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Genetic factors contributes
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The genetic and immunological factors that contribute to differences in susceptibility and progression between sub-types of inflammatory and autoimmune diseases continue to be elucidated. Inflammatory bowel disease and juvenile idiopathic arthritis are both clinically heterogeneous and known to be due in part to abnormal regulation of gene activity in diverse immune cell types.
16p
vibransone
28-03-2024
2
2
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Congenital heart disease (CHD) occurs in almost 1% of newborn children and is considered a multifactorial disorder. CHD may segregate in families due to significant contribution of genetic factors in the disease etiology. The aim of the study was to identify pathophysiological mechanisms in families segregating CHD.
13p
vibransone
28-03-2024
4
2
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Alterations in genetic and epigenetic landscapes are known to contribute to the development of different types of cancer. However, the mechanistic links between transcription factors and the epigenome which coordinate the deregulation of gene networks during cell transformation are largely unknown.
16p
vioraclene
31-03-2024
2
2
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Endometrial cancer studies have led to a number of well-defined but mechanistically unconnected genetic and environmental risk factors. One of the emerging modulators between environmental triggers and genetic expression is the microbiome. We set out to inquire about the composition of the uterine microbiome and its putative role in endometrial cancer.
15p
vioraclene
31-03-2024
2
1
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Ebook "Genetics and human behaviour: The ethical context" provides readers with contents including: Chapter 1 - Introduction; Chapter 2 - The historical context; Chapter 3 - Research in behavioural genetics; Chapter 4 - Quantitative genetics: measuring heritability; Chapter 5 - Identifying genetic factors contributing to individual differences in behaviour; Chapter 6 - Research in behaviour genetics involving animals;...
258p
manmanthanhla0201
26-02-2024
4
1
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The relative contributions of genetic and environmental factors versus unavoidable stochastic risk factors to the variation in cancer risk among tissues have become a widely-discussed topic. Some claim that the stochastic effects of DNA replication are mainly responsible, others believe that cancer risk is heavily affected by environmental and hereditary factors.
12p
vileonardodavinci
23-12-2023
4
4
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Part 1 book "Genetics and the behavior of domestic animals" includes content: Behavioral genetics and animal science; behavioral genetics and animal domestication; how studying interactions between animal emotions, cognition, and personality can contribute to improve farm animal welfare; genetics and behavior during handling, restraint, and herding; reproductive and maternal behavior of livestock; factors influencing the expression of behavior in the domestic dog.
275p
oursky09
12-11-2023
10
3
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Genetic and lifestyle factors both contribute to the pathogenesis of bladder cancer, but the extent to which the increased genetic risk can be mitigated by adhering to a healthy lifestyle remains unclear. We aimed to investigate the association of combined lifestyle factors with bladder cancer risk within genetic risk groups.
11p
visharma
20-10-2023
5
2
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Infertility is a global concern that affects 15% of couples, and roughly half of those cases are male-specific. Among the genetic factors that contributed heavily to male infertility, TEX15 (testisexpressed gene 15) has been studied across multiple cohorts worldwide and identified to relate to meiotic recombination failure and DNA repair system malfunction.
6p
vimulcahy
18-09-2023
8
3
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Genetic ancestry is a critical co-factor to study phenotype-genotype associations using cohorts of human subjects. Most publicly available molecular datasets are, however, missing this information or only share self-reported race and ethnicity, representing a limitation to identify and repurpose datasets to investigate the contribution of ancestry to diseases and traits.
5p
visteverogers
24-06-2023
3
2
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Coronary artery calcified atherosclerotic plaque (CAC) predicts cardiovascular disease (CVD). Despite exposure to more severe conventional CVD risk factors, African Americans (AAs) are less likely to develop CAC, and when they do, have markedly lower levels than European Americans. Genetic factors likely contribute to the observed ethnic differences.
13p
vinarcissa
21-03-2023
3
1
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Genetic factors play an important role in hearing loss, contributing to approximately 60 % of cases of congenital hearing loss. Autosomal dominant deafness accounts for approximately 20 % of cases of hereditary hearing loss. Diseases with autosomal dominant inheritance often show pleiotropy, different degrees of penetrance, and variable expressivity.
11p
vinarcissa
21-03-2023
4
1
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Nonsyndromic orofacial clefts are one of the most common birth defects worldwide. It occurs as a result of genetic or environmental factors. This study investigates the genetic contribution to nonsyndromic cleft lip and/or palate through the analysis of family pedigrees.
9p
vinarcissa
21-03-2023
1
1
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Congenital hearing loss (CHL) is diagnosed in 1 – 2 newborns in 1000, genetic factors contribute to two thirds of CHL cases in industrialised countries. Mutations of the GJB2 gene located in the DFNB1 locus (13q11-12) are a major cause of CHL worldwide.
12p
vinarcissa
21-03-2023
4
1
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Down syndrome incidence in humans increases dramatically with maternal age. This is mainly the result of increased meiotic errors, but factors such as differences in abortion rate may play a role as well. Since the meiotic error rate increases almost exponentially after a certain age, its contribution to the overall incidence aneuploidy may mask the contribution of other processes.
8p
vinarcissa
21-03-2023
5
1
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The incidence of differentiated thyroid carcinoma (DTC) in Cuba is low and the contribution of host genetic factors to DTC in this population has not been investigated so far. Our goal was to assess the role of known risk polymorphisms in DTC cases living in Havana.
9p
vinarcissa
21-03-2023
2
1
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Despite the success of genome-wide association studies (GWAS), there still remains “missing heritability” for many traits. One contributing factor may be the result of examining one marker at a time as opposed to a group of markers that are biologically meaningful in aggregate.
9p
vinarcissa
21-03-2023
2
1
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Patellar luxation is an orthopedic disorder in which the patella moves out of its normal location within the femoral trochlea of the knee and it can lead to osteoarthritis, lameness, and pain. In dogs it is a heritable trait, with both environmental and genetic factors contributing to the phenotype.
9p
vinarcissa
21-03-2023
3
1
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Complex genetic factors underlie testicular germ cell tumor (TGCT) development. One experimental approach to dissect the genetics of TGCT predisposition is to use chromosome substitution strains, such as the 129.
12p
vinarcissa
21-03-2023
2
1
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DNA methylation plays a key role in development, contributes to genome stability, and may also respond to external factors supporting adaptation and evolution. To connect different types of stimuli with particular biological processes, identifying genome regions with altered 5-methylcytosine distribution at a genome-wide scale is important.
9p
vinarcissa
21-03-2023
4
1
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