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Folinic acid
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Chemoradiotherapy (CRT) remains the standard treatment for locally advanced rectal cancer (LARC). This phase 2 clinical trial was designed to evaluate the efficacy and safety of neoadjuvant triplet chemotherapy with mFOLFOXIRI (folinic acid, 5-fluorouracil, oxaliplatin, and irinotecan) in LARC.
11p
vioracle
29-09-2023
10
3
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Five-fluorouracil, folinic acid, oxaliplatin and irinotecan (FOLFOXIRI) regimen is used as the first-line treatment for metastatic colorectal cancer (mCRC). The use of capecitabine, an oral fluoropyrimidine pro-drug, is feasible and safe; hence, it provides an interesting alternative to 5-fluorouracil in the abovementioned regimen.
12p
viangelamerkel
27-07-2022
8
1
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Đậu biếc (Clitoria ternatea L.) là loài cây địa phương được trồng nhiều ở các nước có khí hậu nhiệt đới, nóng ẩm nằm trong khu vực Đông Nam Á. Trong hoa Đậu biếc có chứa nhiều nhóm hợp chất tự nhiên như: Flavonoid, polyphenol, anthocyanin, mome inositol, pentanal, cyclohexen, acid acetic... Mục tiêu của nghiên cứu nhằm định lượng polyphenol, flavonoid, khảo sát hoạt tích ức chế tế bào ung thư gan và ung thư vú, hoạt tính chống oxy hóa của các cao chiết từ hoa Đậu biếc.
14p
vipatriciawoertz
02-06-2022
26
2
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Produced from leaves of Camellia sinensis L. (Kuntz), tea is among the most common beverages worldwide. Tea plants have been grown in nearly 30 countries. In this study, the FolinCiocalteu method was applied to determine the total polyphenol contents (referred to milligrams gallic acid mass equivalence or GAE) in tea products (one oolong and three ancient teas, including red, green, and white) based on ISO 14502-1:2005 with some modifications, typically ultrasonicassisted single extraction using methanol:water (7:3 v/v) as an extraction solvent at 70oC with the extraction ratio of 0.200:10.
13p
viericschmid
12-01-2022
11
0
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According to the NAPOLI-1 trial, nanoliposomal irinotecan (nal-IRI) plus fluorouracil/folinic acid (5-FU/ LV) showed improved overall survival compared to fluorouracil alone for patients with metastatic pancreatic cancer who were previously treated with gemcitabine-based therapy. In that trial, Asian patients had frequent dose modification due to haematological toxicity.
9p
vimahuateng
26-11-2021
8
0
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According to current guidelines, treatment of patients with hepatic oligometastasis in pancreatic cancer is not reflected and systemic chemotherapy is recommended in those patients. Retrospective data suggest beneficial outcomes in patients with hepatic oligometastasis, though prospective data from clinical trials addressing this particular patient group is not available.
11p
vimahuateng
26-11-2021
10
1
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In this study, methanol extracts (MEs) and essential oil (EO) of Angelica purpurascens (Avé-Lall.
11p
tudichquannguyet
29-11-2021
3
0
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Preoperative chemoradiotherapy (CRT), the current standard of care for locally advanced rectal cancer (LARC), is associated with many radiotherapy (RT)-related side effects. We aimed to evaluate whether S-1 and oxaliplatin (SOX) or folinic acid, 5-FU, and oxaliplatin (mFOLFOX6) can be as effective as neoadjuvant chemotherapy (NAC) regimens for LARC without RT.
9p
vianrose2711
27-04-2021
7
1
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Polymorphisms of genes encoding the Fcy receptors (Fc fragment of IgG receptor 2A (FCGR2A) and 3A (FCGR3A)), which influence their affinity for the Fc fragment, have been linked to the pharmacodynamics of monoclonal antibodies.
9p
virose2711
24-09-2020
7
1
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Colorectal cancer (CRC) is the second most common malignancy in Europe and a leading cause of cancer-related death. Almost 50% of patients with CRC develop liver metastases, which heralds a poor prognosis unless metastases can be downsized to surgical resection or ablation.
7p
virose2711
22-09-2020
19
2
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The FOLFOXIRI regimen (irinotecan, oxaliplatin, fluorouracil [5-FU] and folinic acid [FA]) increased the response rate and overall survival compared to FOLFIRI in patients with metastatic colorectal cancer (mCRC). Adding cetuximab to FOLFOX or FOLFIRI increased efficacy in patients with k-ras wild type mCRC.
8p
vilisa271
22-09-2020
11
0
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Colorectal carcinoma is a common cause of cancer. Adjuvant treatments include: 5-fluorouracil administered together with folinic acid, or more recently, oral fluoropyrimidines such as capecitabine, in combination with oxaliplatin or irinotecan.
16p
vialabama2711
21-09-2020
12
0
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Often curative treatment for locally advanced resectable esophageal or gastro-esophageal junctional cancer consists of concurrent neoadjuvant radiotherapy and chemotherapy followed by surgery. Currently, one of the most commonly used chemotherapy regimens in this setting is a combination of a fluoropyrimidin and of a platinum analogue.
7p
vinaypyidaw2711
26-08-2020
12
1
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The FOLFOX regimen, i.e., folinic acid (FOL), fluorouracil (F) and oxaliplatin (OX), is a drug cocktail that is used to treat gastric and colorectal cancers. Despite the concomitant improvements in response rate, duration of response and patient survival, reports of serious toxic pulmonary side effects have progressively emerged.
11p
vidhaka2711
31-07-2020
13
1
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5-Fluorouracil (5FU), Folinic acid (FA), and Oxaliplatin (FOLFOX) or 5FU, FA, and Irinotecan (FOLFIRI) are standard regimens for palliative chemotherapy of metastatic colon cancer.
9p
vibaku2711
22-07-2020
12
2
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The present study was aimed to evaluate the bioactive phytochemical constituents of Adina cordifolia leaves, with this broad objectives the total phenolic contents (TPC), total flavonoid contents (TFC), total antioxidant potential and GC-MS analysis of leaf extracts were carried out. For the identification of medicinally important compounds in Adina cordifolia leaf, extracts were prepared using cold extraction method in different solvents of varying polarities viz., chloroform, ethyl acetate, acetone and methanol.
13p
gaocaolon5
14-06-2020
7
1
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Methotrexate is an important component in many chemotherapy protocols. The blood concentration of Methotrexate is used to determine the regimen of folinic acid. However, the lower limit of Siemens assay kit is 0.30 μmol/L in China.
7p
vimax2711
30-03-2020
6
1
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Từ lâu, dược liệu Cốt khí củ đã được sử dụng chữa tê thấp, do bị ngã, bị thương, kinh nguyệt bế tắc; ngoài ra nó còn là một vị thuốc thu liễm, cầm máu. Hiện nay, một trong những hướng phát triển là chứng minh tác dụng của cao toàn phần, cao phân đoạn và hoạt chất tinh khiết của dược liệu bằng những mô hình thử nghiệm với các trang thiết bị hiện đại để có kết luận khoa học. Do vậy, đề tài được thực hiện nhằm khảo sát tác dụng chống oxy hóa của cao toàn phần và các cao phân đoạn Cốt khí củ, từ đó xây dựng và thẩm định qui trình định lượng phenolic tổng của cao chiết có tác dụng chống oxy hóa.
5p
cothumenhmong2
06-02-2020
93
1
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This in-vitro study evaluates the antibacterial &antifungal action of aqueous & alcoholic extracts of new herbal vaginal formulation containing equal amounts of Symplocos racemosa Roxb. and Ficus glomerata Roxb. stem barks against gram positive and gram negative bacteria and candid fungus by using the methods of zone of inhibition and minimum inhibition concentration (MIC) to assess its efficacy in treating vaginitis. During phytochemical analysis, alkaloids, flavonoids, tannins and carbohydrates were found to be present in both extracts.
11p
kethamoi2
15-12-2019
12
0
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Bài viết trình bày đánh giá hiệu quả của phác đồ Methotrexate/Folinic Acid, trong điều trị bệnh cảnh tân sinh nguyên bào nuôi nguy cơ thấp, ở bệnh nhân hậu thai trứng (TT) tại Bệnh viện Từ Dũ.
6p
viachilles2711
10-10-2019
40
1
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