Error profiles

Sequencing errors are key confounding factors for detecting low-frequency genetic variants that are important for cancer molecular diagnosis, treatment, and surveillance using deep next-generation sequencing (NGS). However, there is a lack of comprehensive understanding of errors introduced at various steps of a conventional NGS workflow, such as sample handling, library preparation, PCR enrichment, and sequencing. In this study, we use current NGS technology to systematically investigate these questions.

15p vigalileogalilei 27-02-2022 14 2   Download

The model accurately determines the uncut chip geometry, validated theoretically against a CAD representation of the chip with errors below 3%. Furthermore, a set of milling trials was proposed to compare the chip mass and the cutting forces estimated by the model with those measured from the trials in torus and spherical profiles.

19p guernsey 28-12-2021 14 0   Download

Failure and pitting of teeth of gear affects transmission error. So, aim of this study was to define optimal tooth modifications introduced by performing static contact and deformation analysis, while trying to design spur gears to resist failure and pitting of the teeth. Behaviour of unusual contact between flywheel ring gear and starter motor pinion was analysed and optimized root fillet was introduced in spur gear.

12p chauchaungayxua10 19-03-2021 12 1   Download

Previous studies have suggested that distinct and homogenous sub-groups of gait patterns exist among runners with patellofemoral pain (PFP), based on gait analysis. However, acquisition of 3D kinematic data using optical systems is time consuming and prone to marker placement errors.

10p vitennessee2711 01-02-2021 8 1   Download

Illumina’s sequencing platforms are currently the most utilised sequencing systems worldwide. The technology has rapidly evolved over recent years and provides high throughput at low costs with increasing read-lengths and true paired-end reads.

15p vioklahoma2711 19-11-2020 18 1   Download

Next-generation sequencing has been used by investigators to address a diverse range of biological problems through, for example, polymorphism and mutation discovery and microRNA profiling. However, compared to conventional sequencing, the error rates for next-generation sequencing are often higher, which impacts the downstream genomic analysis.

11p vioklahoma2711 19-11-2020 13 2   Download

Some applications, especially those clinical applications requiring high accuracy of sequencing data, usually have to face the troubles caused by unavoidable sequencing errors. Several tools have been proposed to profile the sequencing quality, but few of them can quantify or correct the sequencing errors.

10p vioklahoma2711 19-11-2020 7 0   Download

Molecular profiles change in response to perturbations. These changes are coordinated into functional modules via regulatory interactions. The genes and their products within a functional module are expected to be differentially expressed in a manner coherent with their regulatory network.

14p vicoachella2711 27-10-2020 10 1   Download

Platform-specific error profiles necessitate confirmatory studies where predictions made on data generated using one technology are additionally verified by processing the same samples on an orthogonal technology. However, verifying all predictions can be costly and redundant, and testing a subset of findings is often used to estimate the true error profile.

11p viconnecticut2711 28-10-2020 15 0   Download

The Nigerian economy in the last two decades up until 2013 has been growing at an average of 6% and yet unemployment was equally growing in the region of 20% within the same period. This paradoxical situation has led to a flurry of studies and postulations aimed at providing explanation and solution to the phenomenon. This study making use of a regression model with annual data from 1980 to 2013, empirically determined the impact of public sector expenditures (CEXP and REXP) together with private sector investment (PINV) on unemployment (UNEMP) in Nigeria.

9p chauchaungayxua2 09-01-2020 30 1   Download

A new fast least-squares method is developed to estimate the shape factor (q-parameter) of a buried structure using normalized residual anomalies obtained from gravity data. The problem of shape factor estimation is transformed into a problem of finding a solution of a non-linear equation of the form f(q) = 0 by defining the anomaly value at the origin and at different points on the profile (N-value). Procedures are also formulated to estimate the depth (z-parameter) and the amplitude coefficient (A-parameter) of the buried structure.

9p kethamoi1 17-11-2019 14 0   Download

The atmospheric molecule density profile is directly derived from the correction-range lidar signal. The temperature profile is deduced from the molecular density profile based on the assumptions of the hydrostatic equilibrium and the ideal-gas law. Lidar measurements show good agreement with the molecular density and the temperature profiles from the MSISE-90 atmospheric model. Maximum errors of the density and temperature are found to be ±0.9% and ±3.4 K, respectively. The position and the temperature of the stratopause in Hanoi are determined to be about 49 km and 270 K.

10p thuyliebe 09-10-2018 33 0   Download

This paper presents a method of real-time CNC interpolation for complex curved profiles which can be described with NURBS equations. The real-time interpolation algorithm is based on second order Taylor’s expansion with the principle part being a formula for updating parametric value u after each sampling period.

8p cumeo3000 01-08-2018 41 0   Download

Supporters of credit scoring note that credit scores have statistical validity, and are predictive of repayment behavior for large populations. However, this does not mean that credit data are error free, nor that credit scoring models are perfect predictors of individual creditworthiness; it only means that they work on average. While the systems do present an accurate risk profile of a large numbers of consumers, data users who manage large numbers of accounts priced by credit risk have a greater tolerance for errors in credit scoring systems than consumers do.

44p enterroi 01-02-2013 85 4   Download

Over the past eight years the Board has introduced many new technology applications to streamline Board administrative processes, reduce data error, and provide more and better information to consumers. The first of these was Physician Profiles. In 2004 the Division reached another major milestone when it migrated Board data from several antiquated and incompatible database systems into a new, consolidated database called CLARIS. Access to Board data is now possible from a single system, improving efficiency, expanding the potential for cogent data analysis and reducing errors.

0p quaivatdo 17-11-2012 54 1   Download

Users, Registration, and Authentication If they have submitted the form, we check the registration, to see if the values are valid: if( $this-checkRegistration() == true ) { If the form was completed properly, we can then process the registration and create the user account and the profile: $userId = $this-processRegistration(); if( $this-activeValue == 1 ) { If we have set all users to be active by default, we log the user in automatically: $this-registry-getObject('authenticate')forceLogin( $this-submittedValues['register_ user'], md5( $this-submittedValues['register_ password'] ) ); }...

10p yukogaru13 30-11-2010 74 9   Download

Profiles and Statuses require_once( FRAMEWORK_PATH . 'controllers/profile/ profilestatusescontroller.php' ); $sc = new Profilestatusescontroller( $this-registry, true, $user ); } If the user tried to access a sub-controller that doesn't exist, we would display an error.

10p yukogaru10 31-10-2010 107 6   Download

can be done on a test rig out in the main works or sometimes even on the equipment while running normally. However, the basic idea is that pitch, profile and helix errors may combine with tooth bending, gear body distortions and whole gear body deflections to give an overall relative deflection (from smooth running) at the meshpoint between the gears. It is also difficult to convince gear engineers that there is a very big difference between roll (double flank) checking, which is extremely cheap and easy, and T.E. (single flank) checking since they give rather similar looking results.

20p hiruscar 13-10-2010 75 10   Download