Rationale and protocol design of a phase II study of first-line osimertinib treatment for patients with poor performance status and EGFR mutation-positive non-small cell lung cancer (OPEN/TORG2040)

Taking ACTION to reduce pain: ACTION study rationale, design and protocol of a randomized trial of a proactive telephonebased coaching intervention for chronic musculoskeletal pain among African Americans

14 p | 11 | 3

A phase II study of the PI3K inhibitor copanlisib in combination with the antiCD20 monoclonal antibody rituximab for patients with marginal zone lymphoma: Treatment rationale and protocol design of the COUP-1 trial

8 p | 11 | 3

REALizing and improving management of stable COPD in China: A multi-center, prospective, observational study to realize the current situation of COPD patients in China (REAL) – rationale, study design, and protocol

8 p | 7 | 2

Rationale and design of “Hearts & Parks”: Study protocol for a pragmatic randomized clinical trial of an integrated cliniccommunity intervention to treat pediatric obesity

12 p | 12 | 2

A randomized phase II study of S-1 monotherapy versus cisplatin with vinorelbine for completely resected stage II/IIIA non-small cell lung cancer: Rationale and study protocol design for the LOGIK1702 study

6 p | 7 | 2

Rationale and design of REGULATE: An observational study protocol for relationship between plasma metabolome and the efficacy of systemic glucocorticoid in acute exacerbation of chronic obstructive pulmonary disease

6 p | 11 | 0