Functional linear motifs

Animal genomes contain thousands of long noncoding RNA (lncRNA) genes, a growing subset of which are thought to be functionally important. This functionality is often mediated by short sequence elements scattered throughout the RNA sequence that correspond to binding sites for small RNAs and RNA binding proteins.

31p viarchimedes 26-01-2022 21 0   Download

Short linear protein motifs are attracting increasing attention as functionally independent sites, typically 3–10 amino acids in length that are enriched in disordered regions of proteins. Multiple methods have recently been proposed to discover over-represented motifs within a set of proteins based on simple regular expressions.

9p viwyoming2711 16-12-2020 9 0   Download

Analyzing the amino acid sequence of an intrinsically disordered protein (IDP) in an evolutionary context can yield novel insights on the functional role of disordered regions and sequence element(s).

9p vikentucky2711 24-11-2020 9 1   Download

Short linear motifs in host organisms proteins can be mimicked by viruses to create protein-protein interactions that disable or control metabolic pathways. Given that viral linear motif instances of host motif regular expressions can be found by chance, it is necessary to develop filtering methods of functional linear motifs.

11p vioklahoma2711 19-11-2020 10 1   Download

The United Nations Conference on Environment and Develop ment in Rio launched many important initiatives – Agenda 21, the Convention on Climate Change, and the Convention on Biological Diversity (CBD)

78p ranchoctdt7 16-07-2013 80 6   Download

This study uses what Cresswell (2003) refers to as a ‘mixed methods approach’, one that combines quantitative and qualitative data collection and a ‘sequential explanatory strategy’ in which the collection and analysis of the quantitative data is followed by the collection and analysis of the qualitative data (p 215).

449p dambaotaikhoan 04-05-2013 163 69   Download

It is promising, however, that a a majority of male and female respondents perceive social media as an enabler for women’s empowerment. This is coupled with the robust growth of social media usage among youth in the Arab region. If lessons are to be drawn from youth utilization of social media during the recent popular movements in the Arab world, then in light of the growing sense of empowerment today, the strong positive perceptions shown in our survey suggest that social media can continue to play an important role in empowering Arab women in the future. However, this will only...

71p thamgiacongdong 02-05-2013 52 7   Download

The process of producing the yearly updates began with a Pub Med search using search fields established by the Committee: 1) asthma, All Fields, All ages, only items with abstracts, Clinical Trial, Human, sorted by Authors; and 2) asthma AND systematic, All fields, ALL ages, only items with abstracts, Human, sorted by Author. In addition, peer-reviewed publications not captured by Pub Med could be submitted to individual members of the Committee providing an abstract and the full paper were submitted in (or translated into) English.

0p dacotaikhoan 26-04-2013 35 3   Download

In bringing together the results of the presentations highlighted in this paper, it becomes clear that aesthetic and artistic activities typically involve a network of brain regions distributed over both hemispheres, rather than a specialized area.

12p giamdocamnhac 06-04-2013 52 2   Download

This paper describes the compilation of the first truly comprehensive historical public debt database (HPDD) covering gross government debt-to-GDP ratios for nearly the entire country membership of the IMF and spanning a long time period. The HPDD covers 174 countries and starts from 1880 for most G-7 countries and a few other advanced and emerging economies, and from 1920 for additional advanced and emerging economies. 2 For low-income countries (LICs), data coverage generally starts in 1970.

14p yasuyidol 02-04-2013 50 3   Download

Film scholar and author Shoma Chatterji (Subject: Cinema, Object: Women, 1998) says, “Women in Hindi cinema have been decorative objects with rarely any sense of agency being imparted to them. Each phase of Hindi cinema had its own representation of women, but they were confined largely to the traditional, patriarchal frame-work of the Indian society. The ordinary woman has hardly been visible in Hindi cinema.” vi To understand this portrayal in much more depth, we need to have a look at some crucial glimpses which defined the role of women in Hindi films.

7p khanhchilam 01-04-2013 56 6   Download

Serving New Zealand’s future needs means we have to make sure that the education system performs well for Māori and that the needs of Māori children in education are met. This report describes the history of education policy and developments for Māori, sets out some leading research and statistics, and describes the role of the various government agencies involved in education. Under the Ministry of Education’s Ka Hikitia – Managing for Success strategy, there are many initiatives and programmes to lift Māori participation, engagement, and achievement.

0p tay_thi_le 19-02-2013 53 4   Download

'Accessible' means that not all the available resource can be used because of physical constraints (a large part of the aquifers, flood water greater than needed for reservoirs replenishment), inappropriate location or timeliness, inappropriate quality, and because part of the annual service flow has to be left to the ecosystem for its own needs.

40p bin_pham 06-02-2013 52 4   Download

The National Center for Education Statistics (NCES) is the primary federal entity for collecting, analyzing, and reporting data related to education in the United States and other nations.

67p bin_pham 05-02-2013 46 3   Download

‘Professions’ have been subject to a variety of theoretical schema that attempt to identify their unique characteristics or traits: the features that can be regarded as the basis for the discrimination between forms of occupational organization and control that are professional and those that are not (Saks, 1983; Abbott, 1988). This elaboration of the essential traits of professions is more than a professional discourse.

20p taisaovanchuavo 26-01-2013 43 7   Download

In the next section we outline some theoretical and empirical results about the relationships between monetary policy, the ináation target of monetary authorities, the level of this target perceived by the public and the long term interest rates dynamics. In section 3, we present the works of Kozicki and Tinsley (1998, 2001a, 2001b) and we establish the interest of this model in our framework.

38p taisaovanchuavo 23-01-2013 52 4   Download

The Semantic Web [22] holds out a different vision, that of information laid bare so that it can be collected, manipulated, and annotated independent of its location or presentation format- ting. While the Semantic Web promises much more effective access to information, it has faced a chicken-and-egg problem getting off the ground. Without substantial quantities of data avail- able in Semantic Web form, users cannot benefit from tools that work directly with information rather than pages, and Semantic Web-based software agents have little data to show their useful- ness.

18p machuavo 19-01-2013 47 4   Download

This paper borrows from the empirical literature on non-financial firms to explain the capital structure of large, publicly traded banks. It uncovers empirical regularities that are inconsistent with a first order effect of capital regulation on banks’ capital structure. Instead, the paper suggests that there are considerable similarities between banks’ and non-financial firms’ capital structures.

64p enterroi 02-02-2013 57 6   Download

Use of credit scores by insurers has come into prominence within the last ten years. A recent study found that more than 90 percent of personal lines insurers use credit scores for rating or underwriting private automobile insurance (Conning & Co., 2001), and many insurers also use credit scoring for homeowners coverage. Such scores are distinguished from credit scores used in financial underwriting.

69p enterroi 01-02-2013 47 2   Download

As discussed above in the context of the Asian financial crisis, capital controls and bank regulation in a particular country can dampen international credit flows or, depending on the type of regulation, they can favour one form of international credit over another. That is, international credit can flow both directly and indirectly, with the particular mix affected by policy and the organisation of globally active banks.

28p enter1cai 12-01-2013 46 2   Download