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Gene retention
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Alternative splicing, particularly through intron retention and exon skipping, is a major layer of pre-translational regulation in eukaryotes. While intron retention is believed to be the most prevalent mode across non-animal eukaryotes, animals have unusually high rates of exon skipping. However, when and how this high prevalence of exon skipping evolved is unknown.
21p
vigalileogalilei
27-02-2022
10
1
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The sharp increase of plant genome and transcriptome data provide valuable resources to investigate evolutionary consequences of gene duplication in a range of taxa, and unravel common principles underlying duplicate gene retention.
23p
vigalileogalilei
27-02-2022
11
1
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While intron retention (IR) is now widely accepted as an important mechanism of mammalian gene expression control, it remains the least studied form of alternative splicing. To delineate conserved features of IR, we performed an exhaustive phylogenetic analysis in a highly purified and functionally defined cell type comprising neutrophilic granulocytes from five vertebrate species spanning 430 million years of evolution.
15p
vialfrednobel
29-01-2022
2
0
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Intron retention (IR) occurs when an intron is transcribed into pre-mRNA and remains in the final mRNA. We have developed a program and database called IRFinder to accurately detect IR from mRNA sequencing data. Analysis of 2573 samples showed that IR occurs in all tissues analyzed, affects over 80% of all coding genes and is associated with cell differentiation and the cell cycle.
11p
vialfrednobel
29-01-2022
8
0
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Alternative splicing (AS) is a widespread regulatory mechanism in multicellular organisms. Numerous transcriptomic and single-gene studies in plants have investigated AS in response to specific conditions, especially environmental stress, unveiling substantial amounts of intron retention that modulate gene expression.
26p
viarchimedes
26-01-2022
10
0
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Millennia of directional human selection has reshaped the genomic architecture of cultivated cotton relative to wild counterparts, but we have limited understanding of the selective retention and fractionation of genomic components.
26p
viarchimedes
26-01-2022
10
0
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RNA splicing is a key post-transcriptional mechanism that generates protein diversity and contributes to the fine-tuning of gene expression, which may facilitate adaptation to environmental challenges. Here, we employ a systems approach to study alternative splicing changes upon enteric infection in females from classical Drosophila melanogaster strains as well as 38 inbred lines.
19p
viarchimedes
26-01-2022
5
0
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Peanut is the world’s fourth largest oilseed crop that exhibits wide cultivar variations in cadmium (Cd) accumulation. To establish the mechanisms of Cd distribution and accumulation in peanut plants, eight cDNA libraries from the roots of two contrasting cultivars, Fenghua 1 (low-Cd cultivar) and Silihong (high-Cd cultivar), were constructed and sequenced by RNA-sequencing.
16p
viseulgi2711
31-08-2021
6
1
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Mutations in minor spliceosome components such as U12 snRNA (cerebellar ataxia) and U4atac snRNA (microcephalic osteodysplastic primordial dwarfism type 1 (MOPD1)) result in tissue-specific symptoms.
19p
visilicon2711
20-08-2021
15
1
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Despite the growing interest in the female side of copulatory interactions, the roles played by differential expression and alternative splicing mechanisms of pre-RNA on tissues outside of the reproductive tract have remained largely unknown.
13p
vilichoo2711
23-06-2021
7
1
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In eukaryotes, most genes code for multiple transcript isoforms that are generated through the complex and tightly regulated process of RNA splicing. Despite arising from identical precursor transcripts, alternatively spliced RNAs can have dramatically different functions.
7p
vijisoo2711
27-10-2020
12
1
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Plants have evolved disease resistance (R) genes encoding for nucleotide-binding site (NB) and leucine-rich repeat (LRR) proteins with N-terminals represented by either Toll/Interleukin-1 receptor (TIR) or coiled-coil (CC) domains.
11p
viminato2711
22-05-2020
15
1
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Recurrent gene duplication and retention played an important role in angiosperm genome evolution. It has been hypothesized that these processes contribute significantly to plant adaptation but so far this hypothesis has not been tested at the genome scale.
15p
viminato2711
22-05-2020
5
0
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Due to the climate change of the past few decades, some agricultural areas in the world are now experiencing new climatic extremes. For soybean, high temperatures and drought stress can potentially lead to the “green seed problem”, which is characterized by chlorophyll retention in mature seeds and is associated with lower oil and seed quality, thus negatively impacting the production of soybean seeds.
15p
vihashirama2711
21-05-2020
18
0
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Rice is one of the world’s most important crops. Thus, it is necessary to improve it by genetic transformation. IR64 is a highyielding and disease-resistant variety, but it is sensitive to abiotic stresses, mainly salinity and drought.
10p
vikimsa
22-02-2019
16
1
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The cellular retinoic acid-binding protein type I (CRABPI) is encoded by a single gene in mammals. We have characterized twocrabp1genes in zebra-fish, designatedcrabp1a and crabp1b. These twocrabp1 genes share the same gene structure as the mammalianCRABP1genes and encode proteins that show the highest amino acid sequence identity to mammalian CRAB-PIs. The zebrafishcrabp1aandcrabp1bwere assigned to linkage groups 25 and 7, respectively.
11p
fptmusic
11-04-2013
30
1
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Fatty acid-binding protein type 1 (FABP1), commonly termed liver-type fatty acid-binding protein (L-FABP), is encoded by a single gene in mam-mals. We cloned and sequenced cDNAs for two distinct FABP1s in zebra-fish coded by genes designatedfabp1a andfabp1b. The zebrafish proteins, FABP1a and FABP1b, show highest sequence identity and similarity to the human protein FABP1.
14p
inspiron33
25-03-2013
38
2
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Familial hypercholesterolemia is an autosomal dominant disease caused by mutations in the gene encoding the low-density lipoprotein receptor. To date, more than 900 different mutations have been described. Transport-defective mutations (class 2) causing partial or complete retention of the receptor in the endoplasmic reticulum are the predominant class of muta-tions.
13p
galaxyss3
19-03-2013
28
2
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The final report will contain an introduction or overview of the organisation followed by an account of the units or areas visited by the inspection team and a description of practices which normally will refer to relevant data protection principles such as ‘fair processing’/‘fair obtaining’ or data retention. The final section of the report will contain an overall conclusion, set of findings and a series of recommendations. The inspection team will aim to achieve agreement with the audited entity regarding the text of the final report, but this is not always possible.
135p
tay_thi_le
19-02-2013
78
12
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Complete plastid genome sequences suggest strong selection for retention of photosynthetic genes in the parasitic plant genus Cuscuta
22p
panasonic06
26-12-2011
50
4
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