Flavones and isoflavones

The reliability of Quantitative Structure – Activity or Property Relationships for prediction of physico-chemical properties and anticancer activity of flavone and isoflavone derivatives was improved by using the quantitative relationships between structurally similar flavone and isoflavone structures (QSSRs). The targeted-compound method was developed by a training set, which contains only similar compounds structurally to target compound.

7p nguathienthan1 20-11-2019 22 2   Download

A new enzyme,S-adenosyl-L-methionine:flavonoid 4¢-O-methyltransferase (EC 2.1.1.-)(F 4¢-OMT), has been puri-fied 1 399-fold from the tissues of carnation (Dianthus caryophyllus L). The enzyme, with a molecular mass of 43–45 kDa and a pI of 4.15, specifically methylates the hydroxysubstituent in4¢-positionof theflavones, flavanones and isoflavones in the presence ofS-adenosyl-L-methionine. A high affinity for the flavone kaempferol was observed (Km¼1.7lM;Vmax¼95.2lmolÆmin )1 Æmg )1 ), while other 4¢-hydroxylated flavonoids proved likewise to be suitable substrates....

10p tumor12 20-04-2013 42 2   Download