Drug sequestration

The roles and mechanisms involved in starvation-induced autophagy in mammalian cells have been extensively studied. However, less is known about the potential role for autophagy as a survival pathway in acquired drug resistance in cancer cells under nutrient-rich conditions.

18p vimale2711 25-08-2020 9 1   Download

Ovarian cancer is the most common fatal cancer of the female reproductive tract in industrialized countries. At the time of writing, it is the fourth most common cause of cancer death in women in the U.K., after breast, lung, and colorectal cancer, with a lifetime risk of approximately 2% (1). It tends to present at an advanced stage, with limited prospects for treatment and generally poor survival.

746p tom_123 15-11-2012 56 3   Download

Pharmacokinetic Interactions Causing Decreased Drug Effects Gastrointestinal absorption can be reduced if a drug interaction results in drug binding in the gut, as with aluminum-containing antacids, kaolin-pectin suspensions, or bile acid sequestrants. Drugs such as histamine H 2 receptor antagonists or proton pump inhibitors that alter gastric pH may decrease the solubility and hence absorption of weak bases such as ketoconazole.

5p tubreakdance 26-11-2010 82 3   Download