Gene cluster

This study aimed to identify metabolic subtypes in ESCA, explore their relationship with immune land‑ scapes, and establish a metabolic index for accurate prognosis assessment. Methods Clinical, SNP, and RNA-seq data were collected from 80 ESCA patients from the TCGA database and RNAseq data from the GSE19417 dataset. Metabolic genes associated with overall survival (OS) and progression-free survival (PFS) were selected, and k-means clustering was performed.

16p vikoch 27-06-2024 1 1   Download

Ebook "Hox genes: Studies from the 20th to the 21st century" was intended as a listing of the kinds of naturally occurring variation that could act as a substrate for the evolutionary process and Bateson took his examples from collections, both private and in museums, of materials displaying morphological oddities. Interestingly the person who also coined the term “Genetics” proffered little in the way of speculation on the possible genetic underpinnings of these oddities.

184p ladongphongthanh1008 22-04-2024 1 1   Download

Ebook "Copper and bacteria: Evolution, homeostasis and toxicity" summarizes the current knowledge of copper toxicity, homeostasis and resistance in bacteria, in which proteins like copper ATPases, copper chaperones and copper-responsive regulators of gene expression play major roles. The author also discusses the metallation of cuproenzymes. The evolution of the use of copper by cells and of copper-homeostatic proteins are is also considered in this brief.

99p tracanhphuonghoa1007 22-04-2024 2 2   Download

Mutations in the DMD gene encoding dystrophin—a critical structural element in muscle cells— cause Duchenne muscular dystrophy (DMD), which is the most common fatal genetic disease. Clustered regularly interspaced short palindromic repeat (CRISPR)-mediated gene editing is a promising strategy for permanently curing DMD.

19p vibransone 28-03-2024 5 2   Download

Ebook "HOX gene expression (Molecular biology intelligence unit)" is crucial not only in exploring the enigma of homeosis but also in understanding normal development at the fundamental molecular level. "Hox Gene Expression" starts with the amazing discovery of the homeobox twenty-three years ago and follows the exciting path thereafter of a series of breakthroughs in Genetics, Development and Evolution. It deals with homeotic genes- their evolution, structure, normal and abnormal function.

158p cotieubac1004 15-03-2024 1 0   Download

Genome-wide association studies (GWAS) of Alzheimer’s disease (AD) have identified several risk loci, but many remain unknown. Cerebrospinal fluid (CSF) biomarkers may aid in gene discovery and we previously demonstrated that six CSF biomarkers (β-amyloid, total/phosphorylated tau, NfL, YKL-40, and neurogranin) cluster into fve principal components (PC), each representing statistically independent biological processes.

23p vicwell 29-02-2024 5 2   Download

Many families and individuals do not meet criteria for a known hereditary cancer syndrome but display unusual clusters of cancers. These families may carry pathogenic variants in cancer predisposition genes and be at higher risk for developing cancer.

16p vicwell 29-02-2024 4 1   Download

Optimal integration of transcriptomics data and associated spatial information is essential towards fully exploiting spatial transcriptomics to dissect tissue heterogeneity and map out intercellular communications.

15p vicwell 29-02-2024 4 2   Download

Ebook "Horticultural nematology" has been written mainly with the objective of providing its readers, comprehensive information on the advanced aspects related to phytonematodes associated with horticultural crops. It also provides basic information on plant parasitic nematodes since it is required for a better understanding of advanced topics. Several popular topics, information on which is already available in plenty, have been avoided.

434p manmanthanhla0201 26-02-2024 5 1   Download

Ebook "Cellulose: Molecular and structural biology (Selected articles on the synthesis, structure, and applications of cellulose)" is an up-to-date treatise on the most advanced and provocative research into the biosynthesis, structure, and applications of Nature’s most abundant macromolecule and renewable resource, cellulose. Molecular, biochemical, and evolutionary aspects of cellulose biosynthesis are reviewed in a variety of living organisms, including cyanobacteria, eubacteria, vascular plants, and tunicates.

383p manmanthanhla0201 27-02-2024 3 2   Download

Single nucleotide polymorphisms (SNPs) located in microRNA (miRNA) binding sites can affect the interactions between miRNAs and target genes, which is related to cancer susceptibility and tumorigenesis. However, the association between SNPs located in miR-17-92 cluster binding sites and ESCC risk remains unclear.

12p vileonardodavinci 23-12-2023 3 3   Download

This study aimed to investigate the clinical utility of diverse aneuploid circulating tumor cell (CTC) subtypes and particularly CTC-associated white blood cell (CTC-WBC) clusters in predicting treatment response, prognosis and real-time monitoring disease progression in advanced driver gene-negative non-small lung cancer (NSCLC) patients.

12p visharma 20-10-2023 3 2   Download

Misidentification of the chicken leptin gene has hampered research of leptin signaling in this species for almost two decades. Recently, the genuine leptin gene with a GC-rich (~70%) repetitive-sequence content was identified in the chicken genome but without indicating its genomic position.

8p vinarcissa 21-03-2023 3 1   Download

Allotetraploid F1 hybrids (4nF1) (AABB, 4n = 148) were generated from the distant hybridization of Carassius auratus red var. (RCC) (AA, 2n = 100) (♀) × Megalobrama amblycephala (BSB) (BB, 2n = 48) (♂). It has been reported that Hox gene clusters are highly conserved among plants and vertebrates. In this study, we investigated the genomic organization of Hox gene clusters in the allotetraploid F1 hybrids and their parents to investigate the polyploidization process.

9p vinarcissa 21-03-2023 3 1   Download

Boar taint is principally caused by accumulation of androstenone and skatole in adipose tissues. Studies have shown high heritability estimates for androstenone whereas skatole production is mainly dependent on nutritional factors. Androstenone is a lipophilic steroid mainly metabolized in liver.

18p vinarcissa 21-03-2023 2 1   Download

Mussels of the genus Mytilus present morphologically similar karyotypes that are presumably conserved. The absence of chromosome painting probes in bivalves makes difficult verifying this hypothesis. In this context, we comparatively mapped ribosomal RNA and histone gene families on the chromosomes of Mytilus edulis, M. galloprovincialis, M. trossulus and M. californianus by fluorescent in situ hybridization (FISH).

11p vinarcissa 21-03-2023 3 1   Download

In genetic analysis of agronomic traits, quantitative trait loci (QTLs) that control the same phenotype are often closely linked. Furthermore, many QTLs are localized in specific genomic regions (QTL clusters) that include naturally occurring allelic variations in different genes

17p vinarcissa 21-03-2023 3 1   Download

In this study, 23 GASA genes in common bean were identified and detailed bioinformatics analyzes were conducted at both gene and protein levels. Pvul-GASA proteins were categorized into three clusters, and a total of 13 duplication events (12 segmental and one tandem) were shown to play a role in the expansion of the GASA gene family in Phaseolus vulgaris L. The identified Pvul-GASAs have been shown to be linked to stress and hormone signaling pathways.

36p lyhuyenthu 31-01-2023 4 2   Download

The association between autophagy and immunity, including infiltrating immunocytes, immune reaction gene-sets, and HLAs (human leukocyte antigen) gene, remains unclear. The present study aimed to provide a valid diagnostic tool for coronary artery disease (CAD), and explore the pathological mechanisms of CAD based on the association between autophagy and immunity.

14p vihagrid 30-01-2023 6 3   Download

Identifying co-expressed gene clusters can provide evidence for genetic or physical interactions. Thus, co-expression clustering is a routine step in large-scale analyses of gene expression data. We show that commonly used clustering methods produce results that substantially disagree and that do not match the biological expectations of coexpressed gene clusters.

11p vigalileogalilei 27-02-2022 8 1   Download