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Gene pool
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While effective vaccines are being administered globally, there is still a great need for antiviral therapies as antigenically novel SARS-CoV-2 variants continue to emerge across the globe. Viruses require host factors at every step in their life cycle, representing a rich pool of candidate targets for antiviral drug design.
18p
viellison
28-03-2024
1
1
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Part 1 book "Multi-objective optimization in chemical engineering" includes content: Introduction, optimization of pooling problems for two objectives using the ε-Constraint method, multi objective optimization applications in chemical engineering, performance comparison of jumping gene adaptations of the elitist non dominated sorting genetic algorithm, improved constraint handling technique for multi objective optimization with application to two fermentation processes,... and other contents.
256p
muasambanhan09
12-03-2024
7
0
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Part 1 book "Managing breeds for a secure future - Strategies for breeders and breed associations" includes content: Introduction, breeds, basics of breeds, defining an individual breed, breeds as genetic pools - variability and predictability, animal identification, maintaining breeds, strategies for population management, gene flow into and out of breeds, specific breeding plans.
177p
oursky09
08-11-2023
6
2
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This research aimed to investigate the roles of fanconi anemia complementation group D2 (FANCD2) on the regulation of ferroptosis in osteosarcoma progression. The function of FANCD2 on cell viability, invasion, migration, and tumor growth were explored. FANCD2 and pathway-related genes were determined by western blot. Ferroptosis-associated markers were determined, including lipid peroxidation, labile iron pool (LIP), ferrous iron (Fe2+), and ferroptosis-related genes.
11p
vischultz
20-10-2023
4
1
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The tertiary gene pool of bread wheat, to which Leymus racemosus belongs, has remained underutilized due to the current limited genomic resources of the species that constitute it. Continuous enrichment of public databases with useful information regarding these species is, therefore, needed to provide insights on their genome structures and aid successful utilization of their genes to develop improved wheat cultivars for effective management of environmental stresses.
17p
vinarcissa
21-03-2023
5
1
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Studies on nanoparticle-protein interaction have also not been studied. This would give information on ratio influence on the structural alteration of EGCg in EGCg-AuNPs and its functionality in vivo. Herein, the optimisation of EGCg-AuNPs will be determined with a large pool of stoichiometric synthesises of gold and EGCg. These optimised EGCg-AuNPs would then be studied with bovine serum albumin (BSA) for protein interactions, binding and thermodynamics.
177p
runthenight07
01-03-2023
5
2
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"Evaluation of Lonicera caerulea L. genotypes based on morphological characteristics of fruits germplasm collection" is known that a polymorphic population consisting of a large number of genotypes adapts more rapidly to the environment conditions. The availability of a large gene pool predetermines the success of the introduction and further breeding of new cultivars with economically valuable features. Morphometrics is a classical tool for studying the amplitude of the variability of cultivated plants and evaluating the genotypic diversity of the artificial population.
13p
lyhuyenthu
31-01-2023
7
2
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Experimental studies indicate that neuroendocrine pathways might play a role in progression of breast cancer. We aim to test the hypothesis that somatic mutations in the genes of neuroendocrine pathways influence breast cancer prognosis, through dysregulated gene expression in tumor tissue.
10p
visusanwojcicki
28-06-2022
8
2
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The genetic origins of Uralic speakers from across a vast territory in the temperate zone of North Eurasia have remained elusive. Previous studies have shown contrasting proportions of Eastern and Western Eurasian ancestry in their mitochondrial and Y chromosomal gene pools.
20p
vigalileogalilei
27-02-2022
13
1
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The long introns of mammals are pools of evolutionary potential due to the multiplicity of sequences that permit the acquisition of novel exons. However, the permissibility of genes to this type of acquisition and its influence on the evolution of cell regulation is poorly understood.
13p
vigalileogalilei
27-02-2022
10
1
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Genome-wide loss-of-function screens using the CRISPR/Cas9 system allow the efficient discovery of cancer cell vulnerabilities. While several studies have focused on correcting for DNA cleavage toxicity biases associated with copy number alterations, the effects of sgRNAs co-targeting multiple genomic loci in CRISPR screens have not been discussed.
25p
vigalileogalilei
27-02-2022
16
1
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Little is known about the peopling of the Sahara during the Holocene climatic optimum, when the desert was replaced by a fertile environment. Results: In order to investigate the role of the last Green Sahara in the peopling of Africa, we deep-sequence the whole non-repetitive portion of the Y chromosome in 104 males selected as representative of haplogroups which are currently found to the north and to the south of the Sahara.
15p
vialfrednobel
29-01-2022
11
0
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Aggregating transcriptomics data across hospitals can increase sensitivity and robustness of differential expression analyses, yielding deeper clinical insights. As data exchange is often restricted by privacy legislation, meta-analyses are frequently employed to pool local results.
26p
viarchimedes
26-01-2022
11
0
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The spatiotemporal control of 3D genome is fundamental for gene regulation, yet it remains challenging to profile high-resolution chromatin structure at cis-regulatory elements (CREs). Using C-terminally biotinylated dCas9, endogenous biotin ligases, and pooled sgRNAs, we describe the dCas9-based CAPTURE method for multiplexed analysis of locus-specific chromatin interactions.
20p
viarchimedes
26-01-2022
14
0
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Improved methods are needed to model CRISPR screen data for interrogation of genetic elements that alter reporter gene expression readout. We create MAUDE (Mean Alterations Using Discrete Expression) for quantifying the impact of guide RNAs on a target gene’s expression in a pooled, sorting-based expression screen. MAUDE quantifies guide-level effects by modeling the distribution of cells across sorting expression bins.
16p
viarchimedes
26-01-2022
17
0
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The Asian chestnut gall wasp (ACGW), Dryocosmus kuriphilus, native to China was accidentally introduced into many countries worldwide, including Italy. Different susceptibilities have been reported in literature among cultivated plants belonging to different gene pools worldwide, but this aspect has not been sufficiently explored among wild chestnut populations. The aims of this multiyear study were (i) to assess differences in susceptibility to ACGW in wild C.
11p
dolomite36
30-12-2021
8
0
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As CRISPR/Cas9 mediated screens with pooled guide libraries in somatic cells become increasingly established, an unmet need for rapid and accurate companion informatics tools has emerged. We have developed a lightweight and efficient software to easily manipulate large raw next generation sequencing datasets derived from such screens into informative relational context with graphical support.
13p
vilarryellison
29-10-2021
2
1
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Expression screening of environmental DNA (eDNA) libraries is a popular approach for the identification and characterization of novel microbial enzymes with promising biotechnological properties. In such “functional metagenomics” experiments, inserts, selected on the basis of activity assays, are sequenced with high throughput sequencing technologies. Assembly is followed by gene prediction, annotation and identification of candidate genes that are subsequently evaluated for biotechnological applications.
10p
vilarryellison
29-10-2021
9
1
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While pooled loss- and gain-of-function CRISPR screening approaches have become increasingly popular to systematically investigate mammalian gene function, the large majority of them have thus far not investigated the influence of cellular heterogeneity on screen results.
9p
vigiselle2711
30-08-2021
7
1
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Phylogenetic analyses of the bacterial genomes based on the simple classification in core- genes and accessory genes pools could offer an incomplete view of the evolutionary processes, of which some are still unresolved.
15p
viansan2711
30-07-2021
10
1
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