Drug synthesis

The past decade has seen a significant increase of research aimed at discovering new drugs for treating cancer, and the increasing number of new antineoplastic drugs approved by regulatory agencies reflects this. Until now, details on the synthesis of these newer agents have been scattered in various journals and in US and European patents.

230p vimeyers 29-05-2024 4 2   Download

This book focuses on different techniques of asymmetric synthesis of important compounds, such as drugs and natural products. It gives insightful information on recent asymmetric synthesis by Inorganic, Organic and Enzymatic combinations. It also emphasizes chiral compounds and design of new catalyst for synthesis of compounds.

509p vimeyers 29-05-2024 5 2   Download

In this research, a single-step polymeric novel particle was synthesized from oak bark extract by nanoemulsion polymerization technique for the first time in the literature. It has been shown that the synthesized particles are achieved without losing any antioxidant and antibacterial properties of the oak bark extract. In this study, the p(OB) particles were reported for the first time and were characterized in terms of antioxidant, blood compatible, H2O2 scavenging, antibacterial, and antifungal potential to evaluate their use in biocompatible materials with drug release system potential.

13p dianmotminh02 03-05-2024 3 1   Download

In this research paper we report the detailed synthesis, spectral (1H-NMR, FT-IR, and UV-Vis), crystal structure determination, DFT studies, and molecular modeling of 4-amino-3-mercapto-5-methyl-1,2,4-triazole (L2) Schiff base ligand and its complexes of cadmium as suitable bioactive agents for the treatment of malaria. From the spectroscopic results, the synthesized Schiff base has potentialtridentate coordination with themetal ion via hydroxy naphthalinic-O, azomethine-N and sulphur atom of the thione group.

17p dianmotminh02 03-05-2024 2 1   Download

The outcomes are to be compared with typical drugs given that compounds are examined against gram-positive and gram-negative strains of bacteria and fungus. Against bacterial strains, products with nitro, methyl, and bromo substituents in the p-position of the benzene ring, as well as products with the nitro group at the m-position, showed very excellent activities against bacterial strains, while compounds with chloro substituent at p-position and m-position demonstrated good activity against the fungal strains Aspergillus niger and Fusarium javanicum.

8p dianmotminh02 03-05-2024 2 1   Download

Alternating copolymers (ACs) contain two distinct monomeric unit types dispersed in alternating order of hydrophilic block and hydrophobic block. ACs have extensive and versatile applications in both academia and industry, especially in drug delivery systems (DDS) due to their unique physical and chemical properties. In the present research, poly(β-benzyl l-aspartate) (PBLA) was prepared by ring-opening polymerization of BLA-NCA. The result obtained from GPC showed that PBLA was successfully synthesized with narrow weight distribution Mw/Mn = 1.055. T

7p dianmotminh02 03-05-2024 2 1   Download

As a new work searching potential bioactive hybrid derivatives for drug design, where 3-aryl-2-mercaptoquinazolin-4(3H)-one scaffold is incorporated in specific coumarin moiety with or without bearing acetamide group, the synthesis and structure of new hybrid compounds were reported.

6p dianmotminh02 03-05-2024 2 1   Download

The melting points of the complexes were >350oC, indicating high thermal stability. Cu-Zn-containing complex showed the least binding energy against the three proteins. The bioactivity scores of the complexes were between -0.50 and 0.0. Against A549 Cu-Zn, Co-Zn and Fe-Zn containing complexes showed potential activity. Against MCF-7, Fe-Cu containing complex had IC50 of 53.5 whereas Co-Zn containing complex was active against HepG2. Three complexes were active against S. aureus in the tested range.

18p dianmotminh02 03-05-2024 2 1   Download

Carbon quantum dots (CQDs) are a new blooming carbon containing nanoparticles having size of less than 10 nm. They have wide range of application in the field of sensing of inorganic analytes, bio sensing, cell imaging, studying biological processes in living cells and also for drug delivery. T. In this review article we demonstrate how these tools are used to characterize newly synthesized CQDs, monitor the synthesis process along with finding its application in numerous fields.

26p dianmotminh02 03-05-2024 5 2   Download

Ebook "Synthesis of heterocycles in contemporary medicinal chemistry" is special in several aspects. First, it was composed by industrial medicinal and process chemists with decades of industrial experience. Secondly, it is dedicated to the heterocyclic drug compounds that have particularly marked the area of medicinal chemistry over the last decade.

281p tracanhphuonghoa1007 22-04-2024 7 3   Download

Ebook "Synthesis and characterization of glycosides (Second edition)" is a short and comprehensive study on the best known approaches for preparing the main types of glycosides. It covers synthetic pathways of challenging glycosides known as antiviral or antineoplastic drugs, and synthetic substrates used for enzymatic detection, including those used for detection of gene markers in plant biotechnology. The author pays special attention to the structural characterization of glycosides and provides the basic tools for the structural assignment through NMR, X-Ray and mass spectra techniques.

432p tracanhphuonghoa1007 22-04-2024 3 2   Download

Ebook "Functionalization of carborane via carboryne intermediates" focuses on the development of new methods of functionalizing carboranes using o-carboryne intermediates. Functional carboranes are now finding a broad range of applications, including organic synthesis, drug design, polymers, catalysis, metal−organic frameworks, electronic devices and more. However, the limited number of efficient synthetic methods for obtaining functional carborane materials has restricted their applications.

180p tudohanhtau1006 29-03-2024 2 1   Download

Ebook "Protein ligation and total synthesis II (Topics in Current chemistry, Volume 363)" presented in the following pages are authored by some of the pioneers and active researchers in the field from different countries. These chapters reflect many of the important issues in the area, namely, development of novel chemical methods for the ligation of peptide segments, total and semi-synthesis of important protein targets, and application of state-of-the-art methods to solve problems in biochemistry research or drug development.

235p tudohanhtau1006 29-03-2024 2 1   Download

Ebook "Chemistry of antibiotics and related drugs" builds on the success of the earlier edition, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections. Then it delves into the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels.

227p tudohanhtau1006 29-03-2024 5 1   Download

In this study, we introduce a novel method for effecting the direct difluoromethylation at the C-3 position of the quinoline ring. Comprehensive characterizations, including 1 H-NMR, 13C-NMR, and 19F-NMR for all compounds are performed. We believe that this novel method will open a new way to access the hitherto untapped C-3-difluoromethylation active compounds.

6p viellison 28-03-2024 3 2   Download

In ebook "Nucleic acid drugs (Advances in Polymer science, Volume 249)" the basic concept of antisense and siRNA strategies is summarized by Dr. Yano of Nippon Shinyaku Co. The antisense strategy can be regarded as the striking NAD concept that was logically innovated in the mid-1970s. Originally, oligonucleotides complementary to mRNAs were thought to physically block translational steps in gene expression resulting in the blocking of protein synthesis.

189p coduathanh1122 27-03-2024 1 1   Download

Part 1 book "Recent advances in novel drug carrier systems" includes content: Hot melt extrusion (hme) - from process to pharmaceutical applications; development and investigation of dry powder inhalers for cystic fibrosis; the role of carrier in dry powder inhaler nanotechnology in drug delivery, lipid nanoparticulate drug delivery systems - A revolution in dosage form design and development; niosomes as carrier in dermal drug delivery; magnetic nanoparticles - Synthesis, surface modifications and application in drug delivery; nanocarrier systems for transdermal drug delivery.

250p muasambanhan09 16-03-2024 4 1   Download

Part 2 book "Recent advances in novel drug carrier systems" includes content: Nanocarrier systems for transdermal drug delivery; oral delivery of insulin - novel approaches; novel mucoadhesive polymers for nasal drug delivery; amphiphilic cyclodextrins, synthesis, utilities and application of molecular modeling in their design; processing and templating of bioactive loaded polymeric neural architectures - challenges and innovative strategies; novel drug delivery systems for modulation of gastrointestinal transit time,... and other contents.

260p muasambanhan09 16-03-2024 7 1   Download

Ebook "Artemisia annua - Pharmacology and biotechnology" is an effective antimalarial agent, particularly for multi-drug resistant and cerebral malaria. However, the concentration of artemisinin in the plant is very low. Because the chemical synthesis of artemisinin is complicated and not economically feasible in view of the poor yield of the drug, the intact plant remains the only viable source of artemisinin production. Therefore, it is necessary to increase the concentration of artemisinin in A. annua to reduce the cost of artemisinin based antimalarial drugs.

288p manmanthanhla0201 26-02-2024 8 1   Download

Ebook "The double [3+2] photocycloaddition reaction" describes a novel, environmentally friendly photochemical step that converts in one pot, trivial starting materials into otherwise difficult to construct fenstrane frameworks. The rigid cores of these frameworks have significant potential in drug design. Moreover, the novelty of this work overtakes many other methods for the creation of chiral centres. No less than seven chiral centres are created in the photochemical step together with the formation of four carbon-carbon bonds and multifused rings.

191p manmanthanhla0201 26-02-2024 3 2   Download