Early identification
-
Breast cancer remains a significant health challenge worldwide, necessitating the identification of reliable biomarkers for early detection, accurate prognosis, and targeted therapy.
13p vikoch 27-06-2024 1 1 Download
-
Aggression in early childhood is considered to a common problem. Identification, reduction and prevention of aggression, especially in early childhood are also considered prevalent. Preschool teachers are known as one of the most important people in children’s lives as they are the first ones to meet the child after parents.
17p viarnault 25-04-2024 1 1 Download
-
Monitoring treatment and early detection of fatal breast cancer (BC) remains a major unmet need. Aberrant circulating DNA methylation (DNAme) patterns are likely to provide a highly specific cancer signal. We hypothesized that cell-free DNAme markers could indicate disseminated breast cancer, even in the presence of substantial quantities of background DNA.
11p vioraclene 31-03-2024 5 2 Download
-
Pancreatic cancer is an aggressive cancer with dismal prognosis, urgently necessitating better biomarkers to improve therapeutic options and early diagnosis. Traditional approaches of biomarker detection that consider only one aspect of the biological continuum like gene expression alone are limited in their scope and lack robustness in identifying the key regulators of the disease.
20p vioraclene 31-03-2024 7 1 Download
-
Multiple sclerosis is a chronic neuroinfammatory disease with a highly heterogeneous disease course. Preventing lasting disability requires early identification of persons at risk and novel approaches towards patient stratification for personalized treatment decisions. In this comment, we discuss the importance of large datasets of real-world cohorts in order to address this unmet need.
3p viellison 28-03-2024 4 2 Download
-
The article "Supply chain infrastructure development in Russian economy" is devoted to the study of the activities of Zemstvo institutions for the development of supply chain infrastructure in the XIX-early XX centuries; identification of the role of the Zemstvo reform in the formation of supply chain infrastructure at the local level. Supply Chain infrastructure provides the means for chain economic entities and firms sharing a common interest to participate in a mutual exchange.
7p longtimenosee04 06-03-2024 5 1 Download
-
The incidence of early-onset colorectal cancer (EOCRC; patients < 50 years old) has been rising rapidly, whereas the EOCRC genetic susceptibility remains incompletely investigated. Here, we aimed to systematically identify specific susceptible genetic variants for EOCRC.
19p vicwell 29-02-2024 4 1 Download
-
Early identification of genetic risk factors for complex diseases can enable timely interventions and prevent serious outcomes, including mortality. While the genetics underlying many Mendelian diseases have been elucidated, it is harder to predict risk for complex diseases arising from the combined effects of many genetic variants with smaller individual effects on disease aetiology.
13p vicwell 29-02-2024 5 2 Download
-
Early identification of axillary lymph node metastasis (ALNM) in breast cancer (BC) is still a clinical difficulty. There is still no good method to replace sentinel lymph node biopsy (SLNB). The purpose of our study was to develop and validate a nomogram to predict the probability of ALNM preoperatively based on ultrasonography (US) and clinicopathological features of primary tumors.
11p vileonardodavinci 23-12-2023 6 3 Download
-
Early detection of bladder cancer (BCa) offers patients a favorable outcome and avoids the need for cystectomy. Development of an accurate and sensitive noninvasive BCa diagnostic test is imperative. DNA methylation is an early epigenetic event in the development of BCa. The aim of this study was to identify methylation biomarkers for early detection of BCa.
9p vileonardodavinci 23-12-2023 6 3 Download
-
Overall survival (OS) is the gold standard to assess novel therapeutics to treat cancer. However, to identify early efficacy and speed up drug approval, trials have used progression-free survival (PFS) as a surrogate endpoint (SE). Herein, we aimed to examine if PFS could function as an OS surrogate in advanced Esophageal Squamous Cell Carcinoma (ESCC) treated with first-line immunochemotherapy.
13p vischultz 20-10-2023 3 1 Download
-
Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in women. Approximately 50% of breast cancers are discovered at an early stage in patients for whom conservative surgery is indicated. Intraoperative localization of non-palpable breast lesions is generally accomplished using a hook wire to mark the area of concern under ultrasound or stereotactic localization.
6p vioracle 29-09-2023 7 2 Download
-
We aimed to identify tumor-associated antigen (TAA) biomarkers through bioinformatic analysis and experimental verification, and to evaluate a panel of autoantibodies against tumor-associated antigens (TAAbs) for the detection of oral cancer (OC).
11p vioracle 29-09-2023 5 2 Download
-
Lung adenocarcinoma (LUAD) is an extraordinarily malignant tumor, with rapidly increasing morbidity and poor prognosis. Immunotherapy has emerged as a hopeful therapeutic modality for lung adenocarcinoma. Furthermore, a prognostic model (based on immune genes) can fulfill the purpose of early diagnosis and accurate prognostic prediction.
20p vioracle 29-09-2023 2 2 Download
-
Part 1 book "Management of acute coronary syndromes" includes content: The spectrum of myocardial ischemia; linking biochemistry, vascular biology, and clinical events in acute coronary syndromes; triggers of acute coronary syndromes emergency department presentations of acute cardiac ischemia; early identification and treatment of patients with acute coronary syndromes.
392p oursky02 06-08-2023 5 2 Download
-
Congenital absence of an internal carotid artery (ICA) is an extremely rare vascular anomaly. This case report presents an instance of right ICA agenesis to highlight the importance of early identification of this anomaly and its impact on disease presentation and complications.
5p viwhitewolf 03-07-2023 5 2 Download
-
To determine the effects of using unstructured clinical text in machine learning (ML) for prediction, early detection, and identification of sepsis. Materials and methods: PubMed, Scopus, ACM DL, dblp, and IEEE Xplore databases were searched. Articles utilizing clinical text for ML or natural language processing (NLP) to detect, identify, recognize, diagnose, or predict the onset, development, progress, or prognosis of systemic inflammatory response syndrome, sepsis, severe sepsis, or septic shock were included.
17p vighostrider 25-05-2023 9 2 Download
-
Accurate and rapid phenotyping is a prerequisite to leveraging electronic health records for biomedical research. While early phenotyping relied on rule-based algorithms curated by experts, machine learning (ML) approaches have emerged as an alternative to improve scalability across phenotypes and healthcare settings.
15p vighostrider 25-05-2023 5 2 Download
-
Maturity-onset diabetes of the young comprises a large group of autosomal inherited gene mutations. Maturity-onset diabetes of the young subtype 5 is caused by mutations in the HNF1B gene. This gene is expressed in the early phase of embryonic development in the pancreas, kidneys, liver, and genital tract; therefore, kidney or urinary tract malformations are associated with diabetes mellitus.
6p vidoctorstrange 06-05-2023 4 2 Download
-
The clinical presentations of each patient in this study are different from each other, demonstrating the intrafamilial phenotypic variability of this mutation. Early identification of the underlying genetic course of the disease by sequencing, combined with clinical findings provides solid evidence to diagnosis process, genetic counseling and management strategy.
9p vicaptainmarvel 21-04-2023 4 2 Download