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Enantiomer separations
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High-performance liquid chromatographic (HPLC) and subcritical fluid chromatographic (SFC) separations of the enantiomers of structurally diverse, basic ß-carboline, tetrahydroisoquinoline and benzazepine analogues of pharmacological interest were performed applying chiral stationary phases (CSPs) based on (i) neutral polysaccharides- and (ii) zwitterionic sulfonic acid derivatives of Cinchona alkaloids.
10p
viginny
23-12-2022
5
3
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Since decades, cyclodextrins are one of the most powerful selectors in chiral capillary electrophoresis for the enantioseparation of diverse organic compounds. This review concerns papers published over the last decade (from 2009 until nowadays), dealing with the capillary electrophoretic application of single isomer cyclodextrin derivatives in chiral separations.
30p
viginny
23-12-2022
7
3
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The enantioselective separation of newly prepared, pharmacologically significant isopulegol-based ßamino lactones and ß-amino amides has been studied by carrying out high-performance liquid chromatography on diverse amylose and cellulose tris-(phenylcarbamate)-based chiral stationary phases (CSPs).
10p
viginny
23-12-2022
9
3
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In the present study separation of enantiomers of some chiral neutral, basic and weakly acidic analytes was investigated on the chiral stationary phase (CSP) made by covalent immobilization of amylose tris(3-chloro-5-methylphenylcarbamate) onto aminopropylsilanized (APS) silica in nano-liquid chromatography (nano-LC) in aqueous methanol or acetonitrile mixtures.
8p
viginny
23-12-2022
7
3
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Novel Psychoactive Substances (NPS) represent an alternative to established illicit drugs. They are traded via the internet and exhibit small alterations in their chemical structure to circumvent law, however, their psychotropic effects are comparable. There is still poor knowledge about side effects and health risks.
15p
viginny
23-12-2022
5
3
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In this study, we present results obtained on the enantioseparation of some cationic compounds of pharmaceutical relevance, namely tetrahydro-ß-carboline and 1,2,3,4-tetrahydroisoquinoline analogs. In highperformance liquid chromatography, chiral stationary phases (CSPs) based on strong cation exchanger were employed using mixtures of methanol and acetonitrile or tetrahydrofuran as mobile phase systems with organic salt additives.
9p
viginny
23-12-2022
10
3
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The enantioseparation of four oxazolidinone and one biosimilar thiazolidine derivatives was performed on seven different polysaccharide-type chiral stationary phases (Lux Amylose-1, Lux i-Amylose-1, Lux Amylose-2, Lux Cellulose-1, Lux Cellulose-2, Lux Cellulose-3, Lux Cellulose-4) differing in backbone (cellulose or amylose), substituent or the immobilization technologies (coated or immobilized).
8p
viginny
23-12-2022
5
3
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Mục tiêu của đề tài là xây dựng quy trình chiết xuất ĐPĐQ của evodiamin và rutaecarpin trong quả Ngô thù du (NTD); thẩm định quy trình định lượng đồng thời ĐPĐQ của evodiamin và rutaecarpin bằng sắc ký lỏng hiệu năng cao (HPLC).
5p
closefriend02
07-10-2021
19
1
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(bq) part 2 book "chiral separation techniques" has contents: membranes in chiral.separations; enantiomer separations using designed imprinted chiral phases, enantiomer separations using designed imprinted chiral phases, nonchromatographic solid phase purification of enatiomers,...and other contents.
200p
bautroibinhyen20
06-03-2017
35
3
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Although the technologies on chiral/enantiomer separation and stereoselective analysis have matured in the past ca. 20 years, the development of new, even more advanced chiral separation materials, mechanisms and methods still belong to the more challenging tasks in separation science and analytical chemistry. An analysis of recent trends indicates that capillary electrophoresis (CE) can show real advantages over chromatographic methods in ultratrace chiral determination of biologically active ionogenic compounds in complex matrices, including mostly biological ones....
205p
maket1311
16-10-2012
42
7
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Chirality plays a major role in biological processes, and the enantiomers of a bioactive molecule often possess different biological effects. For example, all pharmacological activity may reside in one enantiomer of a molecule, or enantiomers may have identical qualitative and quantitative pharmacological activity. In some cases, enantiomers may have qualitatively similar pharmacological activity, but different quantitative potencies.
65p
bigbaby87
03-09-2010
85
15
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