Follicular lymphoma
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Relapsed or refractory follicular lymphoma (rrFL) is an incurable disease associated with shorter remissions and survival after each line of standard therapy. Many promising novel, chemotherapy-free therapies are in development, but few are licensed as their role in current treatment pathways is poorly defined.
13p vishanshan 27-06-2024 1 1 Download
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Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity. Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to the mutations found in RNA sequencing of the cells.
16p vibransone 28-03-2024 2 1 Download
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Patients with follicular lymphoma (FL) can have high response rates to early lines of treatment. However, among FL patients relapsed/refractory (r/r) after ≥2 prior lines of therapy (LOT), remission tends to be shorter and there is limited treatment guidance. This study sought to evaluate the clinical outcomes for r/r FL after ≥2 prior LOT identified through systematic literature review.
12p vischultz 20-10-2023 6 1 Download
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Ovarian lymphoma is an uncommon malignancy with the incidence of primary ovarian lymphoma being ever rarer. Majority of patients with ovarian lymphoma tend to present with symptoms of abdominal distension, abdominal pain, loss of weight or appetite, and are usually found to have an ovarian mass.
5p viintuit 26-09-2023 2 0 Download
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The phosphoinositide 3- kinase (PI3K) pathway is involved in the growth of various human cancers, including lymphoid malignancies. However its role in the pathogenesis of follicular lymphoma (FL) has not been yet described.
9p vilisa271 22-09-2020 13 0 Download
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Morphology of Lymphomas: Describe the histologic appearance of typical cases of follicular lymphoma, diffuse large B-cell lymphoma, small lymphocytic lymphoma/ chronic lymphocytic leukemia, and Hodgkin lymphoma.
7p caothientrangnguyen 10-05-2020 11 1 Download
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part 2 book “handbook of hematologic malignancies” has contents: multiple myeloma, hodgkin lymphoma, immunoglobulin light chain amyloidosis, burkitt lymphoma, double hit lymphoma, mantle cell lymphoma, primary central nervous system lymphoma, follicular lymphoma, marginal zone lymphoma,… and other contents.
228p tieu_vu14 15-08-2018 33 1 Download
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Radioimmunotherapy consolidation and rituximab maintenance in the initial treatment of follicular lymphoma
3p dauphong12 08-02-2012 35 4 Download
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài:New targets for the treatment of follicular lymphoma
14p toshiba24 06-12-2011 65 6 Download
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: R-CHOP versus R-CVP in the treatment of follicular lymphoma: a meta-analysis and critical appraisal of current literature
7p toshiba24 06-12-2011 46 3 Download
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: FCR (Fludarabine, Cyclophosphamide, Rituximab) regimen followed by 90yttrium ibritumomab tiuxetan consolidation for the treatment of relapsed grades 1 and 2 follicular lymphoma: a report of 9 cases
5p toshiba22 21-11-2011 56 3 Download
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A rare combination of an endocrine tumour of the common bile duct and a follicular lymphoma of the ampulla of Vater: a case report and review of the literature
4p hoami_238 11-10-2011 70 2 Download
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Zelapar trị Parkinson, dùng chung với ledopa/carbidopa, - Hycamtin với Cistaplin trị ung thư tử cung giai đoạn IV-B, - Fluoroxetine trị bệnh Anorexia nervosa (biếng ăn tâm thần), - FDA bỏ Canasa 500mg nhưng vẫn cho dùng thuốc nhét Canasa 1000mg, Nexavar trong việc điều trị ung thư gan di căn, Nexavar cũng cho dùng điều trị ung thư thận trầm trọng, - Myvax chữa ung thư máu trong việc điều trị miễn dịch ung thư máu Follicular non-Hogkin lymphoma. - Ngoài ra FDA cũng cho phép thử nghiệm Panitumumab trong việc dùng kháng thể tạo sinh từ...
4p nganluong111 14-04-2011 50 3 Download
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Evaluation of an adequate biopsy by an expert hematopathologist is sufficient to make a diagnosis of follicular lymphoma. The tumor is composed of small cleaved and large cells in varying proportions organized in a follicular pattern of growth (Fig. 105-7). Confirmation of B cell immunophenotype and the existence of the t(14;18) and abnormal expression of BCL-2 protein are confirmatory. The major differential diagnosis is between lymphoma and reactive follicular hyperplasia. The coexistence of diffuse large B cell lymphoma must be considered.
5p thanhongan 07-12-2010 70 3 Download
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Patients with follicular lymphoma have a high rate of histologic transformation to diffuse large B cell lymphoma (5–7% per year). This is recognized ~40% of the time during the course of the illness by repeat biopsy and is present in almost all patients at autopsy. This transformation is usually heralded by rapid growth of lymph nodes—often localized—and the development of systemic symptoms such as fevers, sweats, and weight loss.
5p thanhongan 07-12-2010 71 3 Download
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Table 105-6 presents the best documented translocations and associated oncogenes for various subtypes of lymphoid malignancies. In some cases, such as the association of the t(14;18) in follicular lymphoma, the t(2;5) in anaplastic large T/null cell lymphoma, the t(8;14) in Burkitt's lymphoma, and the t(11;14) in mantle cell lymphoma, the great majority of tumors in patients with these diagnoses display these abnormalities. In other types of lymphoma where a minority of the patients have tumors expressing specific genetic abnormalities, the defects may have prognostic significance.
5p thanhongan 07-12-2010 89 3 Download
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The incidence of non-Hodgkin's lymphomas and the patterns of expression of the various subtypes differ geographically. T cell lymphomas are more common in Asia than in western countries, while certain subtypes of B cell lymphomas such as follicular lymphoma are more common in western countries. A specific subtype of non-Hodgkin's lymphoma known as the angiocentric nasal T/natural killer (NK) cell lymphoma has a striking geographic occurrence, being most frequent in Southern Asia and parts of Latin America.
5p thanhongan 07-12-2010 62 3 Download
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Table 79-3 Representative Oncogenes at Chromosomal Translocations Gene (Chromosome) Translocation Malignancy ABL BCR (22q11) (9q34.1)– (9;22)(q34;q11) Chronic myelogenous leukemia ATF1 EWS (22q12) (12q13)– (12;22)(q13;q12) Malignant melanoma of soft parts (MMSP) BCL1 IgH (14q32) (11q13.3)– (11;14)(q13;q32) Mantle lymphoma cell BCL2 IgH (14q32) (18q21.
5p konheokonmummim 03-12-2010 66 3 Download