effects continue to be problematic.

8p vileonardodavinci 23-12-2023 9 4   Download