Essential role

Cytokines play an essential role in the pathogenesis related to the severity, monitor progress, and evaluate ICS therapeutic response in asthma. Research objectives: Evaluate changes in serum levels of IL4, IL5, IL13, and TNFα in patients with asthma control according to GINA after 3 months.

9p viengfa 28-10-2024 2 1   Download

Vibrio parahaemolyticus is one of the dangerous pathogens of aquatic animals, including fish. The outer membrane proteins play an essential role in bacterial virulence and are potential candidates for vaccine development. In this study, the virulence of four V. parahaemolyticus strains was studied, and the result was that strain. The V. parahaemolyticus N9 has the strongest virulence with an LD50 of 106.15 CFU/mL.

8p viinuzuka 28-02-2025 6 1   Download

Public speaking is recognized as one of the most essential skills in the 21st century, playing a crucial role in assessing students’ speaking abilities and overall communication competence. This is especially important for EFL university students, who face significant challenges in mastering public speaking. This study aims to investigate the causes of public speaking anxiety and examine the effects of workshops on improving students' public speaking skills.

9p vihyuga 20-02-2025 2 1   Download

Thyroid carcinomas are the most common endocrine malignancies. The cervical lymph node metastasis rate in patients with PTC ranges from 30-80% and there is a significant difference in survival at 14 years for those with and without lymph node metastases. Therefore, the early detection of metastatic cervical lymph nodes plays an essential role in deciding upon the optimal surgical treatment plan for the majority of patients, which will allow careful postoperative screening, adjuvant therapies, and minimizes the chance of disease recurrence, so we conducted this study.

6p vinara 11-01-2025 4 1   Download

Obesity is well known that in various human pathological states such as: essential hypertension, coronary heart disease, type 2 diabetes mellitus,... Insulin resistance plays an important role in pathological state of diabetes. Recently, Katz et al provided QUICKI index (Quantitative insulin sensitivity check index) for insulin resistance condition evaluation. We carried out this study to determine the prevalence of insulin resistance by the QUICKI index and to evaluate the correlation between QUICKI index and the fasting glucose, insulin concentration.

4p viuchiha 06-01-2025 3 1   Download

Time series analysis is an essential field in data analysis, particularly within forecasting and prediction domains. Researching and building time series models play a crucial role in understanding and predicting the temporal dynamics of various phenomena. In mathematics, time series data is defined as data points indexed in chronological order and have a consistent time interval between consecutive observations.

10p vibenya 31-12-2024 5 2   Download

Chapter 10 - Discipline and employee assistance programs. This chapter presents the following content: Essentials of discipline, approaches to discipline, administering discipline, termination, special disciplinary concerns, they supervisor’s key role.

23p trueorfalse8 07-09-2017 41 3   Download

This study begins with the desire to better understand the construction of university reputation. The framework of university reputation and student behavioral intention is formed by the relationship between student trust, student identity, and student commitment. Vietnam's higher education sector plays an essential role in education; this sector has been encountering various problems, and university reputation is a key pillar in educational management theory.

201p nguathienthan10 23-02-2021 22 4   Download

The essential role of the disciplinary sanctions is similar to that of the criminal sanctions and consists in the future prevention of facts that could affect the labor relations, which result from the individual employment contract concluded between the employer and the employee according to the law.

7p christabelhuynh 04-06-2020 20 4   Download

Geo-electrical tomographical software plays a crucial role in geophysical research. However, imported software is expensive and does not provide much customizability, which is essential for more advanced geophysical study. Besides, these programs are unable to exploit the full potential of modern hardware, so the running time is inadequate for large-scale geophysical surveys. It is therefore an essential task to develop domestic software for overcoming all these problems.

60p 01202750693 09-06-2015 66 13   Download

The Sp family is a family of transcription factors that bind to cis-elements in the promoter regions of various genes. Regulation of transcription by Sp proteins is based on interactions between a GC-rich binding site (GGGCGG) in DNA and C-terminal zinc finger motifs in the proteins. In this study, we characterized the GC-rich promoter of the gene for the DNA methyltransferase (Dnmt1) that is responsible for methylation of cytosine residues in mammals and plays a role in gene silencing.

10p system191 01-06-2013 41 4   Download

Chromatin is a highly dynamic structure that plays an essential role in regulating all nuclear processes that utilize the DNA template including DNA repair, replication, transcription and recombination. Thus, the mechanisms by which chromatin structures are assembled and modified are questions of broad interest. This minireview will focus on two groups of proteins: (a) histone chaperones and (b) ATPdependent chromatin remodeling machines, that co-operate to assemble DNA and histone proteins into chromatin....

7p research12 01-06-2013 37 4   Download

Duodenase is a 29-kDa serine endopeptidase that displays selective trypsin- and chymotrypsin-like substrate specificity. This enzyme has been localized to epitheliocytes of Brunner’s glands, and as described here, to mast cells within the intestinal mucosa and lungworm-infected lung, implying an important additional role in inflammation and tissue remodelling. In primary cultures of pulmonary artery fibroblasts, duodenase induced a concentration-dependent increase in [3H]thymidine incorporation with a maximal effect observed at 30 nM.

10p research12 01-06-2013 57 3   Download

Stress-activated protein kinase (SAPK) signaling plays essential roles in eliciting adequate cellular responses to stresses and proinflammatory cytokines. SAPK pathways are composed of three successive protein kinase reactions. The phosphorylation of SAPK signaling components on Ser/Thr or Thr/Tyr residues suggests the involvement of various protein phosphatases in the negative regulation of these systems.

7p research12 01-06-2013 56 4   Download

The core complex ofRhodobacter sphaeroidesis formed by the association of the light-harvesting antenna 1 (LH1) and the reaction center (RC). The PufX protein is essential for photosynthetic growth; it is locatedwithin the core in a 1 : 1 stoichiometry with the RC. PufX is required for a fast ubiquinol exchange between the QBsite of the RC and the Qo site of the cytochromebc1complex.

9p research12 23-04-2013 36 3   Download

There is much evidence to indicate that cholesterol forms lateral membranemicrodomains (rafts), and to suggest their important role in cellular signaling. However, no probe has been produced to analyze cholesterol behavior, especially cholesterol movement in rafts, in real time. To obtain a potent tool for analyzing cholesterol dynamics in rafts, we prepared and characterized several truncated fragments of h-toxin (perfringolysin O), a cholesterol-binding cytolysin, whose chemicallymodified formhas been recently shown to bind selectively to rafts. ...

9p tumor12 22-04-2013 41 5   Download

The N-terminal domain (NTD) and the ligand-binding domain (LBD) of the androgen receptor (AR) exhibit a ligand–dependent interaction (N/Cinteraction). Amino acids 3–36 in theNTD(AR3)36) play a dominant role in this interaction. Previously, it has been shown that a FxxFF motif inAR3)36 , 23 FxxLF 27 , is essential forLBDinteraction. We demonstrate in the current study that AR3)36 can be subdivided into two functionally distinct fragments: AR3)13 andAR16)36.AR3)13does not directly interact with the AR LBD, but rather contributes to the transactivation function of theAR.NTD-AR.LBDcomplex....

12p tumor12 22-04-2013 34 2   Download

The presence of extraN- andC- terminal residues can play a major role in the stability, solubility and yield of recombi-nant proteins. Pfg27 is a 27Ksoluble protein that is essential for sexual development in Plasmodium falciparum.It was over-expressed using the pMAL-p2 vector as a fusion pro-teinwith themaltosebindingprotein. Sixdifferent constructs were made and each of the fusion proteins were expressed and purified.

5p tumor12 22-04-2013 41 2   Download

Met53 in barleya-amylase 1 (AMY1) is situated at the high-affinity subsite)2. While Met53 is unique to planta-amy-lases,the adjacent Tyr52 stacks onto substrate at subsite)1 and is essentially invariant in glycoside hydrolase family 13. These residues belong toa short sequencemotif inbfialoop 2 of the catalytic (b/a)8-barrel and site-directedmutagenesis was used to introduce a representative variety of structural changes,Met53Glu/Ala/Ser/Gly/Asp/Tyr/Trp,to investi-gate the role of Met53.

14p tumor12 22-04-2013 44 4   Download

Four pyruvate dehydrogenase kinase and two pyruvate dehydrogenase phosphatase isoforms function in adjusting the activation state of the pyruvate dehydrogenase complex (PDC) through determining the fraction of active (non-phosphorylated) pyruvate dehydrogenase component. Necessary adaptations of PDC activity with varying meta-bolic requirements in different tissues and cell types are met by the selective expression and pronounced variation in the inherent functional properties and effector sensitivities of these regulatory enzymes. ...

7p tumor12 20-04-2013 33 2   Download